Interesting new study of pramipexole in anhedonic low mood in mdd, bipolar and dysthymia. Some cool mechanistic outcomes: www.researchsquare.com/article/rs-7...

Really interesting, brief ideas paper. Clearly relevant to treatment research-- the mechanism by which you leave an illness state is unlikely to just be the opposite of the mechanism by which you entered it (can see how this might apply to e.g. SSRIs in depression).

Gulliver Waite took part in the PAX-D trial testing Pramipexole for treatment resistant depression @ox.ac.uk. He told @theguardian.com how being part of the study made a difference to his life. 👉 Gulliver's story www.theguardian.com/society/2025... 👉 The findings www.psych.ox.ac.uk/news/parkins...

Really lovely story from one of our participants in the recent PAX-D study. If you are interested in the results of the study, you can find them here: www.thelancet.com/journals/lan...

‘I wish I took part sooner’: how a medical trial transformed a young person’s life

Curious about how scientists measure brain activity through EEG? Swipe to read more! ⚡️

Depression can affect the mind, body and daily life in ways you might not expect. 🧠Swipe to learn the key signs and symptoms – and why recognising them matters. #Depression #Mentalhealth #Research

New preprint alert with @mikebrowning.bsky.social and Chamith Halahakoon! People have been using computer-based reinforcement learning tasks with affect probes. But to what extent do they reflect real-life affective experience? We tested this with 3 weeks of EMA + RL tasks in 339 participants.

Pramipexole vs. quetiapine vs. amantadine in TRD. Interesting open label, short term RCT using a surprisingly low dose (I suspect that the reported dose of 37.5mg of pramipexole is a typo and it should be 0.375mg) www.sciencedirect.com/science/arti...

V important meta-analysis doi.org/10.1001/jama...: Discontinuation symptoms 1 week post stopping antidepressants was below the threshold for clinically significant discontinuation syndrome. Later worse mood is likely depression relapse @jfhayes.bsky.social @sameerjauhar.bsky.social.

🎊Recently, colleagues from across the @NIHRresearch Mental Health Translational Research Collaboration (MH-TRC) gathered for a celebration of progress and partnership in mental health research. ➡️ oxfordhealthbrc.nihr.ac.uk/nihr-mental-...

Our new study published in TheLancetPsych! We found that pramipexole augmentation substantially reduced depressive symptoms in patients with treatment-resistant depression over 48 weeks of treatment. This is an important advance in how we treat depression! 1/6 www.thelancet.com/journals/lan...

Delighted to announce this position www.northlondonmentalhealth.nhs.uk/current-vaca.... It's part of the Mental Health Mission Mood Disorders Research Clinic Network, aiming to support clinical trials in mood disorders in the UK. Should be very interesting! oxfordhealthbrc.nihr.ac.uk/mhm/mood-dis...

RELMED.ac.uk is now open to recruitment. This @wellcometrust.bsky.social-funded study wellcome.org/research-fun... will ask whether reinforcement learning tasks are differentially sensitive to dopaminergic and serotonergic antidepressants.