Excited to share our Version of Record in eLife! We find that two ways of inhibiting a brainstem structure (PPN) actually result in completely different and even opposite behaviors. One inhibitory connection is rewarding and one is aversive.

I have a first serious attempt to estimate the consequences of multi-year funding for July. For new R01s, the amount of additional expenditure was $135 M The number of additional R01s that could have been funded is 182 1/9

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

"It’s like taking over a hospital and making the surgeons break bones instead of fix them, like suddenly requiring your engineering firm to use 'three' in place of pi, like telling a three-star chef her new goal is to make all the patrons puke."

My quote of the day A Video Quote Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble. (From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)

Happy 107th Birthday, Brenda Milner! Her contributions to neuropsychology shaped the way we understand the human brain. From surviving two world wars and two pandemics, to paving the way for future generations of researchers, Milner’s legacy continues. @mcgill.ca @cusm-muhc.bsky.social

We were honored to attend the 2025 Parkinson’s Disease Gordon Conference in Waterville Valley, NH. It was wonderful to bring together some of the best and brightest scientists to discuss the most exciting developments in PD research, including many of our own awardees and SAB members!

This is worse than many appreciate because it is not merely a delay. Many institutions such as mine are TERMINATING these otherwise active grants if the NoA is delayed by more than a month because they cannot afford to keep the grant supported personnel on payroll

NYT, Page One: “Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.” @nytimes.com

Senate hearing on the FY26 NIH budget with Jay Bhattacharya June 10, 10am ET www.appropriations.senate.gov/hearings/a-r...

If you burn down a forest, you don't miss out on lumber for just that season. You have to replant all the trees, nurture them, and wait for them to grow. The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.

Trump’s cuts to research programs directly harms scientists from working class backgrounds. Bridges built between the blue collar and ivory tower are collapsing in front of us.

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

Am I crazy or did we just have a convo about how we can't fund cancer research?

REMINDER.....REMINDER......REMINDER 3 DAYS LEFT TO COMMENT ON SCHEDULE F 1/n

That’s a plan to reclassify tens of thousands of government jobs as “policymaking positions” and therefore subject to presidential appointment and removal of those who occupy these positions. 2/n

Donald Trump cut funding for cancer research by 31% in the first three months of his term. This is an attack on every American family who has loved someone with cancer.

"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants. Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

As we point out in Science, the Trump proposal to convert NIH program officer jobs into political appointments (Schedule F) will mean, that instead of actual scientific experts, people like "Big Balls" will choose how to direct NIH funds. www.science.org/doi/10.1126/...

From the @sltrib.com, @bagleycartoons.bsky.social

Today it was seeing a major microscope manufacturer say they had the hardest day of their 35+ year career because they had to lay off a ton of staff due to not enough orders coming in because of all the science grants being rescinded in the U.S. 🧪🦠

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

“However bad everyone on the outside thinks it is, it is a million times worse. They’re dismantling and destroying everything.” Read, share, respond. Call your representatives. The health and well-being of Americans & America's innovation economy are at stake. www.science.org/content/arti...

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

My first author paper is officially out!! Thank you to all of my co-authors for their help & support. So proud of the final product 😄😄

The dismantling of the NIH continues (gift article) wapo.st/44uaqzG

Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu

1/ Why do patients with late-stage cancer lose motivation & sink into apathy? 🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵 🔗 doi.org/10.1126/scie...

Tariffs get all the attention, but ask economists what they're really worried about and many will point to the Trump administration's cuts to federal support for the sciences, including canceling grants and revoking student visas. #EconSky www.nytimes.com/2025/03/31/b...

FACULTY JOB ALERT! The Albert Einstein Dept of Neuroscience is hiring a new assistant professor in any area of neuroscience! We have funds specifically earmarked for this search. #Neuroscience #AcademicJobs #NeuroSky Job just posted: faculty-einstein.icims.com/jobs/17175/f... Please share widely!!

14 pages of terminated NIH grants--everyone should read through the list. The sweep is VERY broad, including "The Impact of the Herpes Zoster Vaccine on Herpes Zoster Ophthalmicus" & "Mitochondrial-based Determinants of Sex Differences in Acute Kidney Injury"🧪 1/n taggs.hhs.gov/Content/Data...

We have multiple openings for basic addiction scientists interested in pursuing translational research within the Kahlert Institute for Addiction Medicine @kahlertumsom.bsky.social apply @ umb.taleo.net/careersectio... and learn about our institute @ addiction.umaryland.edu

I don't see enough people or reporters talking about the mass terminations of nih lgbtq+ grants that happened yesterday. How can we get the word out so communities understand the huge loss to science, safety, and economy this is?? #academicsky

🚨I converted the list of terminated #NIH grants (as of 3/22) into a google sheet. I added activity codes and award jurisdictions (see tabs for grant count and $ by each). Note this HHS list likely does not include all planned/completed terminations as of this date.🚨 Please use, share and distribute!

🧵Yesterday, I received notice that my #NIH grant, on the social environment, lifecourse, epigenetics & #birthoutcomes in Black families, was terminated. This grant represented a critical effort to address the ⬆️ rates of maternal & infant mortality in the US, particularly among Black mothers & babies

"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...

Amidst all that is crumbling around us, I am really proud of my group for pressing on and disseminating our science. I'm happy to share that this work led by @tdowns.bsky.social is now in press and open access! www.sciencedirect.com/science/arti...

as I tell my Genetics class every year, this breakthrough is based on 70 years of NIH-funded, basic research, commercialized by biotech bsky.app/profile/need...

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

I’m back to this again. Based on ~1 hour of data munging using the list of 76 unpublished NOFOs posted last week (both current and former opp. #s), this accounts for grants in every US state (except WY), Puerto Rico, Guam, and the US Virgin Islands.

Another week passes with nothing posted in the NIH Guide. grants.nih.gov/grants/guide...

I recently spoke at a Congressional briefing with a military veteran from our PTSD clinical trial on the life-changing impact of the NIH Brain Initiative. Watch here👇 braininitiative.nih.gov/news-events/... The BRAIN Initiative is now facing a 20% cut on top of the 40% last yr…

From the other site... (from EVP at Columbia to a training grant director)

This message needs to be heard widely.

One penny per tax dollar is what science, ALL science in America costs. I would gladly spend two or even three cents per tax dollar to double or triple what America spends on science. That is how you make things better, for everyone.

UAB Neurobiology is hiring up to 4 new tenure-track faculty as part of 3 new open-rank searches. Come join our vibrant, supportive, and growing neuroscience community! uab.peopleadmin.com/postings/23916 uab.peopleadmin.com/postings/23944 uab.peopleadmin.com/postings/24010

Last year, I was overjoyed to receive an NIH NRSA fellowship to study toddler brains and caregiving effects on memory at Columbia. Last night, my grant was terminated.

Useful information for those new to mice. See Jax Labs for more excellent information on all things mouse.