Filipe Carvalho (@ffchcarvalho.bsky.social)

This paper advances deep proteome sequencing, improving detection of protein variants & isoforms beyond standard shotgun proteomics. By analyzing six human cell lines, it identifies a million unique peptides from 17,717 protein groups, highlighting translation of most alternatively spliced isoforms.

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Global detection of human variants and isoforms by deep proteome sequencing - Nature Biotechnology Deep proteome sequencing achieves ~80% coverage of the human proteome. https://doi.org/10.1038/s41587-023-01714-x