Alexandre Jorge Pinto
@alexjpinto.bsky.social
π€ 128
π₯ 125
π 2
Research Fellow @ i3S | Tuberculosis Research
reposted by
Alexandre Jorge Pinto
Tiago Beites
19 days ago
Mycobacterium tuberculosis is an outlier in many ways. One of them is keeping a high degree of functional redundancy despite its obligate pathogen lifestyle. In this review, we reflect on the biological meaning of M. tuberculosis functional redundancies.
journals.plos.org/plospathogen...
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Essential redundancies fuel Mycobacterium tuberculosis adaptation to the host
Redundancy in biology is, at a glance, counterintuitive because if the function of two gene products completely overlaps then, throughout the course of evolution, one of the genes will likely accumula...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013749
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reposted by
Alexandre Jorge Pinto
Tiago Beites
19 days ago
Excellent teamwork with my talented PhD students
@marcopsilva.bsky.social
and
@alexjpinto.bsky.social
Also happy because this is the first outcome 100%
@i3suporto.bsky.social
made. Hopefully, the first of many more to come.
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I'm excited to share my first, first-author paper!
add a skeleton here at some point
8 months ago
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reposted by
Alexandre Jorge Pinto
bioRxiv Microbiology
9 months ago
The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection
https://www.biorxiv.org/content/10.1101/2025.04.14.648703v1
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reposted by
Alexandre Jorge Pinto
Tiago Beites
11 months ago
What a great conference
#EMBOtuberculosis
has been! Amazing science, amazing food and a very friendly community! And it was a pleasure to share the work weβre developing at i3S U. Porto.
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Excited to share the work I have been a part of and also my first paper, regarding how different strains of Mycobacterium tuberculosis induce IL-1B production and inflamassome activation
academic.oup.com/jid/advance-...
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Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1Ξ² secretion independently of macrophage metabolic rewiring
The glycolytic pathway is required for maximum IL-1Ξ² production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae583/7906538?utm_source=advanceaccess&utm_campaign=jid&utm_medium=email&nbd=39370074470&nbd_source=campaigner
about 1 year ago
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reposted by
Alexandre Jorge Pinto
Tiago Beites
about 1 year ago
Introducing my wonderful team at i3S - University of Porto. PhD student
@marcopsilva.bsky.social
and research fellow
@alexjpinto.bsky.social
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