3️⃣ Noninferiority of One HPV Vaccine Dose to Two Doses nej.md/49OEzg1 𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲: A single shot of HPV vaccine may be enough to fight cervical cancer, study finds (AP) nej.md/4jnT0KC

Three must-read articles that made news in December: 1️⃣ Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL 𝗡𝗼𝘁𝗮𝗯𝗹𝗲 𝗵𝗲𝗮𝗱𝗹𝗶𝗻𝗲: Pioneering new treatment reverses incurable blood cancer in some patients (BBC) nej.md/497Tgdp

Researchers led by Dr. Jessica Stark (@jcstark.bsky.social) have developed a new way to stimulate the immune system to attack tumor cells, using a strategy that could make #CancerImmunotherapy work for many more patients. 📰 MIT News: https://bit.ly/3YlpCeq

Available to read now via #OpenAccess pubs.rsc.org/en/content/a... @ki.se @petterbrodin.bsky.social

Hi fellow membrane protein #StructuralBiology people! Do you use maltoside detergents / model them in your stuctures? Watch out! ⚠️ Most PDB models of LMNG and GDN are wrong ❌, yet continue to be re-used. Spread the word! See more: doi.org/10.1021/acsc... (w. @sebvidalchem.bsky.social ) #cryoEM

PCAs (paws of cats across snow)

We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org

Review | From bulk RNA sequencing to spatial transcriptomics: a comparative review of differential gene expression analysis methods link.springer.com/article/10.1...

In an update of the BArT study, direct-acting antivirals led to durable responses in HCV-associated indolent B-cell lymphomas, with 6-year progression-free survival of 66% and no relapses after a complete response. Read the full update: nej.md/48OP2qS #MedSky #Hematology #GastroSky

Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble. In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,

What method should you use to track migrating cells? Read "Methods to analyze cell migration data: fundamentals and practical guidelines" to find the best cell tracking tool. Download the paper here: www.nature.com/articles/s41...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

After resistance to epidermal growth factor receptor tyrosine kinase inhibitors develops in EGFR-mutated lung cancer, treatment options are limited. Findings on sacituzumab tirumotecan, an antibody–drug conjugate targeting Trop-2, are summarized in a new Quick Take video. nej.md/49b6oNC

Dysregulated activation responses is a defining feature of HSPC aging and establish proliferative stress–based xenotransplantation is a powerful platform for investigating age-related hematopoietic dysfunctions @jem.org @dimiccolab.bsky.social rupress.org/jem/article-...

Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma www.nature.com/articles/s41... 🧪 #PancreaticCancer

My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵

The best science images of 2025, as picked by Nature, include the Sun’s fiery surface, a tattooed tardigrade, and rare red lightning. See more. 🧪

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

A thorough review of deep-learning approaches (I prefer that to "AI") for enhancing super-resolution microscopy by @orangeroad2017.bsky.social, Yang Zhang and colleagues in @natmethods.nature.com: doi.org/10.1038/s415...

Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation. The findings published in Nature Medicine in January suggest that SARS-CoV-2 may increase the risk of future Alzheimer’s disease. #Medsky 🧪

Blood Test Identifies Colon Cancer in Adults Ages 20-35 With 98.5% Accuracy Study: An Exosome-Based Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer: The ENCODER Multicenter Study buff.ly/xi4fYNY #medsky #GIsky 🛟🧪

Conserved Neuronal-like and Secretory Programs Define the Spatial Architecture of Gastroenteropancreatic Neuroendocrine Tumors https://www.biorxiv.org/content/10.64898/2025.12.28.696762v1

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in #PancreaticCancer 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...

There’s still time to apply to our PhD program in Neuroscience at MUSC - app window closes 1/15/26 - tinyurl.com/mtnskh6e

The editors of Cancer Today share the most impactful stories in cancer care in 2025, from funding cuts in research to advances in targeting pancreatic cancer.

🌍 This is one of the projects I’m most proud of since returning to Manchester 🇬🇧 🤝 🇺🇦. Huge thanks to Rachel, Harry, Jenny, Su, Prof Aziz, Prof Choudhury, Prof Cowan & many other #TeamManchester 🐝 colleagues at The Christie for making this happen. More to come - watch the space!

For patients with MRSA or VRE, would you continue the use of contact precautions in the hospital or discontinue them? Read the case vignette, options, and vote: nej.md/3MAfb49 #MedSky #MedEd

Structure, Function and Dynamics of mCoral, a pH-Responsive Engineered Variant of the mCherry Fluorescent Protein with Improved Hydrogen Peroxide Tolerance www.mdpi.com/1422-0067/27...

We’re always adding new articles to The Cancer Researcher online magazine, from inspiring updates from our funding recipients to our Highlights in Cancer Research round-ups. If you’ve got a quiet moment over the festive break, why not catch up and browse the latest pieces? ☕ magazine.eacr.org

Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD #gdTcells @natcomms.nature.com

Aging increases ovarian cancer growth, metastasis and immunosuppression that can be alleviated by inhibiting hedgehog signaling https://www.biorxiv.org/content/10.64898/2025.12.23.695206v1

#VascularMalformation Tie2+ Endothelial Cell Tie2 L914F transgenic🐭▶️ Early defects in vascular development (E9.5) 👉Yolk Sac 👉Pharyngeal Arch Arteries/Aortae 👉Cranial Vessels 👉Intersomitic Vessels 👉E13.5 Death @boscololab.bsky.social #DevDyn 2025 anatomypubs.onlinelibrary.wiley.com/doi/full/10....

A 43-year-old woman who had a cervical ectopic pregnancy diagnosed at a Florida clinic at 10 weeks’ gestation was denied care at two hospitals owing to the presence of a detectable fetal heart rate. Full case details: nej.md/3KWXjQm

Science for the win👇🏻👇🏻👇🏻🎉🎉

SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in #PancreaticCancer www.nature.com/articles/s12... 🧪

Merry Christmas from all of us at The University of Manchester! 🌟 We hope you're all having a wonderful winter break. Thanks to our Instagram follower oe_perspective for the photo.

Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in #PancreaticCancer cells www.nature.com/articles/s41... 🧪

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL https://www.biorxiv.org/content/10.64898/2025.12.21.694897v1

New #JobOffers with the #SBNBLab - Join us in #Barcelona! 🚀 Our multidisciplinary, international team at @irbbarcelona.org is hiring experts to help us push the boundaries of #systemspharmacology and contribute to research that impacts human #health. 🧬💻💊 Details below:

Looking for your next career move in science? We are #hiring! Discover our latest job and #PhD opportunities! #Jobs ➡️ https://bit.ly/irbjobs PhD General call ➡️ https://bit.ly/3LtzIXi PhD IRB DRIVE call ➡️ https://bit.ly/4hODx5B #IRBJobs #ScienceJobs #JobOffer #JobOffers #OncoSky #AcademicSky 🧪

Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy https://www.biorxiv.org/content/10.64898/2025.12.19.695209v1

This crazy world got you feeling down? Just listen to a little perspective from Monty Python’s Meaning of Life: #MontyPython #meaningoflife

Human monocytes placed on a soft matrix undergo phase separation into micro domains. On glass/plastic, monocytes do not form such domains. See more details in our recent paper in Nature Materials: www.nature.com/articles/s41...

A metabolic atlas of mouse aging: Cell Metabolism www.cell.com/cell-metabol...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. www.science.org/doi/10.1126/...

Our call for 27 PULSE #postdocs is OPEN! PhD within the last 3 years looking to grow your life science career? SciLifeLab PULSE (MSCA Cofund) offers 3-year postdoc fellowships at Swedish universities with academic & industry secondments 🧪 🖥️ 🧬 📅 Apply Dec 15, 2025-Mar 16, 2026 👉 bit.ly/3MD7Pwz

Hurrah! Should never have left though. www.theguardian.com/world/2025/d...