We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

If you ever wondered about the history and current state of plant Clathrin-mediated endocytosis....here is a review just for you! onlinelibrary.wiley.com/doi/10.1111/... Was really fun to write this with awesome co-authors! ⚽️🌱🔬

In todays epidode of 'whats in the comically large thermo box?' - a comically small 250 uL secondary. 🤦‍♀️

Oh my. This is spectacular. sinceyouarrived.world/taken

There is still time to register for @focalplane.bsky.social's inaugural plant imaging webinar tomorrow. #plantimaging focalplane.biologists.com/2026/03/30/n...

It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one! Make sure to come to our other talk today on using this tech to study endosomal dynamics?

Going to #DynamicCellVI ? Be sure to pop by the poster flash talks and poster session on Wednesday to learn how to make any dual-camera microscope multispectral ! If you pop by the poster you can see a cool 3D printed model of the system!

#BlackInNeuro, #BlackInSTEM? Heads up that this fantastic postdoc opportunity opens for applications this month (closing date 17th May). Come and join us at @mrclmb.ac.uk! mrclmb.ac.uk/careers-and-...

Presented our work on developing novel image splitters to enable dual camera simultaneous multispectral imaging with no compromise in spatiotemporal resolution, and the development of modular fluorescent microspheres at #FOM2026 ! Here for longer if anyone wants a chat!

The last time I attended #FOM, I was presenting my PhD work on human tonsils - this time round, I'll be presenting fun quest in the postdoc journey where we (w/ @jamesdmanton.bsky.social and the LMBs mechanical workshop) designed and validated a novel 4-way image splitter! #FOM2026 Mon 30th @ 4:30

So useful!

GitHub will be allowing Copilot to use your code for training its models, unless you opt out. Seems like the sort of thing some people might want to opt out of…

Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/... #Cytoskeleton

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

#membrane seminars are back this week wirh Manu @deriverylab.bsky.social and Andela Šarić! Join us on Thursday at 5 pm CET spread the word!

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @ycharos.bsky.social : zenodo.org/records/1162...

🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨

To complement the launch of our new LMB website, we’ve shared a new introductory video on our YouTube channel. Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works. youtu.be/JmC17_4bEMA?...

Following coverage over the weekend of Sir Paul Nurse's comments that suggested that the only reason that a Fellow should be expelled from @royalsociety.org is scientific misconduct, I have written to him to explain the risks such an attitude poses of increasing sexual harassment in STEM.

Now published with peer-review-induced improvements in Biomedical Optics Express: doi.org/10.1364/BOE.579043 We continue to recommend the use of Sarstedt lumox dishes for ease of use and high-quality imaging performance: bsky.app/profile/jame...

For an internal talk, I wanted an easy way to disprove the prevailing myth that expansion microscopy gels expand due to repulsion between charged polymer strands. I did a quick calculation of the supposed energy released during a standard experiment and it's equivalent to a small nuclear bomb...

If you run across a gen A.I. slop 🤖💩 diagram in an academic journal, I’d love to know about it! Please fill out this form: docs.google.com/forms/d/e/1F... Slop in journals is illuminating about journals’ quality control. And journals would like you to forget their mistakes. #AcademicChatter

There’s just ONE WEEK left to apply to join our amazing PhD programme next year! Visit our website for more information: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd DEC 2025

Considering the LMB for your PhD? We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int... Apply by 2nd DEC for Autumn 2026 admission.

Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science www.nature.com/articles/d41...

We are delighted to announce the Strathclyde Optical Microscopy Course 2026 (SOMC26), taking place in Glasgow from 21st July – 30th July 2026! Please find more details at shorturl.at/xmUiZ and apply at shorturl.at/MxTlI. Deadline 16 January 2026.

Missed the 2025 Next Generation Biophysics Symposium? Great news – you can now watch the fantastic talks on our YouTube channel! www.youtube.com/playlist?lis... Don't miss these great discussions on how new and emerging technologies may be able to address challenging biological questions.

📣 We are hiring! An education-focused Lecturer or Senior Lecturer in Quantitative Biomedical or Biophysical sciences. It’s a chance to be a part of a team of single molecule /cellular biophysicists building a brand new undergraduate curriculum, here at UNSW in sunny Sydney. Happy to answer queries.

PhD project available in my lab. Email me with CV if interested www.findaphd.com/phds/project... #microsky #bioimaging

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Oh how sad Really a towering figure, whose work laid the ground for stem cells, regenerative biology etc I go to know him well over many years and he was definitely one-of a-kind...

Considering a PhD in molecular biology? Make sure to check out the projects on offer at the LMB! www2.mrc-lmb.cam.ac.uk/students/int... General applications by 2nd DEC. US Gates Scholarship applications by 15th OCT. #PhD

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

Bluesky, meet Goose! Pudge is a big sister and she is not happy about it!

Early-career researchers, apply for a funded place at our Macro to Micro: Quantitative Plant Imaging Across Scales Workshop. Find out more: www.biologists.com/workshops/fe... #Workshop #Plants #Cells #Imaging #Microscopy #Microscope #Research #PlantPhysiology #PlantCells

Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions? Don’t mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September! Find out more details and register here: www3.mrc-lmb.cam.ac.uk/sites/nextgen/

Pudge is thrilled about her new pal, Hamma-cat-su, picked up at #MMC2025 ! @hamamatsucorp.bsky.social

It was an absolute pleasure to speak at #MMC2025 this week! The first time talking about my postdoc work from the past year or so! Thanks to everyone for their interest in LIVE multispectral TIRF imaging! Great to hang out with my old lab too!

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info: www.nature.com/naturecareer... Apply by 10 JUL #ScienceJobs

Please share with anyone who has experience in protein expression / purification and cloning - no PhD needed! We are super friendly and don't bite :D LMB is a cracking place to work and Cambridge is lovely 😍

Frozen cat tubes going down well in this heat 🫠 🔥 🐈

I may be biased, but I think Pudge might just be the prettiest cat 🥰

Interested in imaging plants, then this is a great workshop for you! We have a great line up of speakers from plant and ‘outside’ fields, fantastic location and spaces for ECRs to come and join in the fun! 🌱🔬💻🤓

Absolutely thrilled to have won a poster prize when presenting my post doc work for the first time! Had a fantastic day thus far at the #MicrotubuleMeeting !

Come chat to me at the #MicrotubuleMeeting to learn about our multispectral imaging applications!

We present: A deconvolution solution to aliasing confusion in apparently undersampled oblique plane microscopy doi.org/10.1101/2025... [1/8]

Thanks to some CUDA trickery*, our automatic parameter-free deconvolution code is now ~3× faster than the previous version (~9× faster than the original) while still producing exactly the same results as before. Try it out for free using Google Colab at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/ 1 / 2

In our latest interview, we hear from the 2024 @bscb-official.bsky.social Hooke Medal winner Emmanuel Derivery @deriverylab.bsky.social. Emmanuel tells us about his research, what winning the Hooke Medal means to him & his advice on building a successful lab. journals.biologists.com/jcs/article/...

A busy weekend for us packing ahead of a house move (local!) next week. Project manager Pudge is feeling extra tired!