Our group has been looking at beta bursts for the last 5 years, but we do it a little differently than most - we group into types them based on their waveforms. In this open access article we lay out why and what we think this might mean journals.sagepub.com/doi/10.1177/... #neuroskyence

#fluorescencefriday microglia (yellow) and Abeta plaques (magenta) in our AD mouse model in 3D from a cleared 🧠 using @lifecanvastech.bsky.social SHIELD Courtesy of @shahrzadbahrampour.bsky.social and @nadiahaghbinphd.bsky.social with @mind-western.bsky.social and @neuroak.bsky.social Low-res.

Absolutely amazing chart from @peterkellner.bsky.social's piece in @thenewworldmag.bsky.social today: www.thenewworld.co.uk/peter-kellne...

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model https://www.biorxiv.org/content/10.1101/2025.11.25.690488v1

An issue we're seeing at all levels of university is that many students are simply refusing to do *anything*. They aren't reading the syllabus, aren't following assignment guidelines, aren't engaging with material, ignoring deadlines. And this might seem like old news, but it truly has ramped up.

Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)

Great Review on the #evolution of #microglia Microglia across evolution: from conserved origins to functional divergence | Cellular www.nature.com/articles/s41...

Constanze Depp is finding that microglia aren't any better at multitasking than we are—and that likely contributes to the development of Alzheimer's. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪 🧠

PRESS RELEASE! Building on the pioneering work of Dr. Alison Goate, an int'l team, led by @mountsinainyc.bsky.social's Anne Schaefer, ID'd a distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers 👉 www.mountsinai.org/about/newsro...

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2) forum.image.sc/t/bigvolumeb...

Chatgpt uses em-dashes quite often & people started using the presence of em-dashes to raise concern that something (ex: homework) was written by ai. So the only reason anyone would instruct chatgpt to not use em-dashes is to hide the fact that the work was chatgpt generated. Groundbreaking ethics!

Last-minute advert for the Convpaint workshop at I2K by Roman Schwob! Interactive segmentation in @napari.org. Today 2:00 PM CET. Free registration: www.i2kconference.org/workshops

I’m super excited to share that my PhD work is now out in npj Imaging (@natureportfolio.nature.com)! 🔬 You can read the paper here: rdcu.be/eOKdU

First ever public presentation of single cell evidence for non-spatial grid cells by Elena Gutierrez, Seb Veselic from Steve Kennerley lab. Steve an I have been dreaming of this moment for nearly 10 years. #sfn25

LLMs get a lot of attention but if you are interested in the original (allegedly) stochastic parrots come to my poster Tuesday where I will present new work on the natural vocal behavior or parrots and its cortical control #Sfn2025 #SfN25

MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony. Or from a single dish of HEK cell culture in the case of two membrane proteins. Out in Nature Methods now! lnkd.in/gpyBSceg Wonderful collaboration with the Efremov lab.

I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...

Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)

Mycophenolate mofetil reduces the branching of microglial processes https://www.biorxiv.org/content/10.1101/2025.11.12.687812v1

Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS

Diving into the literature… I think it's the first time I see correlative live-cell/EM data after photobleaching - it shows how intense light can actually destroy microtubules rather than just bleach fluorescent tubulin along a neurite (from onlinelibrary.wiley.com/doi/10.1002/...)

Nightmare #423: -- 1,140 sq ft spider web -- populated by a metropolis of 111,000 spiders -- in a cave 😱 www.nytimes.com/2025/11/08/s...

Look out for this later #histSTM (And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)

This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.

Using #LLMs for science👨‍💻💬? We have a fun tool for you: introducing #folder2md4llms. It converts an entire folder of docs/code/pdfs/pptx into a single markdown file that you can upload to your chatbot of choice. We use it to talk with our publications database or code repos github.com/HenriquesLab...

💥 DeepInverse is now part of the official PyTorch Landscape💥 We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc. pytorch.org/blog/deepinv...

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

www.thetransmitter.org/computationa... 'Such a map could form the basis for a model in which every input-output function that can measured will act as a piece of the simulation'. Wonderful essay about 'completing' a C. Elegans model, by Boyden and Körding

I always get drawn back to Al Gore telling voters that he’d only raise taxes on the top 1% and then after the election a poll showed that something like 20% of voters thought they were in the top 1% and another 20% thought they would be in the next five years. Just a total tragic disconnect.

Microglia are the brain’s most dynamic cells, constantly extending and retracting their processes to monitor the parenchyma and respond to potential danger with inflammatory signaling. Our new study in @ScienceAdvances @science.org explores how these functions are regulated.

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

That's a hell of a figure. www.alzforum.org/news/researc...

🚨Preprint: Semantic Tuning of Single Neurons in the Human Medial Temporal Lobe 1/8: How do human neurons encode meaning? In this work, led by Katharina Karkowski, we recorded hundreds of human MTL neurons to study semantic coding in the human brain: doi.org/10.1101/2025...

What a time to be alive

You might have noticed lots of activity in the napari project recently! 🚀 We're grateful for a grant from CZI that's keeping us going, but grants don't last forever: we're trying to figure out sustainable long term funding. Read our blog post to find out how you can help: napari.org/island-dispa...

this entire week has been one single PSA: "the cloud" just means "someone else's computer" and that "someone else" is one of three companies and they don't give a s**t about you

𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻?? Astrocytes in the regulation of fear memories! www.nature.com/articles/s41... #neuroskyence h/t @claeneuro.bsky.social

Hi. I wrote an essay about AI slop: How it feels like an invasive species for the internet. How its boosters describe building a future that’s devoid of craft. How frictionlessness can be nihilistic & how this stuff seems to leach part of our shared humanity out of the world. I hope you'll read it.

Why do rustbelts vote radical right? Studying the German Ruhr area, @nilsblossey.bsky.social, @lstoetze.bsky.social and I show: it’s not just about deindustrialization, but also about the original industrialization. Where coal is buried deeper and mining started later, the AfD is stronger today 1/12

Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵

Excited to share our work making an "allostasis-first" case that brain function is most productively framed in terms of its core regulatory function. We also introduce some new ideas in the context of metabolism and cognitive function in Alzheimer's. www.cell.com/neuron/fullt...

PREACH! www.nature.com/articles/s41...

I'm thrilled to share that our work studying microglia morphological changes in early Alzheimer's in mice is up! www.biorxiv.org/content/10.1...

Our next book: "Making the Modern Laboratory" An illustrated, coffee table-sized volume, it covers the origins of the machines, organisms and tools used in modern biology research. More importantly, it's a call to imagine the FUTURE of the laboratory. Come help us write it!

I cannot understand what these people think the purpose of human life is? It is *not* "pursue joy, deal justly, love well, try to understand as much and see as much of this beautiful world and of the deepness, richness and variety of human culture and experience as you can before you die"?

"From cells to pixels: A decision tree for designing bioimage analysis pipelines" by Elnaz Fazeli, Robert Haase, Michael Doube, Kota Miura & David Legland is free-to-view here: doi.org/10.1111/jmi....