kevinbolding.bsky.social
@kevinbolding.bsky.social
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Memory / olfaction PI at Monell Chemical Senses Center in Philly boldinglab.org
[email protected]
Anyone know where to find an example of an inhibitory cross-correlogram produced by a somatostatin interneuron?
#neuroskyence
4 months ago
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youtu.be/JZIv0KV71S4?...
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김정미 - 추억 (1973 초판), Kim Jung Mi, Memories
YouTube video by 집고양이
https://youtu.be/JZIv0KV71S4?si=lxWq8JEasZ0KL3kS
8 months ago
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Matteo Carandini
9 months ago
Neuropixels and Optogenetics are delighted to announce the birth of Neuropixels Opto Combining high-resolution electrophysiology and optogenetics Today in bioRxiv 960 sites, 28 emitters, 2 colors By Lakunina,
@karolinazsocha.bsky.social
, Ladd, et al
www.biorxiv.org/content/10.1...
(1/2)
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Tim Kietzmann
9 months ago
This year we ran another meme contest as part of my ML4CCN lecture series. Student submissions were fantastic. Guess the paper...
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10 months ago
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's
@ivychanchiwai.bsky.social
findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
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Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body
Neural representations of sensory stimuli serve multiple distinct purposes, from the rapid recognition of familiar environments, to the precise identification of individual salient cues. In the insect...
https://www.biorxiv.org/content/10.1101/2025.01.25.634657v1
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@dlp.
9 months ago
John Cohen, Painter/Collage Artist/Graphic Designer Robert Rauschenberg Preparing for a Show at the Tanager Gallery, 10th St, New York City, 1959.
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Jonathan Lambert
9 months ago
NSF’s cash management service is now back up and running. Seems like they responded to the court order.
new.nsf.gov/executive-or...
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NSF Implementation of Recent Executive Orders
Information for the NSF community regarding executive orders.
https://new.nsf.gov/executive-orders
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Christopher Dornan
9 months ago
Here's the speech if you haven't heard it. 13 minutes of your time. Share it with your American friends and neighbours, because they won't see it otherwise. Circulate it in Mexico and Denmark, France and the UK, Panama and Germany, Poland and Estonia, and especially -- especially -- Ukraine.
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Trudeau: Canada will retaliate with 25% tariffs on $155B of U.S. goods
YouTube video by CBC News
https://youtu.be/xiaACQpFUfE?si=8yhugUS0KGNH10GC
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Daniel Gonzales
9 months ago
Really proud to see my postdoc work out!! We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
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Touch-evoked traveling waves establish a translaminar spacetime code
Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.
https://www.science.org/doi/10.1126/sciadv.adr4038
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Caitlin Mallory
9 months ago
1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in
@science.org
, along with a wonderful preview by Daniel Bendor!
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The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
https://www.science.org/doi/10.1126/science.ads4760?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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Julian Meeks
9 months ago
Someone needs to be reaching out to these philanthropies to make it VERY CLEAR that the return on investment from their donations will TANK with NIH and NSF being affected, and that THEIR GOOD MONEY and investment is being being WASTED by these inexcusable (from a business angle) actions.
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Julian Meeks
9 months ago
Sources of philanthropic giving to biomedical science and training programs (graduate and medical school programs, etc.) are NOT going to backstop the loss of NIH, NSF Funding. They aren't able to do so, and many of them may not want attention. BUT they have sway, and have money in the game.
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Karl Herrup
9 months ago
My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on
#Alzheimer's
disease (
nam12.safelinks.protection.outlook.com?url=https%3A...
)
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Opinion | The Devastating Legacy of Lies in Alzheimer’s Science
Fraud in research needs to end.
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nytimes.com%2F2025%2F01%2F24%2Fopinion%2Falzheimers-fraud-cure.html&data=05%7C02%7Cherrup%40pitt.edu%7Ca573a04665024895adcd08dd3e5cf3b4%7C9ef9f489e0a04eeb87cc3a526112fd0d%7C1%7C0%7C638735291138685604%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=chiQj18IBsi0brREJ1KdhReq%2BeHhXvxdyaIufWY%2BT5Q%3D&reserved=0
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Alice Ting
9 months ago
Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for neuroscience,
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Kindra Crick 🧩
9 months ago
Capturing the detail of this monoprint as the writing reveals itself when viewed at an angle. Writing is from a 1953 letter from my grandad, Francis Crick, to his 12 year old son detailing in simple terms how DNA was a code and how it might copy itself.
#sciart
#dna
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Adrien Peyrache
9 months ago
🚨Important paper alert (a bit late, but see below) Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.
www.cell.com/cell-reports...
Another story to tell about this paper 👇 1/5
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Latent learning drives sleep-dependent plasticity in distinct CA1 subpopulations
Guo et al. find that when mice repeatedly explore a novel environment, a distinct subset of neurons in the CA1 region of the hippocampus, which initially exhibits weak spatial selectivity, gradually d...
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01379-2
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Dinu F Albeanu
10 months ago
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills!
tenss.ro
Apply by: February 16th!
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Bob Pellegrino
10 months ago
Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here. From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."
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The Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of Food
People with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...
https://link.springer.com/chapter/10.1007/978-3-031-41375-9_8
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The reveal of what she created here (the strings, the screamed chorus) had me crying laughing. Truly bonkers.
youtu.be/DwhbnN9hCtI
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I Made Good Luck Babe By Chappell Roan Without Hearing It
YouTube video by Dev Limes
https://youtu.be/DwhbnN9hCtI
10 months ago
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Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
10 months ago
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Dayu Lin
10 months ago
Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.
www.nature.com/articles/s41...
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Experience-dependent dopamine modulation of male aggression - Nature
Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.
https://www.nature.com/articles/s41586-024-08459-w
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Dinu F Albeanu
10 months ago
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...
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Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal - Nature Communications
Hernandez-Trejo, Ciuparu, and Garcia da Silva et al. report that the piriform-to-olfactory bulb feedback in the mouse carries multimodal identity and reward contingency signals, which are re-formatted...
https://doi.org/10.1038/s41467-025-56023-5
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Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence
10 months ago
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Gord Fishell
10 months ago
Alison's work is always worth a look! SST interneurons provide precise inputs to the various dendritic branches of pyramidal cells, as well as providing strong interneuron regulation. Go take a look at this review of their role in cognition and learning!
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Eliezyer de Oliveira
10 months ago
Question for people going from intan based ephys to neuropixels. Do you have an alternative for the accelerometer from the intan headstage? That was a nice feature that is missing on freely moving neuropixels recordings 🧠📈
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10 months ago
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Sarthak Chandra
10 months ago
1/ Super-excited to share our new work “Episodic and associative memory from spatial scaffolds in the hippocampus”, that just appeared in Nature!
www.nature.com/articles/s41...
Key insights and ideas 👇#tweeprint
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Episodic and associative memory from spatial scaffolds in the hippocampus - Nature
A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.
https://www.nature.com/articles/s41586-024-08392-y
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Brad Hulse
10 months ago
Jeff Taube joined Jim ~2 yrs later and, together with Bob Muller, the trio quantitatively characterized HD cells’ tuning curves for the first time (using a 2-spot video tracker!). In 1990, they published their classic papers in the journal of neuroscience.. (2/3)
www.jneurosci.org/content/10/2...
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Brad Hulse
10 months ago
Happy head direction cell day y’all! On this day, 41 years ago, Jim Ranck recorded the first “HD cell” in his Brooklyn lab in 1984. Jim shared the news with the world at SFN that year, showing a video of the cell’s firing on a TV he somehow acquired and brought to his poster… (1/3)
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Andres Bendesky
10 months ago
Nice feature in The Scientist on the power of using 𝘗𝘦𝘳𝘰𝘮𝘺𝘴𝘤𝘶𝘴 mice to study evolution of social and other behaviors. Beautiful lead photo of an Oldfield dad with his pups by Wyatt Toure in my lab.
www.the-scientist.com/on-a-wild-mo...
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On a Wild Mouse Chase to Understand Parenting, Love, and Fear
Studying a diverse and peculiar genus of mice offers researchers a window into the genetic and neural underpinnings of behavior.
https://www.the-scientist.com/on-a-wild-mouse-chase-to-understand-parenting-love-and-fear-72447
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Leslie M Kay, PhD
10 months ago
It's out! Awesome study by
@kruthikamaheshwar.bsky.social
. We found that female rats sample for shorter times in odor habituation. Gamma and beta oscillations in the olfactory bulb are lower amplitude for females, but only during odor sampling.
#ChemSenses
#neuroskyence
🧪
doi.org/10.1152/jn.0...
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Sex differences in olfactory behavior and neurophysiology in Long Evans rats | Journal of Neurophysiology
In many species, olfactory abilities in females are more acute than those in males. Studies in humans show that women have lower olfactory thresholds and are better able to discriminate and identify odors than men. In mice, odorants elicit faster activation from a larger number of olfactory bulb glomeruli in females than in males. Our study explores sex differences in olfaction in Long Evans rats from a behavioral and electrophysiological perspective. Local field potentials (LFPs) in the olfactory bulb (OB) represent the coordinated activity of bulbar neurons. Olfactory gamma (65–120 Hz) and beta (15–30 Hz) oscillations have been functionally linked to odor perception. Spontaneous and odor-evoked OB LFPs were recorded from awake rats at the same time for 12 days. Odors used included urine of both sexes and monomolecular odorants characterized previously for correlation of volatility with behavior and OB oscillations. Sampling duration in a habituation context, baseline gamma and beta power, and odor-elicited beta and gamma power were analyzed. We find that females sample odorants for a shorter duration than males (just over 1-s difference). Although baseline gamma and beta power do not show significant differences between the two sexes, odor-elicited gamma and beta power in females is significantly lower than in males. Neither sampling duration nor beta and gamma power in females varied systematically with day of estrus. We further verify that variance of these behavioral and physiological measures is not different across sexes, adding to growing evidence that researchers need not be concerned about often-claimed additional variance in female subjects. NEW & NOTEWORTHY Olfaction plays a large role in evolutionary processes. However, we know little about sex differences in olfactory bulb neurophysiology, and many scientists believe that females are more variable because of estrus. We show that female rats sniff odors for shorter durations than males and have lower power in neural oscillations related to cognition. Estrus was not related to variance in any measures. Finally, males and females show equal variance on these behavioral and physiological processes.
https://doi.org/10.1152/jn.00222.2024
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Kara Marshall
10 months ago
An important article describing the challenges of treating pain, and the terrible frustration and suffering from living with it.
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We set out to do a typical thing in the ephys lit: use troughs in CCGs as complementary evidence of inhibitory cell type… but we see big oscillatory energy in many of them. Anyone else been down this road?
#neuroskyence
@ihstevenson.bsky.social
@dlevenstein.bsky.social
Any examples in papers?
10 months ago
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Izumi Fukunaga
10 months ago
Really enjoying the inspiring talks from the Brain Prize webinar series: Neural Circuits of the Mind: Frontiers of Computational Neuroscience. Highly recommended!
lundbeckfonden.com/brain-prize-...
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Brain Prize Webinar Series 2024:
Neural Circuits of the Mind: Frontiers of Computational Neuroscience
https://lundbeckfonden.com/brain-prize-webinar-series-2024
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Janelia Research Campus
10 months ago
🔬 The Shroff Lab & collaborators have developed a new AI method that produces sharp microscopy images throughout a thick biological sample without using adaptive optics, adding additional hardware, or taking more images. 🔗
https://hhmi.news/3DLUEF8
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Dan Goodman
10 months ago
Friedemann Zenke has joined Bluesky
@fzenke.bsky.social
. This gives me an opportunity to repost my spiking neurons and neuromorphic starter pack. I've been quietly adding names to it, but I'm sure there are people I've missed so let me know to add you/someone else! 🤖🧠🧪
go.bsky.app/46Eu9GG
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Andrea Hoerr
10 months ago
This seemed to have excellent points about land aconowledgements. As a non-Native, I defer to the wisdom of those who are before deciding whether to share on other platforms with less fruitful dialog. 🪶Gift article.
www.nytimes.com/2025/01/05/o...
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Opinion | Enough With the Land Acknowledgments (Gift Article)
Instead of proclaiming performative acknowledgments of Native peoples, institutions should establish strong relationships with Native nations.
https://www.nytimes.com/2025/01/05/opinion/indigenous-people-land-acknowledgments.html?unlocked_article_code=1.m04.vP4H.XYNGNeA0rHo4&smid=nytcore-ios-share&referringSource=articleShare&tgrp=ctr
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⚡️GREG_CORDER⚡️
10 months ago
1/ 🧠 Excited to share our new preprint: Convergent state-control of endogenous opioid analgesia We uncover how cognitive + contextual factors—like injury, fear, and placebo—modulate pain through dynamic opioid signaling in the periaqueductal gray (PAG)
biorxiv.org/content/10.1...
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Annegret Falkner
10 months ago
We track changes in this network across many days and show that experience and observation recruit overlapping subcortical networks (a whole “mirroring” network) and result in a similar “relaxation” of aggression inhibitory control. Super cool findings! Major kudos to Jorge Iravedra Garcia!
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Annegret Falkner
10 months ago
New year new work from the lab! We explore whether aggression experience and observation lead to similar changes in future aggression strategy. (They do!) We perform 2-color imaging across the whole social behavior network across time and track changes
www.biorxiv.org/content/10.1...
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Aggression experience and observation promote shared behavioral and neural changes
The ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition. A foundational question is whether social o...
https://www.biorxiv.org/content/10.1101/2024.12.26.630396v1
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Hongyu_Chang
10 months ago
SEEING THROUGH YOUR EYES 👁️: Excited to share our new paper (which is out now
@nature.com
!!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay!
#Neuroscience
#hippocampus
nature.com/articles/s41...
🧵 1/12👇
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Sleep microstructure organizes memory replay - Nature
The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.
https://nature.com/articles/s41586-024-08340-w
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eLife
11 months ago
Authors of this paper on ageing and senescence massively improved their paper after just one revision, with evidence jumping from “incomplete” to “compelling”. You can openly view reviews and version histories alongside the final paper.
#12DaysOfeLife
https://buff.ly/4fTdI2A
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Zach Peterson
11 months ago
The Neighborhood Listen is as funny as it gets (imo, anyways) and I think it’s among the best of
@pftompkins.bsky.social
work, of which there is a lot. The season finales w/ Mitch Silpa absolutely slap. The chemistry among PFT, Nicole, and Brett is incredible, and this season has been truly demented
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Any Single Places with Mitch Silpa
Podcast Episode · The Neighborhood Listen · 12/24/2024 · 1h 26m
https://podcasts.apple.com/us/podcast/the-neighborhood-listen/id1517151870?i=1000681516899
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Talmo Pereira
11 months ago
In case you haven't seen it yet, movement is one of the most interesting and well engineered toolkits working with pose tracking data like from
sleap.ai
! Strong recommend 🤙
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Takaki Komiyama
11 months ago
Is there a known mechanism that silences and unsilences LTP?
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Franck Polleux
11 months ago
Delighted to highlight our new paper in
@natureportfolio.bsky.social
entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇):
www.nature.com/articles/s41...
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Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
https://www.nature.com/articles/s41586-024-08325-9
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Johnston Lab
11 months ago
We have a fresh new paper! The PhD project of the talented Mark Conway. A learning-induced change in the sensitivity of olfactory receptor neurons enables consistent perception of an odor.
#olfaction
#neuroscience
www.science.org/doi/10.1126/...
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Perceptual constancy for an odor is acquired through changes in primary sensory neurons
Learning-induced changes in primary sensory neurons support concentration-invariant perception of an odor.
https://www.science.org/doi/10.1126/sciadv.ado9205
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