Mychael Lourenco (@mvlourenco.bsky.social)

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enzymes are exocytosed. The PI3K-AKT pathway modulates this process. Microglia also exocytose intralysosomal undigested fibrillar Aβ toward extracellular aggregates, potentially contributing to plaque growth. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01403-7?rss=yes&utm_source=dlvr.it&utm_medium=twitter