“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

Please keep in mind: 2 cups per day ☕️☕️

Preprint alert!!📑 We're happy to share a new preprint from our associated member, Dr Maximilian Reuter (@reuterlm.bsky.social), on "Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution"  🔎Read more here: www.biorxiv.org/content/10.6...

Do you work in DNA replication, genome maintenance, chromosome organisation, chromatin maintenance, or a related field? 🧬 Join us for #EESReplication – submissions are welcome from researchers at all career stages! 20 – 23 October 2026 Send your abstract by 28 July: s.embl.org/ees26-13-bl

New preprint🎉 Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated. 👉 doi.org/10.64898/202...

📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch. #PhDStudentship #LifeSciences #DNAReplication #CRISPR

Our speaker - Prof. Helle Ulrich - invites fresh perspectives on DNA repair & genome stability. 🧬 Continue the conversation at our conference "The Evil Within: Regulation and Repair of Endogenous DNA Damage." (IMB Mainz, 10–13 Mar 2026). Register → www.sfb1361.de/dnarepairconf2026

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin

We have an open call for a group leader at the Rudolf Virchow Center for Integrative and Translational Bioimaging in Würzburg, Germany. Generous starting package, vibrant and highly interdisciplinary biomedical research environment. www.nature.com/naturecareer... Please spread the word.

💡 PhD student position at the University of Birmingham, UK. Fully funded by MRC AIM doctoral training programme. 4 years. Open to 🇬🇧 🇪🇺 & 🌎. DNA replication 🧬 . Collaboration with Prof Andrew Wilson (Chemistry). Deadline midday (GMT) 9 January 2026. Please share 😀👍 www.findaphd.com/phds/project...

🚨Post open in our lab! Come work on some cool themes involving metabolism, chromatin, early development 🤓. Pls RT

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT). Informal enquiries to [email protected] APPLICATION LINK: sits.bham.ac.uk/urd/sits.urd...

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

@mpercharde.bsky.social & I after presenting our experience of setting up the @mrc-lms.bsky.social Roving Researcher scheme to support Postdocs on leave, in the Research Culture session at #MRCBiomedicine2025 Look at that view! Blooming love London

📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project. This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes 📅 Closes on 10 Dec. www.jic.ac.uk/vacancies/36...

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing! docs.google.com/spreadsheets...

📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social www.findaphd.com/phds/project... 📅 January 7, 2026 Please RP🙏thx!

Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?

Registration is open! Join us at IMB Mainz from 10–13 March 2026 for the 2nd International IMB & SFB 1361 Conference on "The Evil Within: Regulation and Repair of Endogenous DNA Damage". Don't miss this conference and register now via www.sfb1361.de/dnarepairconf2026 #ISC26DNArepair #IMBMainz

We are launching 11 new #PhD opportunities today! If you would like to contribute to the research at the LMS apply today! #medicalscience #lifescience

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

We are deeply saddened to announce the unexpected passing of our colleague Dr Nard Kubben. He joined IMB as a Group Leader in 2021, bringing a passion for understanding ageing & improving human health. Our heartfelt condolences go to his family, friends & all who knew him. www.imb.de/about-imb/ne...

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Our IPP Community! 🫶 The past 2 days, we gathered at the annual IPP Symposium to connect with students from @unimainz.bsky.social, Uni Med #Mainz and IMB, share ideas, and get inspired by each other's research. Apply to our open call via www.imb.de/phd and be a part of next year's event.

Yesterday’s full-day workshop co-organised with @imbmainz.bsky.social focused on building a strategic approach to research funding for postdocs. We’re proud to stand behind our postdocs as they shape the future of research! #PAWde #PostdocAppreciationWeek2025 #IMBMainz

Are you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs

#Jobalert 🚨: Please RT ! Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ? #epigenomics, #epigenetics, #metabolism www.helmholtz-munich.de/en/ife/job-o...

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

“In bone marrow alone ~500 million cells are born every min” says Bruce Stillman. Each must duplicate 2+ meters of DNA to avoid errors that can cause cancer & autism. See more from Stillman, @crick.ac.uk’s John Diffley & @uuhsresearch.bsky.social's @jiwasa.bsky.social www.cshl.edu/licensed-to-...

Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.bsky.social: “Just bypass it: mechanisms of DNA damage tolerance” 🔗 doi.org/10.1016/j.ti...

🎉 Join us at the upcoming GfG Symposium "Epigenetics & Chromatin" in Giessen, Sept 24–26, 2025! Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members. Please RT! express.converia.de/frontend/ind...

📢 Advance Your Career: Apply by July 31 to speak at the #TalentForum at #HelmholtzMunich! #PostDoc aiming for a group leader role? Present your work in #Epigenetics & Nucleic Acids Research and connect with leaders in the field. 🗓️ Nov 18–19, 2025, Munich ⏳Deadline: July 31, 2025 👉 t1p.de/n2n2r

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

A day well spent at the 2nd Life Sciences Postdoc Symposium. Thank you to our speakers Christian Tidona @biomedx.bsky.social, Eckhard Thines @unimainz.bsky.social, Marie-Theres Weil #BioNTech & Verawan Boonsanay-Michel #sanofi for their inspiring contributions. And of course to all our participants!

2nd Life Sciences Postdoc Symposium Mainz - Connect, learn & grow with fellow postdocs & staff scientists from Mainz, Frankfurt, Darmstadt & the region! 🔬 26 June 2025 ➡️ www.imb.de/postdoc-symposium25 Join us to strengthen your scientific network & exchange ideas with your peers. #postdoclife

The 2nd Life Sciences Postdoc Symposium in Mainz is happening this week! Registration is still open! www.imb.de/seminars-mee... #postdoc #postdoclife

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬 More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Happening next week, 26 June! And registration is still open ➡️ www.imb.de/postdoc-symposium25

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

Our members came from Mainz, Frankfurt, Darmstadt, and Munich to Würzburg for this retreat to discuss, network, and plan for the next years. We also took the opportunity to visit the Würzburg Residence and immerse ourselves in the art, culture, and history! #würzburg #SFB1361 #retreat