Wow! 167.2 Gb HiFi yield from a PacBio SMRT cell🎉 Are we getting close the record? This run was for the “Genome of Sweden” project, where we're building a national reference dataset from 10 year old biobanked DNA samples🧬🧪

Holy shit moment. Good statement. The corrupt authoritarians and oligarchs are at the gates. There’s no alternative to fierce resistance and putting down their lawless crusade against the American Republic. x.com/federalreser...

Hey people! My son's science fair project is about how people visualize things when they read. It's very short and he'd appreciate it if you could fill it out, and share for more responses! (info: 'print books' also includes ebooks) Thank you! ☺️ docs.google.com/forms/d/e/1F...

Sequencing Instrumrnt Outlook 2026 My observations & predictions on sequencing instrument companies 🧬🖥️ omicsomics.blogspot.com/2026/01/sequ...

There is always so much more to learn about Albert Einstein as a person. Such a good guy. Hopefully this link will allow sharing of this fondly-written piece about his life in Princeton. www.theatlantic.com/culture/2026...

New year new office layout new plants 😍🤩

I love this concept, New York City as a “great processing station of Americanization.” I’m proud and lucky that my Jewish ancestors went through that processing station 100 years ago.

“Most of us live off Hope” Ever true 💔

Starting //// going

disturbing look at how Roblox prioritizes growth for investors vs safety for their users/concerns of their parents.Thanks for covering this @caseynewton.bsky.social and @kevinroose.com www.nytimes.com/2025/11/21/p...

Subtle differences in repeat motifs can cause drastic diff in disease onset: using @pacbio.bsky.social PureTarget amp-free identifies non-canonical repeats and its ratio assoc. with disease onset for Spinocerebellar ataxia type 10 (SCA10) www.neurology.org/doi/full/10....

It's not a foolproof plan but every political debate from now on should be a Normal Guy competition. Ask them to describe grocery shopping in detail. Talk about what it's like to have a friend

One of my earliest moments of radicalization was in 2005 when Larry Summers said that women biologically have less aptitude for science than men. Following that, scores of equally unimpressive people wrote pieces trying to explain or justify his remarks, when they should have called for his removal.

I was a grad student at Harvard when Larry Summers said the reason women were underrepresented in science was natural aptitude. Love to see this news.

Something absolutely perfect about Larry Summers riffing about the scourge of woke cancel culture being unfair to predatory men in a friendly email to his pal JEFFREY EPSTEIN.

Rep. Adelita Grijalva (D-AZ) is FINALLY sworn in and is now officially a member of Congress.

It's been 50 days since Adelita Grijalva was elected by the people of Arizona's seventh congressional district to represent them in Congress. She'll finally be sworn-in today.

BIG NEWS: Congresswoman-elect Adelita Grijalva will finally be sworn in as a member of Congress tomorrow. She is likely to be the 218th vote on the Epstein discharge petition, which would force a full vote to release the Epstein files in their entirety.

This is nearly at 47k signatures, by the way. Join us.

Oh look, we’re already on it!

I think democratic voters need to wage a pressure campaign to get rid of speaker @schumer.senate.gov talkingpointsmemo.com/edblog/with-...

BREAKING: Colorado voters approved a ballot measure that would raise state income taxes on higher-earning households to fund free meals for all public school students. Follow AP for live updates.

This 👇👇👇

I do think yesterday’s results reinforced the dynamic that while much of the American leadership class is chickenshit, most of the electorate is not

If I were running the DNC, there would be Democratic Party sponsored food relief banks across the country right now that specifically welcomed anyone regardless of party affiliation. Along with the food, there could be voter registration and links to runforsomething.net

[The No Kings demonstrations] make clear that Donald Trump’s conquest of the American Republic is far from complete and is in fact unlikely to ultimately succeed.

The following is REAL footage from Portland, 2025. Viewer discretion is advised.

This is the correct response. Expose the MAGA narrative as a lie. Make MAGA look weird again.

I feel like this photo of masked, armed men pepper spraying a pastor protecting his community is going to be a defining picture of this moment in America for a long, long time.

@mollyschumer.bsky.social if the data is pre SPQR chemistry I would recommend fibertools. If it’s new data then you can use Jasmine from Pacbio, Andrew and I spent a fair amount of time looking at the Jasmine results and they look good. And it will all still work with downstream fibertools commands

Did you know? Revio & Vega include on-instrument 6mA calling for the Fiber-seq chromatin accessibility assay. Thanks to Fiber-seq expert @mrvollger.bsky.social for the thoughtful evaluation and recommendation. Reagents for the assay are also available from our friends at EpiCypher: bit.ly/42YwGQE

I really appreciated this thoughtful piece about Ta-Nehisi Coates & Ezra Klein. Andrea Pitzer says “lost” folks like Klein “don’t have a clear idea how this moment fits into history and what it is exactly that they’re doing”. [degenerateart.beehiiv.com]

I'm super excited to announce the new PureTarget kits from @pacbio.bsky.social are out! We have a new carrier screening panel and updated repeat expansion panels plus variant calling software to support both. Press release - www.pacb.com/press_releas...

Doooooom is back! I’m going to be a panelist for Oral History Live! Roundtable with Boston Roller Derby. It’s the 20th anniversary of the league I helped found. It’s a virtual event, you can sign up here www.eventbrite.com/e/oral-histo...

Breaking News: A federal appeals court upheld a decision that temporarily halted agents from arresting and detaining L.A. immigrants without probable cause.

Quest Diagnostics launched a new test for ataxia using long-read sequencing based on the PacBio #PureTarget method. It can uncover hidden genetic causes of disease, including repeat expansions often missed by other tools. Details here: bit.ly/4fcu4DV #PacBio

Some exciting professional news: Athena Diagnostics, Inc. developed an LDT using PacBio's PureTarget technology (my product!!) and HiFi sequencing on the Revio, which improves Ataxia Diagnostics for some of the most challenging genes in the human genome. Read the press release here: lnkd.in/g-ec-ECq

🚨Federal judge orders DHS to limit “roving patrols” in Los Angeles. The judge finds that the evidence shows that DHS officers are racially profiling people to demand their papers, which all sides agree is illegal, and orders DHS to stop those unlawful practices.

10 days relief from indiscriminate terror www.nytimes.com/2025/07/11/u...

Harvard sociologist/polisci Theda Skocpol explains how the vast expansion of ICE in BBB may be Trump's secret weapon to overcome the barriers of federalism and complete his autocratic takeover of the American state. (History from Germany & Hungary in 20s/30s.) talkingpointsmemo.com/edblog/criti...

The Tea Party protests in April 2009 had about a third of a million people involved, and the political media treated it like a game changer for the Obama presidency. The No Kings rallies were AT LEAST ten times bigger than the Tea Party protests. Will the press keep pretending Trump is popular?

Ahead of tonight’s Angel City match, the club stands with the city of LA. Fans found these shirts at their seats and together with the players are showing that Los Angeles is for everyone ❤️ 📷: @angelcity.com

My favorite #Wisconsin #NoKings sign/flag from today. #wipolitics

So proud to be a part of this amazing morning. Location ocean beach San Francisco #nokings

Big turnout at #nokings in #sanmateoCA #nokingsprotest @50501movement.bsky.social @joshtpm.bsky.social @indivisible.org

Possible to start to tell a unified story: "Trump is personally too old, crazy, and confused to run things, so at any given time the question is which co-president is in charge. At first it was Musk, & we got the crazy chaotic DOGE era. Then Navarro: a trade war that crashed markets. Now Miller..."

Breaking: A federal judge halted President Trump’s deployment of California National Guard soldiers in Los Angeles, finding that he broke the law in ordering them to put down urban unrest without consulting Gov. Gavin Newsom. cal.news/4l4l7y9 📸 Ted Soqui

this should be unlocked www.wsj.com/us-news/prot...