A cadre of former colleagues is developing software tools for tracking designed genome edits, propagating annotations to the edited genomes & aligning in a graph-aware manner to assess the success of editing If you are a synthetic biologist, you should check it out bsky.app/profile/hofe...

Bell Labs Wasnt Built in a Day. Or Two Years. omicsomics.blogspot.com/2025/11/bell...

Another podcast host foolhardy enough to have me on! 🤣 Seriously, I thoroughly enjoyed the session 🧬🖥️ Ep 2: Evolution of Biotech with Keith Robison youtu.be/zu9P5T6GJPY?...

Nineteen - musings on shrinking the number of amino acids in a proteome 🧬🖥️ omicsomics.blogspot.com/2025/11/nine...

GitHub - meadm/GenomeCheck: Streamlit app within a docker container for carrying out genome QC and comparisons Written by a great colleague who is hunting for a new gig github.com/meadm/Genome...

Bacterial telomeres are common, just not so much in RefSeq 'complete' genomes. But they can be added by the new tool David Faurdal wrote. I am thrilled to see this out as a preprint here: www.biorxiv.org/content/10.1... @tilmweber.bsky.social @thombooth.bsky.social

Many antiphage systems use NAD+, in many ways. @hugovaysset.bsky.social reviewed them all! Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity! www.cell.com/molecular-ce...

Long-form complaint about the #ASHG25 event info system from @omicsomics.bsky.social omicsomics.blogspot.com/2025/10/ashg...

The link to download all abstracts is here. It's always a little well hidden. In previous years it was somewhere like a "Resources" page where no one would ever think to look. #ASHG25 www.ashg.org/wp-content/u...

Roche will price Axelios 1 at $750K in US Not yet releasing consumable cost #ASHG25

ASHG Posters: The Agony and The Ecstasy #ASHG25 🧬🖥️ omicsomics.blogspot.com/2025/10/ashg...

I wish the posters were up for more than a day, easy to miss a bunch PS, I was told official tag is #ASHG25

Ultra-sensitive DNA sequencing maps mutations that precede cancer. #DNAseq #Sequencing #GeneticVariants #CancerMutations #Genomics @nature.com 🧬 🧪 www.nature.com/articles/d41...

PacBio: $300 Genome Via Chemistry Update 🧬🖥️ omicsomics.blogspot.com/2025/10/pacb...

Find me at #Ashg2025 wearing an #Agbt hat - wonder if I can acquire haberdashery to perform the reciprocal next February in Orlando

From @plos.org #Computational #Biology | Ten quick tips for developing a reproducible #Shiny application | #Bioinformatics #Education #PLOSCBQT #OpenScience #OpenSource 🧬 🖥️ 🧪🔓 ⬇️ journals.plos.org/ploscompbiol...

The number of poster abstracts for #ashg2025 is bonkers Great there is so much information flowing from labs, but going to be hectic trying to even visit the subset with most enticing titles!

UPDATE: I saw it happen! At the Birds Canada research station at the tip of Long Point I watched an expert ever-so-gently and carefully put one of these tiny tags on a monarch. Let me walk you through the steps (1/4)

Very cool. www.nature.com/articles/s41...

Whole genome sequencing with AVITI and NovaSeq X Plus reveals comparable performance with contextual biases https://www.biorxiv.org/content/10.1101/2025.10.10.681584v1

Journalist here I’m interested in talking to a federal agency scientist who was fired, then rehired. I can keep you anonymous. I’m on Signal ginnyg.04 Reposts are appreciated!

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

My spouse pulled data from the CDC’s MMWR team on a weekly basis for her company to include with public health reports. That entire team has just been RIFed by Trump. No more public health reports. www.cdc.gov/mmwr/index.h...

Omics! Omics!: Ship of ThesION 🧬🖥️ omicsomics.blogspot.com/2025/10/ship...

Some thoughts on the blossoming of genomic medicine stimulated by the excellent @ga4gh.org meeting in lovely Uppsala Sweden. www.linkedin.com/pulse/though...

Oh look, AMR warriors, a beer for us.

Missed opportunity to call this movie “And now for something completely typeless”

The Trump administration has deleted all previous National #Climate Assessments from government websites and fired the scientists working on the next report. Now they say they're going to rewrite the previous ones. This is scientific sabotage and a rewriting of history. www.cnn.com/2025/08/07/c...

omicsomics.blogspot.com/2025/08/10x-... 🖥️🧬

My quote of the day The factory of the future will have only two employees, a man and a dog. The man will be there to feed the dog. The dog will be there to keep the man from touching the equipment. Warren Bennis

Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...

After 15 years of controversy, @science.org retracts ‘arsenic life’ paper

"Higher education policy in the United States is now being developed through ad hoc deals, a mode of regulation that is not only inimical to the ideal of the university as a site of critical thinking but also corrosive to the democratic order and to law itself." #AcademicSky

rna.ginkgo.bio/blog/circula... CIRQ has launched! Customers can now order our circRNA to screen in own lab (10 designs, starts at $50,000), or 3 month long design and screening project at Ginkgo (50 designs, starts at $300k)

"In the letter, the signatories warned that National Science Foundation grants now underwent a 'covert and ideologically driven secondary review process'...” www.nytimes.com/2025/07/22/s...

Well that's interesting.... here "pooling" refers to cofolding multiple proteins all at once and then assessing their pairwise ipTMs as shown in this figure from the preprint, never thought of doing that before and remarkable that it actually works *better* (I guess you'll need lots of VRAM though)

Ginkgo has launched an E.coli-based Cell Free Protein Synthesis reagent! reagents.ginkgo.bio/products/cel...

NYT reported the passing of Franklin Stahl Invest 20+ minutes of your time in this masterful documentary on “the most beautiful experiment in biology” as two friends joyfully relate how as young graduate students at they were entrusted with testing the Watson-Crick model youtu.be/7-tnuAqEp9g?...

You hear this a lot on the left but it isn't true. USAID did not "fail to tell its story to Americans," the right targeted the agency with lies and misinformation. Ultimately this narrative turns conservative attacks into even more calls for the left to reform. www.nytimes.com/2025/06/29/o...

Seriously. You know who has *great* messaging? Cancer researchers! Literally curing cancer! Sells itself! Still got fed to the DOGE woodchipper. FEMA and the National Weather Service got fed to the DOGE woodchipper, too. Nobody thought poorly of them until the right did the thing they always do.

Coukd It Have BEEN Found With Short Reads? 🧬🖥️ omicsomics.blogspot.com/2025/06/coul...

Food For Thought On ONT's Proteomics Push 🧬🖥️ omicsomics.blogspot.com/2025/06/food...

A process server delivered a letter regarding my "hostile" and "defamatory" attacks on #ColossalBio co-founder Ben Lamm, insinuating I'm a misogynist and a failed scientist. Nothing I've said is defamation, but you can read it a judge for yourself. I've redacted my home address 1/n

Updated a broken link in my substack post about the #ColossalBio #DeExtinction #DisInformation campaign – dire wolves are still extinct. open.substack.com/pub/devoevom...

How profoundly sad. The kids deprived of reading Calvin and Hobbes are the kids who need them the most. My brother put it best: "We know we’re fucked when they come for your cartoon stuffed tigers." Let's go sit in the grass and crack open "The Days are Just Packed." pen.org/magic-tree-h...

Defining ultra-slow-growing extremophilic microorganisms as aeonophiles #USC_earth #USC_MEB #jcampubs www.nature.com/articles/s41...

Now published! Note that since Vikram's original post (quoted here), he's made it easy to dynamically update a set of multi-MUMs (e.g. when more genomes are added to a pangenome) and to find multi-MUMs for huge collections like HPRCv2 genomebiology.biomedcentral.com/articles/10....

Had a fun chat recently with Kevin Libuit on his The Bioinformatics Lab podcast on.soundcloud.com/2hxiS7sDlK0x...