Subtle differences in repeat motifs can cause drastic diff in disease onset: using @pacbio.bsky.social PureTarget amp-free identifies non-canonical repeats and its ratio assoc. with disease onset for Spinocerebellar ataxia type 10 (SCA10) www.neurology.org/doi/full/10....

PangyPlot: a new #bioinformatics tools for visualizing pangenomes that supports linear coordinates and large graphs. Applied to @pacbio.bsky.social HiFi genomes to visualize two cystic fibrosis-relevant region not possible to resolve with short read genomes. www.biorxiv.org/content/10.1...

How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...

New @pacbio.bsky.social #bioinformatics spotlight video is up! SQANTI-QC: a multi-sample long-read RNA-Seq QC tool! Demo included. Check it out and give it a try! www.youtube.com/watch?v=83XL...

A new multi-center study from the EMEA HiFi Solves Consortium shows the clinical research potential of HiFi. Combined with our latest informatics pipeline, HiFi identified 100% of clinically relevant variants across 11 complex regions, including those short reads missed. 👉 bit.ly/4oqMWCY

Wonder how @pacbio.bsky.social long read sequencing is transforming how clinical and translational labs approach genomics? Hear from panelists from Myriad Genetics, GeneDx, Karolina and Radboudumc discuss rare disease testing, carrier screening, and more! programs.pacb.com/l/1652/2025-...

Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...

Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.

How does @pacbio.bsky.social long-read sequencing and AI interact to assess AAV genome integrity? Find out at this Catalent webinar on 10/29! event.on24.com/wcc/r/509468...

Why it's good to incorporate @pacbio.bsky.social long-read bacterial WGS into routine hospital surveillance for AMR tracking: 540 multidrug-resistant Gram-negative bacterial genomes revealed extensive and previously missed plasmid-mediated transmission events. journals.asm.org/doi/10.1128/...

How do you prep 1,000 @pacbio.bsky.social Kinnex bulk RNA-Seq samples consistently? With @sptlabtech.bsky.social Firefly for automation! Join this @selectscience.bsky.social webinar next week to hear about it! www.selectscience.net/webinar/auto...

The human #microbiome holds enormous potential, but only if we can see it clearly. Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics. Secure your spot: bit.ly/4mYmK1G

If DNA sequencing technologies had dating profiles 😜🧪

Learn from about @pacbio.bsky.social HiFi and then have a chance to WIN some!

Rarely do I get this excited about a @pacbio.bsky.social Iso-Seq study! 🧠 Come hear how the Tripathy lab used long-read multiomics to study neuron development—finding new isoforms suggesting some non-coding ASD variants may disrupt splicing & protein function. programs.pacb.com/l/1652/2025-...

AI saves elephants from being hit by trains in India. You can use AI for good! 🐘💫 timesofindia.indiatimes.com/india/ai-sav...

Just released @pacbio.bsky.social Kinnex-10x GEM-X single cell data for both Revio and Vega! Go check out the updated app note and dataset URL! App note: www.pacb.com/wp-content/u... Dataset: downloads.pacbcloud.com/public/datas...

Project JAGUAR, led by the @sangerinstitute.bsky.social and Latin American researchers, aims to build the first immune cell atlas representing Latin American populations—addressing equity and ancestry in genomics. #PacBio is proud to support with #HiFiSequencing. Read the blog: bit.ly/4l63Kwz

#PacBio is contributing Iso-Seq data to the 1000 Genomes Long Read Sequencing Project using #Kinnex kits and the #Revio system. This data from 1,000 globally diverse samples will help advance transcript-level insights across populations. Press release here: bit.ly/4mdzHEe

A once-in-a-decade bloom of Chanel the corpse flower (Amorphophallus Titanum) at the San Francisco Conservatory of Flowers and I caught the very tail end of its 48 hour blooming span! 🌸🌸🌷🌷

Learn from the best @pacbio.bsky.social users on their tips and tricks! (fun fact: I interviewed Lutz but I'm behind the camera so you won't see me ;>)

Spotlight on the gut-brain axis A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine erictopol.substack.com/p/the-gut-br...

Deepest long-read RNA-Seq dataset for one single cell line, multiple time points + replicates using @pacbio.bsky.social Kinnex RNA kit! Wissel et al. show that Kinnex can be used for isoform quantitative analyses: www.biorxiv.org/content/10.1...

Really loving this live demo of our @pacbio.bsky.social Vega benchtop sequencer by the one-and-only Sterling Maurer. Vega is so simple...probably I can do it (but I shouldn't XD) www.youtube.com/watch?v=wK90...

If you're in the San Francisco bay area and is a 10x single-cell/spatial user, @pacbio.bsky.social will be at the UCSF Gladstone 10x Symposium next week! I'll be there too! Come learn how to power up your 10x data with long reads! tinyurl.com/2mev7pj6

Next week! Come learn how @pacbio.bsky.social HiFi enables IGH genotyping and near-full-length TCR/BCR sequencing for immunotherapy research! programs.pacb.com/l/1652/2025-...

So fantastic to see an all women panel at #PacBioPRISM today moderated by @magdoll.bsky.social. #HiFi #longreads @pacbio.bsky.social

@pacbio.bsky.social instrument lounge at PRISM San Francisco event today! Great talks this morning and now we’re moving into parallel workshops.

🔍 Another blurry challenge is here! It's Find Your Focus Friday. Guess what's hidden in the image to earn an entry. Tag a friend for double the entries! With #PacBio, #TheresHiFiForThat — clear answers from the start. T&Cs: bit.ly/3O3AfhD

It's @pacbio.bsky.social fairy tale Friday! Once upon a time, you do lots of PCRs to screen different ataxia genes. Now with PureTarget, you can do 20 genes at once, get repeat lengths, repeat sequences, and even methylation patterns!

If you're looking for a way to streamline your #PacBio full-length 16S workflow or just wanting to try it out before investing in purchasing barcoded FL 16S primer stocks, check out the #ZymoResearch Quick-16S Full-Length Library Prep Kit to get started! #longread #microbiome

New Kinnex achievement unlocked! 194Gb with Revio SPRQ! Well deserved @udelaware.bsky.social

In case you've forgotten about measles induced immune amnesia www.nbcnews.com/health/healt... w/ @michaelmina.bsky.social @virusesimmunity.bsky.social

"Don't just focus on gene expressions". Instead, you might find common mis-splicing patterns that aren't derived from SF mutations, is associated with prognosis, and may have therapeutic potential. Intrigued? Register for @pacbio.bsky.social webinar next week! programs.pacb.com/l/1652/2025-...

Sunday cafe reading! I sort of “won” this book from a recent @pacbio.bsky.social internal event and I’m greatly enjoying it! So much to think about on pursuing greatness, offering hospitality, and relationship management.

We've known about the gut-brain axis. Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...

@pacbio.bsky.social Vega in the flesh today at Stanford!! 😁

@pacbio.bsky.social Vega benchtop demo + office hour this afternoon at Stanford! I'll be there! Come hang out with us and check out Vega :-)

Bay area folks! Want a chance to see the new @pacbio.bsky.social benchtop Vega in person? Chat with me and other PacBio folks about HiFi sequencing? We're hosting a Vega showcase + office hour tomorrow at Stanford! Come say hi! programs.pacb.com/l/1652/2025-...

Happy Monday! Let's start this week with fairy tales! ONCE UPON A TIME extracting high molecular weight (HMW) DNA was difficult. But now, with @pacbio.bsky.social Nanobind extraction kits. you get HMW DNA in, and beautiful long reads -> genome assemblies out! 💫⭐🧪🧬 www.pacb.com/products-and...

A coworker sent me this this morning and cracked me up so much! 🧬🧪 xkcd.com/3056/

AIR-BORNE, @carlzimmer.com's new book, is an enthralling deep dive into airborne diseases. The colossal failure to recognize that #COVIDisAirborne is thoroughly reviewed. Our podcast erictopol.substack.com/p/carl-zimme... Open-access, with transcript and full video, + relevant links

AAV/gene therapy folks! Join me, @formbio.bsky.social and others in North Carolina next month to discuss all things AAV - including how @pacbio.bsky.social long-read AAV sequencing can help characterize and improve AAV vector design! www.formbio.com/2025-aav-sum...

Current AIRR-seq methods have limitations. At #AGBT25, Melissa Smith showcases how #PacBio highly accurate long reads provide the resolution needed to fully understand immune responses—paving the way for better immunotherapy and precision genomic medicine. #AGBTGM

Genotype matters. At #AGBT25, Melissa Smith explores how germline-targeted immunogens and IGH variation impact immune response. Highly accurate #PacBio long reads help reveal critical insights for immunogenomics and precision medicine. #AGBTGM

If you want to learn more about how Clareo Bio is changing the game with comprehensive immune profiling, come Ask Me Anything at the @pacbio.bsky.social suite at 10am! #AGBTGM

Last week, a video of a rare black seadevil anglerfish spotted near the ocean surface made headlines because anglerfish typically live in very deep waters. Dr. @sternarchella.bsky.social joins us to discuss the video and recent research on anglerfish evolution.

Epigenetics controls gene expression, but how do we see these modifications? Enter #PacBio Fiber-Seq—a groundbreaking method that maps DNA methylation & chromatin structure at single-molecule resolution. bit.ly/4gfQbrW#PacBio #AGBTGM #AGBT25

#AGBT25 is here! Stop by the #PacBio Hospitality Suite in Lanai #289 tonight—where innovation meets a luxe retreat. 🌊🌴     Stay tuned for details on how to win a mystery box at our #AGBT suite!