I'm constantly trying (/failing) to get this point across. If you're a trained expert in a field, then it may be worthwhile to question the scientific consensus of your peers. If you're not, the scientific consensus is absolutely the best you can do and it's arbitrary foolishness to disregard it.

Are there any R users working for the Australian federal dept of health? I’d love to hear from you! New gig, new people to meet :)

I think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.

I've been in SF for four days and on each day I've had multiple conversations where people (self included) express deep feelings, fear, wonder and worry about their skills being replaced or (this is less named explicitly but an assumed driver I think) no longer valued by others. Big threats to feel

was banging my head against a bug (VEP classifying my in-exon variants as 'downstream') that Claude Sonnet 4.5 fixed in about 5 minutes. I can understand the scepticism on LLMs being jammed into every corner of life, but there's merit in these tools

Reminder for everyone operating at situationally-diminished capacity.

Getting older is like being out on the ocean in the Ship of Theseus but then at some point the guys just decided against replacing the decayed parts.

The comments on this are all about how sweet it is and I feel insane. Using AI to make fake memories of your grandma with dementia and telling her they happened and then filming her reaction

Pipeline release! nf-core/oncoanalyser v2.3.0 - 2.3.0 - Spotted Nightjar! Please see the changelog: https://github.com/nf-core/oncoanalyser/releases/tag/2.3.0

I recently discovered Conventional Comments (conventionalcomments.org) for providing a pseudo-standard set of labels for feedback and just tried it for an article review and it was really helpful to specify issues vs. thoughts vs. suggestions, etc. Hopefully it's helpful for the authors too!

Join the Clinical Genomics Laboratory Community (CGLC) meeting on 24 November. This session will explore how artificial intelligence and large language models (LLMs) are transforming variant interpretation. Register for the meeting: us02web.zoom.us/meeting/regi...

You have to wonder if White House staffers are simply showing him AI videos at this point and he thinks it's reality.

Reminder: a large (2.5M+) sibling control study found "no evidence of increased risk of autism, ADHD, or intellectual disability associated with acetaminophen use". Precisely the kind of data that requires serious consideration before declaring mission accomplished. jamanetwork.com/journals/jam...

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

Breaking Google up was one of the last best hopes for preventing the free press from getting squeezed into oblivion and harvested into AI slop, and for saving the open web. The ruling that effectively lets Google continue operating as a monopoly isn't just disappointing, it's a disaster.

At scale, the way that we store (and process) data matters! Many may think that the way we keep data, the file formats we adopt, and the way that we compress data are unimportant details, but they are, in fact, critical considerations to allow science to move forward at scale!

I do not know when or how this became a KPop Demon Hunters stan account, yet here we are www.billboard.com/lists/huntr-...

In case you missed it, this is fucked www.nytimes.com/2025/08/21/u...

He's gonna buy up the only remaining left leaning outlets, give them the WaPo treatment which means more people are gonna end up launching substacks and I'm gonna walk into the sea

happy birthday to bill watterson who gave me the gift of encapsulating my entire ethical approach in one comic panel.

It’s a good thing Congress isn’t alive to see this

I still can't get past the idea that people in America are now supposed to accept that this is a valid form of law enforcement and just assume it's fine when random dudes in groups with face-coverings, no ID, no warrant, & no uniform grab people off the street and force them into unmarked vehicles

this is a day for those of us who have spent the last six months terminally online. this is for us and honestly, we deserve it.

Do not give them an INCH! It's not: Well, maybe there are some areas where DEI has become too much a focus. It's: FREE COUNTRIES DON'T SEND OUT BANNED WORDS LISTS TO THEIR SCIENTISTS It's not: Well, science isn't perfect... It's: FREE COUNTRIES DO NOT HAVE SCIENCE COMMISSARS

We dodged right-wing populism this time because of Trump. We won't dodge it a second time if everyone's day-to-day living is still shit and the progressive side of politics hasn't offered real, courageous solutions.

one of the radicalizing incidents of my youth was when the NYPD brutalized a judge who was volunteering as a legal observer at a protest. I'm afraid that "Feds arrest judge" is the incident that has fully broken my brain

All the games I played on game day ranked. Top spot is Signal by @dvcgames.bsky.social In the game you’re experts trying to communicate with aliens. A great deduction game similar to First Contact but instead of words you work with objects. Really great fun especially if you’re drinking wine 😆

So, covid.gov now redirects to, uh, this... www.whitehouse.gov/lab-leak-tru...

From George Monbiot at the Guardian.

De-extinction is the carbon removal of biodiversity world Promises to magically undo the harm that in reality can only be prevented before it occurs.

If Colossal makes a horse with a midline horn and says they've made a mythical unicorn while cancer trials are being defunded, may self-immolate.

The problem is: they've mistaken correlation for causation. They think their parents and grandparents had a good life *because* of manufacturing jobs. When, in reality, their parents and grandparents had a good life *despite* manufacturing jobs, because of unions, high taxes, and social policies.

Hello BlueSky community! We are excited to be here. Stay tuned for news, announcements, and updates from GA4GH and the broader genomics and health community.

Successful integration of #genomics into healthcare needs whole-of-system change, a departure from traditional research models, & a strong multi-disciplinary approach. Key lessons from #AustralianGenomics are highlighted in @natmedicine.bsky.social @zornitza.bsky.social @stephaniebest.bsky.social

Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭

Welp they have a section on 1999 in the historical lives section of the museum I'm going to the grave bye

The most niche but also the truest meme in history

Good post by @rafalab.bsky.social on indirect costs and their impact on research, for anyone looking for arguments -- simplystatistics.org/posts/2025-0...

And Academic T&P committees, maybe take a beat & consider how the continuous & unsustainable push for CV conspicuous production has been a competitive inhibitor of scientists & scholars being engaged in their communities in meaningful ways as a bulwark to the shitstorm happening now.

This is the kind of simple and direct message we need right now: long-term damage aside, this attack is going to very quickly make it even harder for people to have the jobs and medical care they need.

I am no longer living in the US but the news is just demoralizing -- which is the point. Liz Neeley's "Making Sense of it All" great blog is helpful not just to avoid doomscrolling but also because she provides pointers on what to _do_ without cynicism or despair. buttondown.com/liminalcreat...

University leaders have not been especially vocal about the new administration *because* they were so worried about Trump just gutting the research infrastructure. And now they have done so anyway.

Are the next 4 years really going to be logging on everyday to sentences like "a 19 year old doge intern called Big Balls has your social security number" because I'm already at capacity for this sort of thing

This is a call out to bioinformatics developers that we are working to get all of NF-Core pipelines (and by extension most of Bioconda) to support Arm. Spot price for c8g.16xlarge (Graviton4) and it is below 60¢/hr. Or < 1¢ per physical CPU if your application supports Arm ...

This headline is *chef's kiss* @jasonkoebler.bsky.social www.404media.co/openai-furio...

Super impressive work by @angelp.bsky.social and colleagues at AWS / ARM on porting #Bioconda packages to #arm64 - there's potential for some big savings on compute as we scale this up! Check out the @nf-co.re #arm64 channel for more and to get involved in the effort...

I am looking for a mentor for the rust programming language. My latest issue is with trait bounds (github.com/brentp/simpl...) but I have a few things I generally hit. I can compensate with $$ or interesting problems. :) Please share with relevant people and feel free to DM.

A new interactive online tool developed by Australian Genomics provides easy and accessible information in bite-sized chunks to guide patients through the key concepts of genomic testing. Learn more: www.australiangenomics.org.au/new-online-c... #genomics #genomictesting #consent #onlinetool

When I meet an FDA person at a conference, I can't even buy them a cup of coffee. And these guys walk right in, obtain access to government information and get to make restructuring proposals? It's insane. www.nytimes.com/2025/01/12/u...

It seems 2025 will be very unsubtle with its metaphors and foreshadowing.