Yep

Off to BioIT in Boston this week. Mainly to catch up with as many biotech folks as I can so we can figure out a way through this AI transformation together.

current status

Thought of the day - striving to be the better person (taking the high road, turn the other cheek, etc) is hard sometimes. Sometimes you want to be petty but you know it’s not good for you in the long term so you hold back. Honestly I don’t know what is better but that’s how I operate

Wrote a quick blog on LinkedIn about some thoughts I've been having. www.linkedin.com/pulse/some-t...

2 years ago I went to bed feeling great, woke up next morning with a painful ear and hearing loss (which became permanent). Because of a shingles infection in my auditory nerve. Get the vaccine if you're eligible www.wired.com/story/shingl...

I decided that this year I will be going back to my bioinformatics roots and working on ML in life sciences. I’ve been one step removed from the fray for a little over 5 years so it’ll be interesting to dive back in and see what’s what.

Nice thread summing up what everyone is going through right now.

Springtime Funtime

Testing out Gemini for coding up a native macOS app for tracking espresso profiles, beans, etc. Should be interesting. Need a name for it though. Current front runners are “Grounds Control” and “Brew Base”. Suggestions welcome.

Another pic because this tree is awesome.

Annual weeping cherry bloom

Project Hail Mary was a really great movie adaptation from the book. I agreed with a lot of what they needed to edit out for time, but it did lose some of the deeper character development as a result.

Yep.

Loooooool

😍

In these trying times, you gotta celebrate small enjoyments where you can: 1. I painted my home office, put up all the prints and decorations I have wanted to do since moving in two years ago. Added a hammock for thinking deep thoughts. 2. New espresso machine is on the delivery truck! So excited.

TACO Monday

Painting crown molding sucks. That is all.

Tired of winning

I get yelled at for saying this but for many hundreds of years people went to university not to get diplomas or be employable but because immersion in the humanities was considered foundational to a good life, and school must return to its original purpose: the joy of learning.

VIX going to go to 50 this week

we have saved daylight but at what cost

Anyway, it's weird that they are saying conversations kids aren't ready for when so many kids movies center on the death of a parent. IDK, I'd rather talk about gay people then about death to a small child.

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

Tool A gets compromised. Tool A installs Tool B. Tool B does whatever it wants. If you're running AI bots in CI/CD that touch secrets and process untrusted input (issues, PRs), you're one prompt away from full pipeline access 😅

Yep

While in Largo Florida this past week I came across D.O.D. Coffee and they had a batch of fresh Geisha beans for sale. Supposedly one of the finest (also $$$) beans in the world, had to try it. Just made an espresso and WOW that is a unique flavor in a good way. 10/10. Will try pour-over next

But Crockett supporters are the ones who are racializing the campaign? Deeply unserious. Whether y'all are ready to accept it or not, you are in a war against racist. Many of the strongest leaders in this war, are Black women. Crockett was speaking with conviction while others were mealy mouthed.

Trump Suffers Setback Unrelated To Child Rape

First listen to The Protomen’s Act III album. Holy shit.

Schumer: ball’s in your court Republicans: stab the ball, tear it apart, set it on fire, rip up the court and sell the turf to Bahrain Schumer: hey you guys are out of balls Republicans: we’re gonna kill your families Schumer: ok we’ll pass funding for new balls but you’ve GOT to read the rules

New grinder. ☕️

New hobby is looking for weird shit on AliExpress. Current rabbit hole are wacky sneakers.

Abolish ICE. There’s no reforming it. There’s no compromise. There’s only one way to rein in ICE’s terror campaign. Abolish it.

Shaun King aka Talcum X aka (insert your favorite moniker here) is Shaun Kinging again, on Substack, writing ICE-related stories. Please do not support him. He's a serial grifter. He promises he's 'working hard behind the scenes'. He's not. He's just taking your money.

Python-Blosc2 just became a compute powerhouse. ⚡️ v4.0 integrates `miniexpr`: computing on cache-friendly blocks instead of RAM-heavy chunks. 🚀 Result? Massive speedups for memory-bound tasks (up to 4.5x in Cat2Cloud). See benchmarks: ironarray.io/blog/miniexp... #Python #HPC #DataEngineering

Today’s wordle given what’s going on at Amazon is something else.

Drones, excavators, and a dash of AI magic - our latest blog post takes you on a journey through the cutting-edge world of 3D world modeling and scene interpretation. Prepare to be amazed as we unlock the secrets of optimizing mining and construction operations. aws.amazon.com/blogs/hpc/en...

Curious about how Adobe handles massive data throughput and scales inference workloads efficiently? Check out our latest blog post on how they use AWS Batch with EC2 GPUs to enable their large-scale AI infrastructure. aws.amazon.com/blogs/hpc/ho...

Best part of searching for TACO on a day like today is seeing all the nice taco pictures.

New article! On life, death, and the rampage of ICE. sarahkendzior.substack.com/p/a-shining-...

I am honestly astonished at how much better the average home espresso grinder is compared to when I was first shopping 7 years ago.

Please don't ask me why my brain works like this, because I don't have an answer

A competent opposition political party would cut together the footage of what ICE had been doing in the twin cities with Mike Johnson saying "ICE is doing what ICE is designed to do" and have it in ads all across the country

Seeing Zohran instantly getting a bunch of shit done in like a week makes you realize that politicians could always do that on some level if they wanted it bad enough and very few of them actually do.

May start another polymarket on whether I break down and buy a temporary espresso machine to hold me over until the new one shows up.

The morning sky is a nice shade of lilac today.

Waiting on two espresso kickstarters to deliver. Considering setting up a polymarket to see which delivers first.

Optimize your Nextflow workflows on AWS Batch by leveraging Mountpoint for Amazon S3 to stream reference data directly into your processes, eliminating the need to stage large files repeatedly. Learn more in our latest blog post. aws.amazon.com/blogs/hpc/op...