View our new grid selection guide here: www.quantifoil.com/grid-selecti... Find the perfect support for your project and reach out to us here for a quote: www.quantifoil.com/request-quote #CryoEM #StructuralBiology #SingleParticleAnalysis #electronmicroscopy #CLEM #DrugDiscovery #InSituTEM

Tereza shares how switching to HexAuFoil grids gave her a 1Å resolution boost on a sub-100kDa membrane protein - while collecting less data and using fewer particles. Learn how these grids simplify prep, improve reproducibility, and optimize Titan Krios setups. www.youtube.com/watch?utm_co...

Come join us at #MM2025 Quantifoil booth 1641 and test your #cryoEM skills with our "sample Prep" Darts game, highest score over the meeting wins a $50 Amazon voucher. Zoe from Arizona is currently leading but we are expecting a fierce competition!

Come join us at #MM2025 Quantifoil booth 1641 and test your #cryoEM skills with our "sample Prep" Darts game, highest score over the meeting wins a $50 Amazon voucher. Game on!

We're excited to be back live and in person at ACA 2025 in Lombard IL with @sptlabtech.bsky.social - drop by booth 23 and get the latest news on #cryoEM sample prep with chameleon and HexAuFoil. #ACA2025 @acastructuralsci.bsky.social

Quantifoil and @sptlabtech.bsky.social Labtech are excited to be once again attending the CCP-EM Spring Symposium in Nottingham from 23-25th April 2025. We hope to see some of you there - but don't forget you can attend virtually if you can't make it in person!

and the Core Facility for Integrated Microscopy – CFIM – funded by @novo-nordisk.bsky.social where we collected our cryo-EM data on the first batch of newly developed HexAuFoil grids from @quantifoil.bsky.social

We spoke with Rectify about the first commercial use of HexAuFoil®, to gain new insights into the bile regulator BSEP. Our grids improved resolution by almost 0.5 Å, helping eliminate toxic therapeutic candidates. www.quantifoil.com/products/hex... #drugdiscovery #cryoEM

Catch them while you can! Available to ship now: HexAuFoil ultrasmall holey gold #cryoem specimen supports for better images every time. “If I need small molecule bound structures […] the HexAuFoils will be my go-to grids.” Imre Gonda - University of Zurich

With a revolutionary small-hole, all-gold design, HexAuFoil® grids deliver virtually movement-free imaging and exceptional uniformity in ice thickness. Watch our quick video demo: t.co/rD3OdXPL6o #cryoEM #structuralbiology #microscopy

6) We were able to achieve these structures using our newly developed (an)aerobic freezing protocol using the SPT chameleon. This allowed us to generate high quality girds with thin ice without having to be in an anaerobic chamber! www.biorxiv.org/content/10.1...

Final conference of the year and what a pleasure to spend it MRC LMB with BCA BSG Winter Meeting. Lovely day discussing #cryoem and #crystallography, and congratulations to Peter Harrison from eBIC for taking away the final grid race prize, with a fab 16 sec time!

This work is just our latest saga of tackling the complexities of the small heat shock proteins, following on our recent work with the human aB-crystallin that was just published: www.nature.com/articles/s41...

Thrilled to share our recent discovery from the Agrawal and Ojha Labs: an Actinobacteria-specific ribosome hibernation factor bound to Mycobacterium tuberculosis ribosomes isolated from biofilms. www.biorxiv.org/content/10.1... @cryoempapers.bsky.social @mycobacterium.bsky.social

Hello, Bluesky! To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper here www.nature.com/articles/s41... + movie

Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...

I’m guessing there has been a big influx of synchrotron and cryoem embedded synch people - shout out if you want to be added to this starter pack!

The grid-racing at GDR_Appicom 5th Plenary meeting was epic! In this beautiful location, we had a lot of very talented and very competitive #cryoem scientists competing for the prize. Including Irene Dossou of I2BCParisSaclay pictured here!

A peaceful sunset at Carry-le-Rouet on the last night of the wonderful 5th APPICOM plenary meeting, but keep your 👀 peeled tomorrow for a thread because the peace is hiding absolute scenes at the #cryoem grid racing!

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...

👇 Did you know one can use pulsed lasers not only to increase contrast in #cryoEM images, but also to reduce preferred particle orientation, by melting & re-vitrifying samples in a controlled way? ❄️🔬

Looking forward hearing the latest membrane protein updates from the APPICOM 5th plenary meeting next week with @sptlabtech.bsky.social - and delighted to provide an update on HexAuFoil #cryoem grids!

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project. www.science.org/doi/10.1126/...

5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:

Fantastic a couple of weeks ago to speak with Bharat Reddy of Rectify Pharma - his recent pre-print on BSEP is the first pre-print that uses commercially produced HexAuFoil #cryoem grids! 😍😎Listen to the whole interview: eu1.hubs.ly/H0dTfFZ0 #drugdiscovery

I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............

A post-doc position available to work in Raffaele Ieva and our group. See image attached for more details.

📄NEW PUBLICATION: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity (2024) @amiralito.bsky.social @adnroide.bsky.social @kamounlab.bsky.social @mauriciocontreras @JMadhuprakash www.science.org/doi/10.1126/...

Fantastic to see all the new #cryoEM peeps popping up here! So we think it's a great moment to share details for our latest HexAuFoil webinar, with Bill Rice (NYU) and Chen Xu (UMass) discussing using the grids with #serialEM and #Leginon. Register here: attendee.gotowebinar.com/register/694...

Just posting an update from the #PSDI2024 #cryoem Fastest Tweezers competition - astonishing scenes with Martin Polak from Eyen winning a closely fought contest, just ahead of Kerstin Kanonenberg and Stacey Southall - see you for next year's competition!

Repost appreciated: Open #PhDposition in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET with great #virology and #biophysics collaborators. Customisable project. Application deadline 15 December. More info: www.carlsonlab.se/join/

Thank you to all the lovely people who have already registered for our #cryoem webinar next week 😀 . But don't worry, there's still time to register here: register.gotowebinar.com/register/243...! Looking forward to seeing some of you there.

Want to get the best from the consistent, thin ice on a HexAuFoil #cryoem grid? Learn how in our 6 Jun webinar on optimizing data collection on ultrasmall holes, with Julio Ortiz, ThermoFisher Scientific, Peter Harrison, eBIC, UK and Felix Weis, IBS, France attendee.gotowebinar.com/register/243...

Delighted that our wonderful development scientist, Johanna Zessin, was able to attend #PICO2024 celebrating 20 years of the Ernst Ruska Centre. The Kasteel Vaalsbroek is a stunning setting and we hope the other attendees found the conference as rewarding as us!

"The amount of real estate is crazy!" that's what Nicole Chiang from NanoImaging Services said when she saw the 9 million holes of thin, consistent ice on HexAuFoil #cryoem grids. How will you react? Try them today and find out: www.quantifoil.com/resources/he...

It's not #Caturday yet, but we wanted to share this image of the Quantifoil cat modelling the purr-fect hat from @sptlabtech.bsky.social with our #cryoem friends as soon as possible!

The scaffolding is down on our new #cryoem grid facility! But that's not all - there's lots more happening inside as we begin the countdown to move in down. Learn more at our new blog: www.quantifoil.com/news/new-bui...

Great week at the #cryoEM 🔬 conference with @sptlabtech.bsky.social ! Excited to see so many at our booth (even after hours!) and workshop. And is that EMBL getting in on the #HexAuFoil vibe?😉 If you're feeling the excitement as well, why not try them today: www.quantifoil.com/resources/he...

Off to Heidelberg with @sptlabtech.bsky.social in just a couple more days now! Looking forward to seeing some of you there, and to talking about our exciting new #HexAuFoil grids!

Did you know there are an incredible 9m holes on every HexAuFoil grid? Request a quote from @sptlabtech.bsky.social and learn how our revolutionary ultrasmall hole #CryoEM supports deliver better images every time with consistent, thin ice: www.quantifoil.com/request-quote youtu.be/B85kdSheRxw?...

This is an interesting workflow where very small where magnetic beads are used to pull the target protein complex. Then the beads are pulled onto a cryoEM grid using a magnet on the back of a gold grid with graphene layer. After that, plunged using trad equipment. (h/t @klausenhauser.bsky.social ).

You always wanted a book on cryo- electron tomography, written by the leading experts in the field? I have good news-You can now pre- order this book, edited by Friedrich Förster and myself! link.springer.com/book/9783031...

Excited to be presenting a workshop on advances in #cryoEM grid technology with Paul Thaw and SPTLabtech at the EMBL workshop on #cryoEM in academia and industry event, in Heidelberg, 29-31 Jan. Look forward to seeing some of your there!