uhhh oh my god

Scientists: "Food gives you energy" Me after eating:

At our next meeting the #SalemMA School Committee will vote to name our newly configured elementary school the Sarah Parker Remond Elementary School. It will be the first school in Salem named for a woman and the first for a person of color. www.salemnews.com/news/local_n...

Full data published for orforglipron vs oral semaglutide in diabetics. Liver data looks good(which is the big concern with it's weird molecular shape) better A1c reduction is pretty clear. Tolerability slightly "worse" for orforglipron but otherwise another oral pill that just works!

Inspired by Lars I found this very recent publication, treat to target approach for obesity management. I feel like while some subjective measures remain, such as height & waist size, blood pressure this could honestly be a better way to measure GLP1 efficacy in both trials and clinics

it's fascinating to watch Costco lap every one of these clowns because they have the only CEO in America who still thinks his job is to run a company that does business and not be the main character of life forging his personal legacy with one eye on the group chat to see if they're impressed yet

oops. White nationalism is a helluva drug.

It's not often in Pharma that you run a head to head trial against your major competition and legit just flat out lose. Cagrisema 23.6% weight loss vs Tirzepatide 25.5% weight loss over 84 weeks. This result is horrid for Novo Nordisk.

Whoa, indeed!

Good. Also, fuck the Department of Education for attempting to pull this bullshit in the first place, and fuck this whole racist, shitty administration. And fuck ICE, while I'm at it, because that's just an evergreen at this point.

NEW: ICE has raided dormitories at the Dilley concentration camp to confiscate letters from children per @pabloreports.bsky.social. I have filed a FOIA request for them. @joaquincastrotx.bsky.social: the second we get anything, we will send it to you. 1/ www.muellershewrote.com/p/new-ice-co...

Old: Kids’ Letters To Santa New: Kids’ Letters Confiscated By Satan

And that's autoimmune disease #2 (plaque psoriasis) that improves with tirzepatide. The improvement is modest but apparently statistically significant and the trial was short, only 36 weeks so this is rapid improvement! A much longer trial is currently ongoing as well.

This was an interesting one to write, dual Amylin-Calcitonin receptor agonists (see: CagriSema) are a hot topic in obesity these days, but they're actually a bit of a mixed bag for diabetes thanks to calcitonin. Read on to find out why!

Adam’s right. It’s more important than ever that our institutions defend First Amendment rights, and that means not firing teachers illegally whether their offense was “Go ICE” or saying something less than hagiographical about Charlie Kirk. Fewer people want to hear that in ugly times. /1

OK Tracer Bullet was good but I assume we're all in agreement that this is the all-time BEST Calvin & Hobbes strip, correct

This is now a Dana fan account. Yeah, "Baby Jane Doe" was cute, but "Jag-off" and grabbing that guy's arm like he was trying to move her parking chair converted me fully.

The great actor Bud Cort has died. He was 77. Did you see Harold and Maude? Harold was Bud Cort. Maude was Ruth Gordon and they played lovers. He was in the movie Mash where he played Radar. Cort suffere terrible burns on his face but I never stopped loving him and his work. RIP Bud Cort.

Fascinating preclinical work on my favorite topic, glucagon. This study suggests glucagon is doing a lot more than just futile cycling glucose substrates and inducing ketogenesis & lipolysis for weight loss.

holy shit -- Bondi's new tactic is refusing to answer Democratic questions, then using time during the next Republican questioner to smear the previous Democratic member and accuse them of being complicit in violence crimes

There is literally no better example of textbook fascistic thinking than "Who cares about human rights when the rich are doing so very well"

Half an hour ago, Fox News hosted an "aviation expert" who argued such a closure wouldn't happen "unless we are at war" facing a "major security threat," and that it signaled the government "might have discovered the next potential Pearl Harbor."

Every once in a while the internet becomes that truly silly delightful thing it once was. Like this.

In continuing the theme of GLP-1s are overpowered Mary Sue drugs, we have our first glimmer they may actually rebuild cartilage in knee osteoarthritis. This tracks with some real life anecdotes I've seen here and in clinic @eecklund.bsky.social @stresshoop.bsky.social www.cell.com/cell-metabol...

Looks like Disney’s warning about fewer foreign tourists to the US was no joke. @financialtimes.com #$DIS www.ft.com/content/8f6d...

A publisher who lays off a reporter whose pen is freezing because she's covering a frigid war zone while dodging missiles is not an editor you want to work for, in a more perfect world

Wanted to do a quick GLP-1 update based on Eli Lilly and Novo Nordisk's earning calls today. It really highlights how one company has become overtly aggressive in the development of these medications while the other has stagnated. First Novo's pipeline update...which is sparse

This pup found a stick shaped like an old timey pipe earlier today and has already solved three mysteries. 13/10

The world may be falling into chaos and disrepair, but at least we have apples for me to review. New apple review at the blog -- WILD TWIST.

The fact that they made 36.5 BILLION DOLLARS IN REVENUE FROM ONE DRUG. Absolutely insane. And their drug pipeline is enormous for obesity/diabetes and they expanding indications. Not sure I've ever seen anything like it.

Forgive me, Jesus, because I genuinely deeply enjoy how perpetually unhappy and desolate these losers are.

PUNXSUTAWNEY, Pa. (AP) — we regret to inform you that Punxsutawney Phil is mentioned 35 times in the Epstein Files, including in the flight logs

This single payment is ~66x the total amount of “Biden family” revenues that the GOP and right-wing media spent years frothing over.” www.mediamatters.org/fox-news/ano...

Watch the video as a recklessly driven cheap car careens around and a gang of armed thugs spring out to menace an innocent civilian, like a kidnapping or robbery or murder-for-hire. It looks like organized crime taking place in a third-world country, because it is.

Also very Japanese American internment. So many family homes and farms seized for pennies on the dollar by white neighbors

It's a little depressing that every single critical patient on The Pitt has a better BP than I do.

Luther and the 99 Infrastructure Weeks

This is such a terrible mash up of buzz words, correlation not being causation and fear mongering. I was a phase 3 trial participant for retatrutide as many here know. When I say the trial sites practically asked about every single thing that happened to me I'm not kidding. Let me explain

Nerd hat on. Retatrutide + Bempedoic acid + telmisartan would probably utterly crush metabolic syndrome/obesity/DM2 if BA does indeed activate PPAR-alpha in humans. Quick thread on hypothetical synergies...

Well worth the read

one of the funniest things i’ve ever seen

This March 1965 Herblock cartoon about police violence against civil rights activists has added relevance today.

I have a lot of respect for people who work at the VA and I’m sorry they have to serve during this dickhead’s tenure.

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him. White. Hot. Rage.

Breaking MS NOW: Aides to Deputy Attorney General Todd Blanche directed the U.S. Attorney's office and FBI agents in Minnesota to shut down the civil rights investigation into the fatal shooting of Renee Good and instead alter it to probe Good for possible criminal liability.

"Slavery was real" Tiny sign at the base of a brick wall that, until yesterday, held panels about the people enslaved by George Washington. Presidents House, Philadelphia.

Exciting discovery! Mind you, I'm still hoping that we one day find a book written by a medieval housewife describing daily life in detail, especially about all the bathing they did ;) www.bbc.com/news/article...

Orin is probably the preeminent fourth amendment scholar in the United States. He is also extremely professional. This is the way he says "I wish a bitch would try"

She was absolutely right. And she would have been an amazing President.