@koenvervaeke.bsky.social
📤 187
📥 339
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reposted by
Alex
14 days ago
How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (
@deisseroth.bsky.social
)
doi.org/10.1101/2025...
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Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation
In novel environments, animals quickly learn to navigate, and position-correlated spatial representations rapidly emerge in both the retrosplenial cortex (RSC) and primary visual cortex (V1). However,...
https://doi.org/10.1101/2025.10.21.683723
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reposted by
Siri Leknes
about 1 month ago
Please RT 2 new positions in the lab as postdoc & PhD! Interested in stress, pain, or reward? This project has it all! We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶
www.jobbnorge.no/en/available...
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Postdoctoral Research Fellowship (286516) | University of Oslo
Job title: Postdoctoral Research Fellowship (286516), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
https://www.jobbnorge.no/en/available-jobs/job/286516/postdoctoral-research-fellowship
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reposted by
Jesper Sjöström
about 2 months ago
🧪 We got the privilege to write a Preview on the beautiful work of Morabito, Zerlaut, Rebola and colleagues that was recently published in Neuron.
www.sciencedirect.com/science/arti...
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Branch logic: Dendritic computations diversify inhibition
Long known for different circuit roles, parvalbumin and somatostatin interneurons are shown by Morabito et al.,1 in this issue of Neuron, to differ in…
https://www.sciencedirect.com/science/article/abs/pii/S0896627325005501?dgcid=author
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reposted by
Nature Reviews Neuroscience
about 2 months ago
Ripple contributions to human memory: making the spiking content count — a Review by Joel Reithler, Kelsey K. Sundby & Kareem A. Zaghloul
www.nature.com/articles/s41...
#neuroscience
#neuroskyence
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Ripple contributions to human memory: making the spiking content count - Nature Reviews Neuroscience
In animal models, transient high-frequency oscillations in synchronized neural activity, known as ripples, have been linked to memory. Reithler et al. assess the current evidence for a contribution of...
https://www.nature.com/articles/s41583-025-00971-w?utm_source=bluesky&utm_medium=social_&utm_campaign=nrn
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reposted by
Emre Yaksi
about 2 months ago
Check out this exciting study led by Anh-Tuan Trinh from our lab, where we investigated how thalamocortical-like circuits in the zebrafish pallium receive, represent, and integrate sensory information: 🔗
doi.org/10.1101/2025...
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Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain
Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from firs...
https://doi.org/10.1101/2025.09.15.675867
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reposted by
Markus Meister
about 2 months ago
Human intelligence is overrated and not a useful yardstick for AI - a polemic.
markusmeister.com/2025/09/15/w...
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reposted by
James Hyman
about 2 months ago
This type of textbook chapter review of neural manifolds has been so needed. Thank you for writing this. It's excellent.
rdcu.be/eGjAu
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A neural manifold view of the brain
Nature Neuroscience - Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds....
https://rdcu.be/eGjAu
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reposted by
Maximiliano José Nigro
3 months ago
Our first steps into sensory processing is now online! Work spearheaded by Rejwan Salih from experiments by
@prime5222.bsky.social
and François Pauzin We were lucky to receive guidance from Davide Zoccolan on the analytical methods.
#neuroskyence
add a skeleton here at some point
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reposted by
Siri Leknes
2 months ago
What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans? Fully funded position in Oslo (PhD student or postdoc) Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...
Please RT for reach
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Phd candidate or postdoc– Genetic determinants of opioid responsiveness
The Department of Research and Development at the Division of Emergencies and Critical Care, Oslo University Hospital in collaboration with Leknes Affective Brain lab (www.affectivebrains.com) and the...
https://2411.webcruiter.no/Main2/Recruit/Public/5008017264?link_source_id=0
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reposted by
Spencer LaVere Smith
2 months ago
This comment is 3 minutes long, and it's from back in February. It bears repeating. "Curiosity-driven, peer-reviewed research is not meant to pass the politician's test."
x.com/RepAuchinclo...
(1/2)
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https://x.com/RepAuchincloss/status/1894526013092004193
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reposted by
Ann Kennedy
3 months ago
Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing.
www.biorxiv.org/content/10.1...
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A piece of neuroscience history. The original "Oslo chamber", possibly the first one to be used for holding brain slices.
4 months ago
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reposted by
Simon Schultz
4 months ago
Has anyone got any experience with gcamp8 transgenic mice yet? Eg the Thy1-GCaMP8s line?
janelia.figshare.com/articles/dat...
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jGCaMP8 transgenic mice
The GENIE Project Team at HHMI Janelia Research Campus have developed and characterized multiple transgenic mice expressing jGCaMP8s and jGCaMP8m and deposited the lines at The Jackson Laboratory (JAX...
https://janelia.figshare.com/articles/dataset/Untitled_Item_b_jGCaMP8_transgenic_mice_b_/24565837?file=43777884
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reposted by
Matteo Guardamagna
4 months ago
Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in
@natcomms.nature.com
🔬🧠
rdcu.be/evWtz
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Direct entorhinal control of CA1 temporal coding
Nature Communications - Temporal coding in the hippocampus is thought to be key for memory and predictions. Here, the authors show that blocking one entorhinal input affects two aspects of...
https://rdcu.be/evWtz
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reposted by
Weijian Zong
4 months ago
Opening new neuroscience horizons: With this tool, we can study dendritic computation and network dynamics under naturalistic behavior: an essential step toward understanding the neural basis of cognition. 🌍🧠
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reposted by
Annabelle Singer
4 months ago
These insights enable stimulation “tuning” to target specific functions. This work also highlights how flicker stimulation has multiple biological effects and we think such a multipotent therapeutic approach is required for neurodegenerative diseases. This study was made possible by Levi Wood’s lab
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Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a c
https://doi.org/10.1063/5.0261497
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reposted by
Aaron Wilber
4 months ago
Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal | Science
www.science.org/doi/10.1126/...
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Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal
Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...
https://www.science.org/doi/10.1126/science.adv8269?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=SCIeToc&et_rid=336688728&et_cid=5671136
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reposted by
Dan Falk
4 months ago
Physicists have a lot to say about time, but so do neuroscientists -- after all, it's the brain which in some sense creates time, and enables our remarkable capacity for "mental time travel." I spoke with neuroscientist
@deanbuono.bsky.social
for
@nautil.us
:
nautil.us/does-anybody...
#science
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Does Anybody Really Know What Time Is?
Yes, your brain does. It created it.
https://nautil.us/does-anybody-really-know-what-time-is-1223272/
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reposted by
Poirazi Lab
4 months ago
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!
www.sciencedirect.com/science/arti...
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Distinct dendritic integration strategies control dynamics of inhibition in the neocortex
Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…
https://www.sciencedirect.com/science/article/pii/S0896627325004295
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rdcu.be/euiTe
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Brain region-specific gain modulation of place cells by VIP neurons
Nature Communications - Functional roles of interneurons in regulating the gain of place-tuned neurons are not fully understood. Here, the authors show that VIP neurons fine-tune brain circuits...
https://rdcu.be/euiTe
4 months ago
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reposted by
Peter Rupprecht
5 months ago
New blog post with a review of interesting papers on VIP interneurons in cortex and hippocampus:
gcamp6f.com/2025/06/23/i...
Covering work from
@koenvervaeke.bsky.social
's lab with
@mateneubrandt.bsky.social
, Yoav Adam's lab and Bernardo Rudy's lab.
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reposted by
Nature Neuroscience
5 months ago
Mouse retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming information to resolve ambiguities
@jvoigts.bsky.social
www.nature.com/articles/s41...
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Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex - Nature Neuroscience
Using a spatial reasoning task in mice, the authors show that retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming inf...
https://www.nature.com/articles/s41593-025-01944-z?utm_source=bluesky&utm_medium=social&utm_campaign=neuro
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Whether gamma stimulation is a silver bullet for Alzheimer’s remains to be seen. But it boosts glymphatic flow, immune signaling, and engages inhibitory neurons like VIP cells. Understanding the mechanisms could unlock its full potential.
elifesciences.org/articles/100...
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The gamma rhythm as a guardian of brain health
Fast oscillations (30-150Hz), generated by internal brain mechanisms may be essential for the maintenance of healthy brain function.
https://elifesciences.org/articles/100238
5 months ago
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We found time cells in the retrosplenial cortex—but not in neighboring areas. A new piece in the puzzle of how the brain keeps track of time.
www.cell.com/cell-reports...
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Area-specific encoding of temporal information in the neocortex
The retrosplenial cortex (RSC) is a brain region associated with episodic memory. Garvert et al. show that time-encoding cells are present in the RSC but rare in nearby neocortical areas. These findin...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00134-2
5 months ago
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reposted by
Takaki Komiyama
7 months ago
Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake!
www.science.org/doi/10.1126/...
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Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
https://www.science.org/doi/10.1126/science.ads4706
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reposted by
Ardem Patapoutian
7 months ago
From
@alexchesler.bsky.social
lab!!
add a skeleton here at some point
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reposted by
Martin Vinck
7 months ago
Firing rates in visual cortex show representational drift, while temporal spike sequences remain stable
www.sciencedirect.com/science/arti...
Great work by Boris Sotomayor and with
@battaglialab.bsky.social
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Firing rates in visual cortex show representational drift, while temporal spike sequences remain stable
Neural firing-rate responses to sensory stimuli show progressive changes both within and across sessions, raising the question of how the brain mainta…
https://www.sciencedirect.com/science/article/pii/S2211124725003183
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reposted by
Giulia Quattrocolo
7 months ago
So happy to share the second manuscript of the
#QuattrocoloLab
. This was a side project of a fantastic PhD student, Kristian Moan, that saw something cool in his data and presented it in our annual lab retreat in 2024. Now the whole story sees the light of day. 1/3
add a skeleton here at some point
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reposted by
Annabelle Singer
7 months ago
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning”
www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
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reposted by
Kepecs Lab @ WashU
7 months ago
1/ Why do patients with late-stage cancer lose motivation & sink into apathy? 🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵 🔗
doi.org/10.1126/scie...
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A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
https://doi.org/10.1126/science.adm8857
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reposted by
Kate Jeffery
7 months ago
OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...
add a skeleton here at some point
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reposted by
Davi Bock
7 months ago
Igor FTW, again! Amazing photographer, anatomist, microscopist, artist.
add a skeleton here at some point
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reposted by
Peter Rupprecht
8 months ago
Are you using GCaMP8 or are planning to switch from GCaMP6? Then check out this new preprint from our lab!
www.biorxiv.org/content/10.1...
- Calcium imaging - GCaMP8 vs. GCaMP6 - Spike inference - Imaging + ephys ground truth With F. Helmchen, K. Svoboda, M. Rozsa & X. Fang.
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reposted by
Neuropsychology
10 months ago
What sad news - Dr. Eleanor Maguire
#neuropsychology
#cognition
#memory
#neuroscience
www.online-tribute.com/EleanorMaguire
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Eleanor Maguire | 1970 - 2025 | Online-Tribute.com
Learning and memory are so fundamental to us, so enmeshed throughout cognition, that ‘solving’ memory, unpacking its neural mechanisms and being able to conceptualise it fully will, I believe, res…
https://www.online-tribute.com/EleanorMaguire
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