#photoswitches: How should we determine errors on PSS distributions, and the absorption spectrum of the metastable isomer? We have been discussing this for years and have finally written a manuscript, including a python code to fit your data without human bias. chemrxiv.org/doi/full/10....

Excited to see this study by the group of @dbkonrad.bsky.social out in JACS Au. Ortho-dichloroacrylophenone is a cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution. pubs.acs.org/doi/10.1021/...

🔓Don't miss this #OpenAccess review from @dbkonrad.bsky.social & co. at @univie.ac.at & @lmumuenchen.bsky.social, part of our New Talent collection providing their perspective on cysteine-reactive activity-based probes #orgchem #chembio Check it out in full here🔽

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA. Here is the link: stellen.uni-muenster.de/jobposting/6... #chemsky #chembio

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....

I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩

We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!

We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.

📢 Only one more week to apply!

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out! 👇 www.mls.ls.tum.de/tnm

So cool! 🤩

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬 onlinelibrary.wiley.com/doi/full/10....

DOGE By The Numbers theonion.com/doge-by...

A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs) Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues! www.nature.com/articles/s41...

Managing to score a professorship without a Cell, Science or Nature paper.

When grant writing is become so intense that you need to procrastinate a little by posting on #ChemSky.

PI had an important conference to attend...

Voting for our new government in 🇩🇪✔️

Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know go.bsky.app/EwimNbK

The "Fluorescent Probes, Sensors and Fluorophores" starter pack got substantial additions worth a new look. Please raise you hand 👋 in the replies if you want to be added too. go.bsky.app/MtgJE4w

We had the pleasure to host @dbkonrad.bsky.social today for a @unisyscat.bsky.social Colloquium! Thanks for the great scientific discussion, David! 🤩

What do you think about matching tattoos @dirktrauner.bsky.social?

Dear #ChemSky, I have an important question: Do I need to tattoo a permanent version of my PhD thesis onto my back?

Very excited to share our review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family", where we discuss their potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses: tinyurl.com/ye6nwnwu.

Very happy to share that SURF, our data format for chemical reactions, has been published by Molecular Informatics! SURF is a machine-readable reaction format that helps to bridge the gap between chemistry, data, and AI. Link: doi.org/10.1002/minf....

😍 kurier-at.cdn.ampproject.org/c/s/kurier.a...

Today, we report a role for hypoxia in brown adipocyte differentiation and function via hypoxia-induced miRNAs, so called hypoxomirs - when cells consume lots of oxygen - like brown fat cells - does that cause a hypoxia-like response? The answer is YES - www.mdpi.com/1422-0067/26...

Very excited to see our work on photoswitchable menthol (AzoM) to control the cold receptor TRPM8 published! Our chemical probe allowed the analysis of current kinetics, and the roles of individual amino acids in channel gating, AzoM binding and the modulation by PIP2. Link: doi.org/10.1002/anie....

Only 12 days left in 2024... Time to plan for next year! Please, save the date and join us for the meeting of the GBM Redox Biology Study Group @gbmev.bsky.social #redox #ros #signalling

The next development in photopharmacology (and "photogastronomy"). Controlling the Menthol Receptor TRPM8 with light! onlinelibrary.wiley.com/doi/10.1002/...

Only a few days left until the winter break 🙈😅

Our study on the partial reduction of arenes to cyclohexenes is now online in J. Am. Chem. Soc. Congrats to Kirti and Asad! pubs.acs.org/doi/full/10....

A platform for the development of highly red-shifted azobenzenes Authors: Kyra Lützel, Henryk Laqua, Judit Katalin Szántó, Gökcen Savasci, Lars Allmendinger, Bilal Kicin, Vincent Ruf, Konstantin Karaghiosoff, Ahmed M. Ali, Christian Ochsenfeld, ... DOI: 10.26434/chemrxiv-2024-9wbz4

We are moving one step closer to our goal to develop a general method to red-shift photoswitchable ligands as a foundation for in vivo photopharmacology with our latest work: "A platform for the development of highly red-shifted azobenzenes". Link: doi.org/10.26434/che....

Who wants a taxi when you can walk to the hotel in Amsterdam 🇳🇱? With @dbkonrad.bsky.social and Oliver Reiser! 🚶‍♂️🚶

Fantastic first dinner at the #PhotoReAct symposium in Amsterdam! With @lcsolab.bsky.social and @dbkonrad.bsky.social and others! #ChemSky

We kick off the PhotoReAct final symposium with David Konrad from LMU Munich #ChemSky

I am beyond excited to announce that I will be joining the Department of Pharmaceutical Sciences at the University Vienna (@univie.ac.at) as a Tenure Track Professor in March 2025! Thanks to the support of the LMU, I will also continue to work as a group leader in Munich for the foreseeable future!

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Job Alert - Our team @uni-jena.de is looking for a PhD student who wants to unravel how enzymatic modifications of natural products impact microbial interactions. This is a highly interdisciplinary project with great collaborations within the CRC1127 ChemBioSys! Apply here until Feb.04: t.ly/alya1

Anscheinend nimmt das US System die Ratschläge von #IchBinHanna ernst, aber das BMBF hat immer noch nicht verstanden, dass es nötig ist: " ... creating new funding opportunities for young life scientists ... who want to stay in academia but don’t want to become faculty." @amreibahr.bsky.social

Being a postdoc during the great postdoc shortage of 2023.

I had a great time visiting @Bayer in Berlin to give a talk on "integrating high-throughput experimentation with machine learning to unlock late-stage functionalization for medicinal chemistry" alongside so many fantastic speakers! Big thanks to Rob Webster for the invitation!

Thanks to the LMU for highlighting our work!

All good publications come in threes: A reaction screening approach combining High Throughput Experimentation with computational GNN to identify suitable substrates for late-stage C–H alkylation via Minisci-type chemistry, reported by LMU München, Roche Basel and @ethzurich.bsky.social.

I am very happy that I can finally share this work in its published form in Nature Chemistry: A platform for late-stage C-H functionalization in medicinal chemistry that integrates high-throughput experimentation with geometric deep learning. Link: www.nature.com/articles/s41....