Not quite an Earthset, but I’ll take it. #AACR

I'm very excited to share our newest preprint, where we show that long, linear bifunctional molecules like PROTACs can bind within the narrow ubiquinone-binding tunnel of mitochondrial complex I, leading to off-target mitotoxicity. www.biorxiv.org/cgi/content/... (1/4)

What are you waiting for? Go work with Elena!

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

paper alert🚨 Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry www.nature.com/articles/s41...

💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback." Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)

I can't believe I missed @dereklowe.bsky.social commenting on our @natchem.nature.com a month ago at "In the Pipeline". I've dreamt for many years that Derek would choose to highlight work coming out of the lab. That feels like a real stamp of approval. Thanks, Derek! www.science.org/content/blog...

Our Synthetic Genomics Center "SynGen" is looking for a coordinator, located at @kit.edu Karlsruhe, but coordinating also the U Heidelberg and U Mainz sites. We are hoping to fill this vacancy ASAP. For further info, please visit: www.syn-gen.de/en www.pse.kit.edu/english/karr... Please share 🙏

The most recent roadmap problem from our Synthesis Club is up on our shiny new website. This quiz highlights the synthesis of clionastatin B from the group of Jinghuan Gui. www.dkfz.de/en/cancer-dr...

Check out our paper on proton pump inhibitor activation (PPI) in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@redoxdkfz.bsky.social). More collabs between our groups to come! doi.org/10.1038/s415...

Congrats to Niki and the whole team for this new collaboration with Sanofi. www.linkedin.com/posts/dkfz-i...

Great opportunity to work with an excellent young group leader.

From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...

This week’s Synthesis Club quiz featured a total synthesis that one of our recent Master’s students contributed to as an intern in the US. Anyone recognize this beauty?

I had no idea Rodney Mullen, the Godfather of skateboarding, had studied Chemical Engineering. Thanks, Rodney, for putting two of my favorite things together on one slide. youtu.be/2c3aXbwM8L0?...

Starting what will hopefully become a regular feature here…our disconnection analysis of a natural product total synthesis from our biweekly Synthesis Club meetings. Anyone recognize this recent beauty? #chemsky

Congratulations to former PhD student Raphael Steimbach for winning the EFMC-Young Scientists Network PhD prize (www.efmc.info/ysn-phd-prize). Come see his lecture in Rome at #EFMC-ISMC in September. Congratulations Raphael!