Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...

Excited to share my PhD work in the Kranzusch Lab published in @nature.com! Two key discoveries: - Nucleotides can act as negative regulators of antiviral immunity - Ion channel activation is gated by DNA Thank you to our all collaborators! @soreklab.bsky.social www.nature.com/articles/s41...

Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!

We have a new article out in collaboration with the group of Michiel Vermeulen at @nkinl.bsky.social Photoaffinity probes based on olaparib for Proteomics profiling. Simple but powerful 💪 Read here: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Interesting paper by the groups of Dima Filippov @leidenadpr.bsky.social @led3hub.bsky.social and @michielvermeulen.bsky.social in ChemBioChem. They developed a biotinylated photoaffinity probe of the PARP inhibitor Olaparib and used it to profile off-targets. chemistry-europe.onl...

Celebrating 14 years of science, teamwork, and resilience! To mark our lab’s anniversary, we traded pipettes for pottery—turns out shaping clay is just as therapeutic as shaping experiments. With NIH funding uncertainties, a little calm goes a long way. Grateful for this team! #LabLife

Check out our approach toward disciformycin and gulmirecin, spearheaded by Peter Ruehmann @nyuchemistry. pubs.acs.org/doi/10.1021/...

💯 👇

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

Excited to share our new review on biomolecular condensates mediated by PARPs and ADP-ribosylation @ Trends in Biochemical Sciences! Despite the uncertainty, science must march forward. Grateful for the support that makes discovery possible. #FundScience #KeepScienceStrong

We have a new article out in collaboration with the group of Michiel Vermeulen at @nkinl.bsky.social Photoaffinity probes based on olaparib for Proteomics profiling. Simple but powerful 💪 Read here: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Nice work from the Andexer laboratory on PPK2 enzymes and their use in nucleotide synthesis doi.org/10.1002/cbic...

great new insights from Ji Luo, Barry O´Keefe and Brice Wilson on ITPK1 inhibitors www.sciencedirect.com/science/arti...

It is that time of year again... our Christmas tree arriving today! 🎄 (photos of the fully decorated tree to follow!)

Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨ pubs.acs.org/doi/10.1021/...

Interesting paper by the @roelfesgroup.bsky.social and the group of Daniel Sauer in @angewandtechemie.bsky.social. They used genetic code expansion to incorporate a thiophenol-containing amino acid into a protein and used it to make an artificial gold enzyme. onlinelibrary.wiley.com/doi/10.1002/...

Interesting workshop organized by the Young Academy Leiden about public outreach including through publishing news articles for the general public e.g. with @uk.theconversation.com. Great insights, how to pitch an idea to a publisher. Thank you Mike Herd for the presentation. www.theconversation.com

Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut https://www.biorxiv.org/content/10.1101/2024.11.27.625627v1

It is great to have @aekiib.bsky.social from the group of @tbpoulsen.bsky.social as visiting PhD student in the lab. His stay in our lab allows us to exchange a lot of thoughts and technologies between the labs and learn so much from each other. #ChemBio onlinelibrary.wiley....

'Skeetorial' of our latest paper: link.springer.com/article/10.1... So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social. (1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.

Amazing to see, how this platform is growing. This post is only 9 days old and my number of followers has tripled since then to over 1500. Very excited that we have an active scientific community on this platform again. Follow me for updates on the scientific literature with a focus on #ChemBio.

Excellent study demonstrating that chronically low NMNAT2 levels in neurons leads to NMN-induced SARM1 activation and subsequent axon degeneration. Their findings provide critical insight into the pathogenesis of partial loss-of-function mutations in NMNAT2 in humans with early-onset neuropathy.

This is such a cool and unexpected story.

Amazing talk by Thanja Lamberts at the #ReedijkSymposium. She talked about her work in the field of astrochemistry and the importance of surface chemistry, low temperature, low density, element availability, timescales and telescopes for her research. pubs.acs.org/doi/10.1021/...

Illuminating talk by Zach Armstrong at #ReedijkSymposium in Leiden. Cryo-EM on human fucosidase doi.org/10.1016/j.st... and more fascinating glycoscience

Thanks to Arturo Carabias and Guillermo Montoya for the beautiful review of our discovery and especially for the very nice and clear summary figure - I will use it a lot😀

Andrey Klymchenko also gave an interesting overview of their efforts to use dynamic covalent chemistry to address probes and photodynamic therapy agents to different cellular compartments. (2/2) pubs.rsc.org/en/content/a...

A new take from the Corbett lab on ubiquitin-like proteins in bacterial immune systems - oligomerization is mediated by calcium ions. Reminiscent of calcium-mediated immune signaling in human? Interesting.

Finally moved to #Bluesky and happy to share our recent work about a new phage anti-defense system, based on NAD reconstitution by new enzymatic reactions. www.nature.com/articles/s41...

Marcellus Ubbink opens the #ReedijkSymposium of the Leiden Institute of Chemistry. Great to see him highlight the achievements of the institute in the last year and excited that the namesake of the symposium, Jan Reedijk, is also personally present.

It was a great pleasure to present our group's work at the #ReedijkSymposium of the Leiden Institute of Chemistry in front of a full house. Excited that I was able to present some of the exciting new work that is going on in the group for the first time. chemrxiv.org/engage/chemr...

Today the Leiden Institute of Chemistry is having its #ReedijkSymposium. We are glad that @led3hub.bsky.social is well represented with talks by Sebastian Geibel, @stephanhacker2.bsky.social and Zach Armstrong as well as by posters by many PhDs and postdocs. www.universiteitleiden.nl/en/events/20...

I don't think it is the weirdest... lactylation? RNAylation? Hypusinylation? Dipthimidylation?

interested in all things Parp and ADP-ribosylation? arguably the weirdest posttranslational modification EVER? here is a starter pack, compiled by @leunglab.bsky.social go.bsky.app/CiRKAXJ

Should add that they showed that the other polymerases in the PARP family-PARP2 and tankyrases-also generate free PAR.

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...

This looks like an interesting application of the oxSTEF probes developed in the Poulsen lab before. Good example of developing interesting chemistry/chemical biology and then asking the right biological questions.

Intriguing new paper by @mflangelier.bsky.social in the Pascal lab showing that PARP1 can generate free poly-ADP-ribose (PAR) (not attached to proteins) in vitro and in cells. In some cases PAR is attached to NAD+! #PARP #ADP-ribosylation #NAD+ www.cell.com/molecular-ce...

Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...

Amazing compilations for everyone to join this new sky!!

Zach Armstrong of the @led3hub.bsky.social today gave a talk at the new Leiden Seminars in Biophysics and Structural Biology of @unileiden.bsky.social. He talked about studying human fucosidase and heparanase with chemical and structural biology methods.

Great talk by Zach Armstrong of @led3hub.bsky.social at the new Leiden Seminars in Biophysics and Structural Biology (L(SB)2). He gave an exciting overview of his group's work on studying sugar-modifying enzymes with chemical and structural biology. pubs.acs.org/doi/full/10....