Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read! www.sciencedirect.com/science/arti...

This is terrifying. I am worried for the non-citizens who will be showing up to the science rallies this week. Please be smart. It’s unlikely institutions will be able to save you.

Are you an undergraduate student considering a career in academic research? Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications! Apply by 30th March. More info: www2.mrc-lmb.cam.ac.uk/students/stu...

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...

Criminalizing protest is a hallmark of authoritarian regimes

Not surprised…but bitterly disappointed all the same. Perhaps time for members to resign en masse. #RoyalSociety

Bought a while ago, only start reading now, seems timely!!! “French resistance by night, experiments (on lac operon) by day!!!”

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

This, by Jan Böhmermann is excellent: on Germany's persistent Nazis. Now, please, mein Herr, do America and its new Nazis in power. Gift link video: The Far Right is Rising in the Land of ‘Never Again’ www.nytimes.com/2025/02/20/o...

So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).

Every scientist should read this. Unbelievable, utterly insane, and outrageous. There is a significant fear that this could also reach Germany with the impending conservative-fascist government (CDU/NSAfD), which Germany is highly likely to have by early summer.

DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines. https://go.nature.com/4hxoRGD

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

Friedrich Merz, the leader of the German CDU, just claimed in parliament that gang rapes are committed on a daily basis by asylum seekers in Germany. It is pure far right propaganda. The mainstreaming of the far right is happening on steroids in Germany right now.

We’ve updated the #AlphaFold 3 code, see below for details!

Researchers used AlphaFold alone (no wet-lab experiments; no cryo-EM etc.) to build a structural model and predict how a huge complex in cells, made of 17 proteins, spans across the bacterial cell envelope to transduce force for motility. Can anyone tell me if this is a first?

Too many AI projects begin at the wrong starting point. They start with an existing dataset, and ask “what can we do with this data?” The harder question is, “what are the biggest questions in your area, and what data would be useful to answering them?” 5/

🇭🇳 Contribute to the community 🇮🇪 Publish papers, but also be publicly visible 🇺🇸 Publication record, impact, and research quality This is how to become a professor where you are https://go.nature.com/3WpESGE

Genome-wide absolute quantification of chromatin looping https://www.biorxiv.org/content/10.1101/2025.01.13.632736v1

Mechanisms of chromatin remodeling by a Snf2-type ATPase https://www.biorxiv.org/content/10.1101/2024.12.31.630910v1

Differential effect of supercoiling on bacterial transcription in topological domains https://www.biorxiv.org/content/10.1101/2025.01.02.631060v1

If your new year resolution is doing a PhD, there is still time left to apply for a project in my group looking at how the condensin complex undergoes such large conformational changes while making loops. I mean look at how cool the starting model is:

"I began to see my time off not as a failure, but as a necessary pause." #ScienceWorkingLife scim.ag/3PxSewJ

Woah, this has so many potential applications! www.nature.com/articles/s41...

"You'll be revisited by three spirits" The spirits:

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes! Contact me at [email protected] For details on how to apply: www.findaphd.com/phds/project...

I eventually managed to try out Google's NotebookLM. Mind blown! 🤯 Recommendation: Try it out with one of your recent papers. Let me just share this podcast about the Hitchhiker's Guide to Bio-Image Analysis Software from 2022🔬🖥️🤓🔈 notebooklm.google.com/notebook/707...

It's awesome that most of the coauthors are on Bluesky! 🤩 I had so much fun learning, collaborating with @amardeeep.bsky.social from @kevincorbett.bsky.social lab. Thanks to @jessicakoenig.bsky.social and Martin Baaske from @eugenekimlab.bsky.social