One of the great mysteries I have pondered in science is given that they're clearly are not enough faculty jobs why are there people who have labs at multiple institutions? And this is not directed at any one person. Just seems like a real wild thing.

#Molecular grammars of predicted intrinsically disordered regions that span the human #proteome: Cell www.cell.com/cell/fulltex...

For everyone going to #SfN in San Diego

Breaking news: House Democrats release Epstein emails alleging President Trump knew of activities, including one claiming the president had “spent hours” at Epstein’s house with one of his sex trafficking victims.

Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41... #blueprint 1/7

QM formalized without imaginary numbers! www.quantamagazine.org/physicists-t...

arXiv is taking steps to tackle a surge in low quality, AI-generated content go.nature.com/4oRkjyq

A Perspective in Nature discusses how recent studies integrating multi-omics data with cell atlases across development for brains of humans and model organisms are revealing conserved and divergent patterns of brain development at the molecular and cellular levels. 🧪

Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait? Wrong. Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...

A film you've seen more than seven times with a gif

The amount of postdocs who I personally know that are looking to leave the U.S. is increasing dramatically...

Come work with me! @jhubiostat.bsky.social is hiring for a tenure-track Assistant Professor position 🥳 Apps due Nov 15 🔗 apply.interfolio.com/176686 🧪🧬💻🧠 #StatsSky #WomenInSTEM

Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab. (1/2) www.sciencedirect.com/science/arti...

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @pku1898.bsky.social go.nature.com/47yENVJ

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

Going deeper into digital image processing. If you have any great resources, please reply! I'm coming from the -omics field, so I have a data science background, but not signal processing. Lots to learn!

Talk about an in-flight meal. For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: https://scim.ag/3Jqldmn

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social

Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes www.science.org/doi/10.1126/...

Wikipedia is one of the great successes of the internet, maybe its greatest. That folks are dedicating themselves to tuning it into a partisan thing, just like everything else, is so frustrating.

Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development. doi.org/10.1016/j.cd...

Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...

Wow. Harvard nuking its PhD programs - Science PhD admissions reduced by more than 75% - Arts & Humanities reduced by about 60% - Social Sciences by 50–70% - History by 60% - Biology by 75% - The German department will lose all PhD seats - Sociology from six PhD students to zero

Excited to share another #opensource tool from the lab! We have been using this set up to do awake head-fixed scans without the need for any anesthesia on the day of the scans! Now working on integrating licking behaviour and linear treadmill operandum!

What if the DNA methylation enzyme DNMT1 isn’t just about DNA? Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking. A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

BREAKING: new racist Republican groupchat has been leaked to Politico featuring texts from Paul Ingrassia, Trump’s nominee to lead the Office of Special Counsel. Ingrassia’s texts include vile pro-Nazi & racist messages targeting Black people, Chinese people, and Indian people.

What is it about chicken noodle soup that feels so good when you're sick?

Set to run for 25 years, the effort will produce multiomic maps not just for monkeys but for developing, adult, aging, and diseased human brains from diverse populations. https://scim.ag/4o44CDP

Smdh...

Correction for multiple comparisons should be ubiquitous www.nature.com/articles/s41... 👍👏

So no terrorism then?

Left lab early to get more work done at home, but it looks like everyone had the same idea... So much damn traffic today!

An imaging method embeds tissues in a light-sensitive hydrogel and then uses light to degrade a tissue layer between each imaging cycle, allowing mesoscale fluorescence imaging at nanoscale resolution #NBThighlight www.science.org/doi/10.1126/...

Differential #synaptic #depression mediates the therapeutic effect of deep #brain stimulation www.nature.com/articles/s41...

Differential synaptic depression mediates the therapeutic effect of DBS www.nature.com/articles/s41...

This is a historic moment for our country. In a bad way. This tells the world that the U.S. is in a lot of trouble...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...

Just ordered a portable ssd drive for my personal laptop after experiencing the reason you always need backups.

“The Defense Department has confiscated the badges of the Pentagon reporters from virtually every major media organization in America,” the Pentagon Press Association said

Shown this one before over the years at the old site, but once again for Bsky, CT scan images through a live pumpkin scanned at 600 micron thickness, w/ lots of post processing, video flythrough, etc. The detail is exquisite. Best seen not on a phone. (🔖 it) randomfootage.homestead.com/pumpkin.html

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

Congratulations to Rebekah Rashford and team, it’s finally out! We tagged early life stress-activated neurons in VTA and found that chromatin those cells was much more open, even into adulthood, and that open CREs predicted greater gene expression in response to stress later in life rdcu.be/eLa9z

#Pterosaur died with belly full of plants—a #fossil first | Science | AAAS www.science.org/content/arti...

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Just saw a red tailed hawk swoop right over my head and caught a pigeon!

Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10

My two cents on that AI tool to format papers: I do not think anyone should be using AI to format anything but, most importantly, the website doesn't show who owns it or how it is done and it says "hehe we pwomise we won't store your dwata hehe". Do with that what you may 🧪

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com