We’ve mapped the Achilles tendon at single-cell resolution 🧬 — revealing 6 fibroblast types with distinct roles across muscle–tendon zones. A new atlas for understanding injury + repair. Find our more in our new preprint www.biorxiv.org/content/10.1... #Tendon #CellAtlas #SpatialTranscriptomics

Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.

Dr Sarah Snelling @sarahsnelling.bsky.social is leading a new study aiming to develop a blood test that could identify markers of osteosarcoma. This could be game-changing for early detection of this disease.

Annemarie’s latest paper is out today! CYR61 delivery promotes angiogenesis during bone fracture repair. www.nature.com/articles/s41... @amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.

Fibroblasts & endothelial cells appear to orchestrate the early response to injury in ruptured quads tendons. Great to see this published in & congratulations to @joletmimpen.bsky.social & the rest of the team. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Join us online for the @humancellatlas.bsky.social Musculoskeletal Bionetwork seminar on 21st May at 4pm GMT. We're excited to hear about spatial mechano-transcriptomics from Dr Adrien Hallou @halloulab.bsky.social Open to all interested in MSK atlases in any species! Register now bit.ly/4jhakA8

Ever torn a tendon? Our study led by @joletmimpen.bsky.social discovered changes in fibroblast and immune cell populations that occur in quadriceps tendon tears. Read more: doi.org/10.1113/JP28... @sarahsnelling.bsky.social @adamcribbs.bsky.social

Calling clinicians, research nurses, lab scientists & bioinformaticians! Please fill out our short survey on challenges & enablers for #biobanks & #Omics research. Respondents from #GlobalSouth & #LMICs especially welcome! @ndorms.bsky.social @humancellatlas.org bit.ly/41nHHex

Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social www.cell.com/cell/fulltex...

This is very cool! www.nature.com/articles/s41...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻 #macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social www.biorxiv.org/content/10.1...

It had to be done! I do love tendons, but other musculoskeletal tissues including synovium should get a bigger mention here - let's see what the next few years bring!

I cannot think of anyone more deserving than Megan Killian (@megankillian.bsky.social) for the Community Council Chair on the ORS Board of Directors ballot 😍 Megan is one of those rare gems who goes above and beyond in making folks feel included and heard. A fantastic human being 👇 t.co/h60xhz38NN

If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you! boneandjoint.org.uk/Article/10.1...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation! We can teach it all off 1 paper! 1. Woo 2. Hoooo!!! H/t @lianafaye.bsky.social www.biorxiv.org/content/10.1...

Thinking of doing a DPhil/PhD? Then take a look at this! www.ndorms.ox.ac.uk/news/blog/st... The brilliant @joletmimpen.bsky.social & 2 of our fab students @ndorms.bsky.social discuss PhD & post-PhD life in an interdisciplinary team. From my perspective it's hugely fun & I'm always learning!

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

Fat tissue retains a ‘memory’ of obesity through cellular transcriptional and epigenetic changes that persist after weight loss, which might increase the chance of regaining weight, according to a study in Nature. go.nature.com/48ZTVfg

My first post on bsky☺️ The link to our review on #osteoarthritis recently published in Osteoarthritis and Cartilage www.oarsijournal.com/article/S106...

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)