This image of home just came down from the Artemis II crew. Taken after their translunar injection burn, there are aurorae at top right and lower left, and zodiacal light at lower right. Credit: NASA/Reid Wiseman

Excited to see our work out in Science today! Using machine learning to identify prokaryotic immune systems www.science.org/doi/10.1126/...

New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

Excited to share our lab's new paper in Current Biology featuring MS student Sydney Schultz's work. We show that a polar alga carries large amount of giant viral DNA in its genome, and many of the viral genes respond to stress - with implications for host adaptation. www.cell.com/current-biol...

Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Arabinose isn't only an inducer! @peterfineran.bsky.social gave a talk in our Hebrew Univ. microbiology journal club and mentioned his recent amazing finding that some phages add up to 3 arabinoses (!!) to their DNA to evade bacterial defense. Mahler et al. CHM 2025 www.cell.com/cell-host-mi...

Defining the chromatin-associated protein landscapes on <i>Trypanosoma brucei</i> repetitive elements using synthetic TALE proteins

Excellent new work on tRNA fragments in C. elegans supports my long-standing hypothesis that tRNA halves can serve as precursors for shorter fragments, rather than all tRNA-derived species arising directly from full-length tRNA through RNase T2 cleavage. doi.org/10.1038/s414...

1/11 🔥 New preprint alert 🔥 We wanted to know what plants in the wild really care about. So we asked them 🎤. Here is what we learned: “Biotic-response networks are an important organizer of the transcriptome in wild Arabidopsis thaliana populations” www.biorxiv.org/content/10.6...

One of the most-viewed PNAS articles in the last week is “From peptides to DNA: All required steps can be catalyzed.” Explore the article here: https://ow.ly/Pa4q50YrSfY For more trending articles, visit https://ow.ly/jUm050YrSg0.

Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression www.nature.com/articles/s41... Coronaviruses reprogram our cells – a new drug could target this vulnerability. smartup-news.de/gesundheit/h...

Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...

Spligation enables programmable chimeric RNA generation in living cells doi.org/10.64898/202...

Happy to share our new preprint on the mechanism of human tRNA 3' CCA maturation! This project was spearheaded by Bernhard Kuhle in my group, with contributions from many others and a great collaboration with the group of Peter Rehling (UMG). See highlights below! www.biorxiv.org/content/10.6...

New preprint from @novoalab.bsky.social ! Which tRNAs are used by ribosomes during translation? We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions. www.biorxiv.org/content/10.6... Thread 👇

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

1/5 Happy by a recent biorxiv pre-print about DARNA (PD-T7-3) anti-phage defense system. This system is activated by binding to ssDNA, presented by phage SSB, to cleave tRNA in the anti-codon loop. www.biorxiv.org/content/10.6...

Kumari’s interest in plant science began with a fascination for how plants adapt and thrive in diverse environments. academic.oup.com/plcell/artic... #WeAreASPB

1/6) Hot off the press @natsmb.nature.com 🔥! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage 🛡️. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication 🦠🚫. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH

New preprint on Detectrons from @jihoon-han.bsky.social! These are programmable biosensors for RNA that produce DNA barcodes in the presence of their target RNA. Check out Jihoon's quoted thread and the preprint for more: www.biorxiv.org/content/10.6...

Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX

𝗛𝗮𝗽𝗽𝘆 𝗖𝗵𝗶𝗻𝗲𝘀𝗲 𝗡𝗲𝘄 𝗬𝗲𝗮𝗿 𝘁𝗼 𝗮𝗹𝗹 𝗳𝗿𝗶𝗲𝗻𝗱𝘀, 𝗰𝗼𝗹𝗹𝗲𝗮𝗴𝘂𝗲𝘀, 𝗮𝗻𝗱 𝘁𝗲𝗮𝗰𝗵𝗲𝗿𝘀🧧🐎🐴✨ 🎉🎊 Wishing you a Spring Festival filled with joy 🤩🥟 and a New Year full of energy 🌱☀️. May the Year of the Horse 🐎 bring you strength 💪, speed ⚡, and success 🏆 in all your endeavours 😇 #ChineseNewYear2026 #ChineseSpringFestival

How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...

#microsky #glycotime #sialic acid www.tandfonline.com/doi/full/10....

Extremely proud to see Priyanka Kumari, PhD student in Chang Liu’s lab and co-first author on my postdoctoral work, featured in Plantae! 👇 @plantaeofficial.bsky.social plantae.org/the_plant_ce...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

1/9 Our latest paper on immunity mechanisms in Marchantia just out @pnas.org ! 🔽 Close collaboration between our former PhD students @karimaelm.bsky.social and @chloe-beaulieu.bsky.social ! and the old gard @jacquet-chris.bsky.social @maximebonhomme.bsky.social www.pnas.org/doi/10.1073/...

4 - Still lots to learn about this mysterious factor. 🔗 Read the paper: academic.oup.com/nar/article/... Funded by @dfg.de via SFB TRR319-RMaP 🙏 #RibosomeBiology #TranslationQC #RNA #Nanopore #Yeast #PhDPosition #DFG #RMaP #New1

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

📢 Rfam 15.1 is here! ✨ 50 new RNA families including riboswitch candidates, plastid ncRNAs, snoRNAs, plant xrRNAs and more. 🧬 10 families updated with 3D structures 🖥️ Brand new interactive alignment viewer Take a look xfam.wordpress.com/2026/01/08/r... #RNA #Bioinformatics #RNAbiology

Active transport of tRNAs facilitates distributed protein synthesis https://www.biorxiv.org/content/10.64898/2026.01.26.698744v1

Interesting that a 𝘥𝘦𝘧𝘦𝘯𝘴𝘦𝘭𝘦𝘴𝘴 mutant (𝘢𝘣𝘪𝟣-𝟣 𝘤𝘰𝘪𝟣 𝘦𝘥𝘴𝟣 𝘦𝘪𝘯𝟤 𝘳𝘣𝘰𝘩𝘋 𝘴𝘪𝘥𝟤) is less sensitive to fungal infection than a 𝘤𝘺𝘣𝟩𝟫𝘣𝟤/𝘣𝟤 mutant (Similarly, 𝘦𝘥𝘴𝟣 𝘴𝘪𝘥𝟤 is more susceptible to bacterial infection than the 𝘥𝘦𝘧𝘦𝘯𝘴𝘦𝘭𝘦𝘴𝘴). From @newphyt.bsky.social: shorturl.at/jYbOS #PlantScience #PlantImmunity

Another piece of the microbe-mucin interactions puzzle 🧩: Enzyme extracts of our favourite mucin glycan degraders cleave different bonds that occur in mucins. 🍬 Expression of glycoside hydrolases also differs per species. ✂️ To each their own! 😋 #glycotime #microsky #mucin doi.org/10.1093/glyc...

🚀 New preprint! @jacobsenucla.bsky.social x @doudna-lab.bsky.social collaboration: High-activity TnpB (Ymu1-WFR) + a multi-gRNA system in TRV enables heritable, tissue-culture-free multiplex editing in plants. Big potential for plant biotech 🧬🌾🌱 doi.org/10.64898/202...

Programmable protein editing by split intein-mediated recombination by Takumi Yanase and team: www.biorxiv.org/content/10.6...

Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...

On ne peut progresser sans se tromper. Comment dès lors inviter les étudiants à ne plus craindre l’erreur mais à la voir comme une opportunité d’acquérir de nouvelles compétences ? Exemple à travers un dispositif d’apprentissage par l’action.

New Brief Communication: "A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins" rdcu.be/eZLUP CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .

Enhancing apple disease resistance using magnetic nanoparticles carrying artificial miRNAs that suppress a tRNA-derived small RNA targeting a disease-resistant gene #research #PlantCommunications cell.com/plant-commun...

Our new article is now online on @natplants.nature.com! ✨ We identified and characterised AvrPm4 and SvrPm4, a pair of powdery mildew effectors controlling avirulence on the wheat kinase fusion resistance protein Pm4 🌾 check it out ➡️ www.nature.com/articles/s41...

New preprint 👉Doudna x Bryant x Jacobsen x Savage collaboration! Work led by @zehanzhou.bsky.social, I. Saffarian-Deemyad, @honglue.bsky.social, T. Weiss We dissect how stepwise DNA unwinding gates TnpB genome editing, revealing how unwound DNA states enhance cleavage www.biorxiv.org/content/10.6...

A (belated!) highlight from an excellent collaboration with @dunhamlab.bsky.social and #HouLabTJU. In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.

very unusual - a tRNA regulated anion channel

✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇

Phages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out tinyurl.com/bdcfrejh

Ethylene modulates cell wall mechanics for root responses to compaction www.nature.com/articles/s41...