Finally out 🎉 New paper in Nature Chemical Biology! Using RF-diffusion, we designed protein inhibitors that bind the CRISPR Cas13a active site, something very hard to find in nature. Thanks to everyone involved for the hard work! 👏 www.nature.com/articles/s41...

Big news! 🎉 The CRISPR Down Under 2026 speaker line-up is out. Join us in Melbourne (24–25 Mar) for two days of exciting CRISPR science, great talks & great people ! Early-bird & abstracts close 30 Jan ! 🔗 crispr.org.au

CRISPR Down Under 2026 is here! 📍 Melbourne | 📅 Mar 24–25 2026 Early-bird ends Jan 30! Register & Abstracts : crispr.org.au Join us for cutting-edge CRISPR research! #CRISPR #MelbourneEvents

Big milestone for the AI Protein Design Program last November: our first AI binder design workshop! Proud of the team and grateful to @kmichie.bsky.social for her amazing talk. This is just the beginning… excited for what’s next! #AI #ProteinDesign #AIPDP

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead ! www.cell.com/structure/fu...

Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :) I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors 12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c... #CryoEM #Membranes

ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!

Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco

An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots https://go.nature.com/3ZaM0rD

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.

New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology! www.biorxiv.org/content/10.1...

Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025

Petit reportage de France Inter sur notre utilisation de l'IA au labo: - Combiner prédictions informatiques et validations expérimentales - Un nouveau monde à explorer - Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers. www.radiofrance.fr/franceinter/...

Scaling data analyses in cellular cryoET using comprehensive segmentation [new] Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

After a decade in the oven🧑‍🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base. 📜 https://dir.lat/41qAY4 We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy! Check out the preprint: www.biorxiv.org/content/10.1... Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com #TeamTomo

Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr

Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year! www.lorneproteins.org

A postdoctoral position is available in our team to study the type VI secretion system. Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team Reposts appreciated 😊

This is such a cool initiative! DL4Proteins is democratizing deep learning for protein design and prediction at a pivotal time in science—a fantastic step toward making advanced protein engineering accessible to all! github.com/Graylab/DL4P...

1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM. www.youtube.com/playlist?lis...

To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful! www.biorxiv.org/content/10.1...

Moins de réseaux sociaux, moins de télé : pour beaucoup, réduire le flux d’informations est devenu une nécessité, et certains choisissent même de TOUT éteindre. ➡️ l.franceculture.fr/ktX

Excited to share my first-author preprint from the Knott Lab! Using de novo protein design, we developed anti-CRISPRs to potently inhibit CRISPR-Cas13. Thanks to my amazing co-authors ! www.biorxiv.org/content/10.1... #CRISPR

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

CRISPR, via Peter Fineran at the other place - 📢 Calling all Early Career Researchers! 🌟 Apply now for travel grants to attend the CRISPR 2025 Conference in Christchurch, New Zealand 🇳🇿 💰 Up to US$500 for travel/accommodation Deadline: Dec 6, 2024 🗓️ 👉 crispr2025.org/grant