Chris Jackson
@cajackson.org
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📥 1963
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Systems biology
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Chris Jackson
Micah McCurdy
7 days ago
Would like to dedicate this post to the people who yelled at me for giving the Sabres 58% to make the playoffs in my season preview this past summer.
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geoffrey
8 days ago
yes. they pay more based on income in taxes for the thing that is then “free” for everyone. this is how public services work
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David A Knowles
9 days ago
@nygenome.org
is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at:
jobs.silkroad.com/NYGenome/Car...
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NYGC Genomic AI Fellows - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center
Find a career with New York Genome Center
https://jobs.silkroad.com/NYGenome/Careers/Jobs/779
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Chanda Prescod-Weinstein 🌌
10 days ago
If all goes according to plan, in a few hours, a crew of astronauts will begin a journey that will take them on a loop around the moon. Here's a video that NASA put together to help people visualize the journey through space, first orbiting the earth before looping around the moon and flying home 🔭
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Danielle Navarro
11 days ago
this is so stupid. you simply cannot do behavioural research this way. the core question here is how humans act in this situation and at the risk of having to explain a methodological point so basic it should never have to be said, you need humans for that
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Marisa Kabas
17 days ago
sorry i never responded to your email, i didn't want to and then i forgot
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Gillian Brockell
24 days ago
I just heard back from the reporter, and I am genuinely speechless. Is “we don’t care” the business model?
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Cameron Patrick
27 days ago
My motivation for perservering as a statistician even when it feels bleak comes from Ian Gordon: sometimes the best we can do is make sure that the research that gets done is better than it would have been if we weren't involved in it
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Ariel Levine
27 days ago
Check out the newest work from our, from Fabricio Nicola
@fabricionicola.bsky.social
on mouse jumping and spinal cell types. Excellent collab with
@vulcnethologist.bsky.social
www.biorxiv.org/content/10.6...
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Pretty much the same reason all the gene regulatory network inference models don't work as well as people think they do
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about 1 month ago
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Claus Wilke
about 1 month ago
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.08.710389v1
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Páll Melsted
about 1 month ago
Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv
www.biorxiv.org/content/10.6...
and github
github.com/pachterlab/k...
Figure 1 shows they key result
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K
about 1 month ago
sem condições esse daqui
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John Scalzi
about 1 month ago
I get asked to show up to book clubs, online and offline. Here is why from now on the answer is always "no." If you think this might have something to do with "AI" ruining yet another thing for everyone, you're absolutely 100% correct.
whatever.scalzi.com/2026/03/03/i...
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Indefinite Book Club Hiatus
Today in “Things that ‘AI’ has ruined”: No, I won’t be able to show up to your book club’s online/offline gathering, and the reason for this is simple: I, and li…
https://whatever.scalzi.com/2026/03/03/indefinite-book-club-hiatus/
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NY Times Pitchbot
about 1 month ago
Critics say that Trump's war with Iran could have a lot of blowback. But there is no historical precedent for the United States overthrowing an Iranian government and then facing 50 years of hostility from Iranians.
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Jonathan Eisen
about 1 month ago
Crap
www.online-tribute.com/DavidBotstein
David Botstein passed away. I worked with him at Stanford for a few years in designing and teaching a course on "The Heart". My heart is heavy right now. He was a wonderful mentor.
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David Botstein | 1942 - 2026 | Online-Tribute.com
David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…
https://www.online-tribute.com/DavidBotstein
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Brooke Foster
about 1 month ago
crying in the club* (*at my desk) bc stanley tucci took the USA women's hockey team out for a meal at his favorite restaurant and they gave him his own jersey
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Micah
about 2 months ago
they need to import this to the Stanley Cup playoffs, watching hockey players be handed stuffed animals while they seethe is the new funniest thing in the world
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Olúfẹ́mi O. Táíwò
about 2 months ago
the only place this should happen is academic conferences
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Max Haase
about 2 months ago
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
https://www.nature.com/articles/s41586-025-10092-0
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Alex Merz 🇺🇸🇨🇦🇺🇦
about 2 months ago
🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered. This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red. 1/
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Seychelle Vos
2 months ago
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation.
tinyurl.com/CTCF-nucleos...
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penny
about 2 months ago
woke up and chose linguistics violence today: the word 'queue' is just the letter Q followed by four silent letters waiting in line behind it. they're literally queuing. this is the most honest word in the english language and i will not be taking questions at this time
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Franck Martin
2 months ago
I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration,
#ALS
#FTD
#Ribosomes
www.science.org/doi/10.1126/...
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Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxicity is thought to result from the accumulation...
https://www.science.org/doi/10.1126/science.adv2600
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David Zipper
2 months ago
Very cool paper measuring pedestrian volumes on NYC streets and examining crash risks: "Intersections with the highest pedestrian injury risk are often outside Manhattan, where exposure-adjusted danger is the greatest."
www.nature.com/articles/s44...
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Nick Ulivieri
2 months ago
The eastern shore of Lake Michigan - between South and Grand Haven - is loaded with mountain ranges of ice 😱
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All The Right Movies
2 months ago
BLAZING SADDLES was released 52 years ago today. Acclaimed as one of the great comedies of the 1970s, and among the most popular of director Mel Brooks, the story of how it was made is a cascading waterfall of creative alternatives... 1/36
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Jeremy Berg
2 months ago
A sad day at NIH... The NIH Record was a great way for NIH folks to find out what was going on across NIH. Many important stories published there over the years.
nihrecord.nih.gov/2026/01/30/n...
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NIH Record Ceases Publication
This will be the final issue of the NIH Record.
https://nihrecord.nih.gov/2026/01/30/nih-record-ceases-publication
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Chris Jackson
Vincent D. Warmerdam
2 months ago
seriously: I really enjoy using matplotlib now.
youtu.be/5ZxczGlrkyQ
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We made matplotlib interactive. You're welcome.
Our favourite plotting library may just be matplotlib again now that we made it interactive with a puck! It may sounds strange at first, but pucks turn these...
https://www.youtube.com/watch?v=5ZxczGlrkyQ
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Chris Jackson
Jeremy Berg
3 months ago
My (now) weekly update on 2026 NIH funding. New and competitive renewal awards. 3 new awards (compared to ~100 expected based on recent years). No new ICs... still just NIA, NINDS, NIDCD, and NIDCR. 1/2
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Kevin M. Kruse
3 months ago
Holy hell, what an obituary
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Renfrew Christie Dies at 76; Sabotaged Racist Regime’s Nuclear Program
https://www.nytimes.com/2026/01/14/world/africa/renfrew-christie-dead.html?unlocked_article_code=1.ElA.l_uO.quxTSV0lHbGV&smid=url-share
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Tomer Ullman
3 months ago
once again being driven insane by ML conference submissions
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Michelle Girardi
3 months ago
Excited to share this with
#BlueAndGoldSky
Hasek took us back to the rink he grew up on in Pardubice, Czechoslovakia and introduced us to the people who had the greatest influence on his young life.
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Governor Kathy Hochul
3 months ago
Universal child care is coming to New York.
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Altmetric
3 months ago
THREAD The first full year of tracking research on
@bsky.app
Hi, we are Altmetric, and we track how research is communicated across the web. We now have one full calendar year of Bluesky research data and thought we'd have a looksie.
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Dominique Baker
3 months ago
If you can't find research on bluesky, I do not know what to tell you
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Chris Jackson
Mark D. Levine
3 months ago
NY is having a bad flu season. More hospitalizations last week than any week on record. Health authorities are encouraging everyone aged 6mo+ to get the flu vax (it's not too late). Find a provider here:
on.nyc.gov/getvaccinated
. You can filter for sites where there's no cost for the uninsured.
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Stephen Turner
3 months ago
Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data
www.nature.com/articles/s41...
(free:
rdcu.be/dSsaH
) 🧬🖥️
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"You need AI skills to engineer a prompt" Is just "The random seed is another hyperparameter to tune" in a hat and trenchcoat
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4 months ago
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Chris Jackson
4 months ago
I just finished my 28th yr of teaching grad compbio. Following the inevitable trend, a 3rd of the course is now Deep Learning (DL). One activity we did was a deep dive into the AlphaGenome pre-print (
www.biorxiv.org/content/10.1...
). Question is, how do we evaluate it as a science paper? 1/n
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AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
Deep learning models that predict functional genomic measurements from DNA sequence are powerful tools for deciphering the genetic regulatory code. Existing methods trade off between input sequence le...
https://www.biorxiv.org/content/10.1101/2025.06.25.661532v2
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Julius Brennecke
4 months ago
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.
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I had a student explain that they were taught OLS (and knockoffs like ridge regression) were AI, in class, by her data science department 🤷♂️
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4 months ago
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Timnit Gebru
4 months ago
Wildly different things, tasks, techniques, subspecialties being lumped into "AI" and then being conflated with each other, doesn't help. Different types of models vs the techniques to train them vs the tasks they are supposed to accomplish, all under "AI".
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Jeanette
4 months ago
She expects us to believe that a university communicated anything of substance to an unsuccessful job candidate.
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Jake Berg
4 months ago
Gift link, probably the funniest thing the Wall Street Journal has done this year.
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We Let AI Run Our Office Vending Machine. It Lost Hundreds of Dollars.
An AI agent ran a snack operation in the WSJ newsroom. It gave away a free PlayStation, ordered a live fish—and taught us lessons about the future of AI.
https://www.wsj.com/tech/ai/anthropic-claude-ai-vending-machine-agent-b7e84e34?st=V2XjZM&reflink=desktopwebshare_permalink
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Ian Carrillo
4 months ago
"Changes to centers and institutes were initially projected to save $4.8 million." Bill Belichick's annual salary is $10 million.
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SE Gyges
4 months ago
everyone who uses an llm to code more than me is voluntarily deskilling themselves, everyone who uses it less than me might as well be hand-wiring together vacuum tubes
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Matthew Taliaferro
4 months ago
Excited to share that this work is now published in its final form!
link.springer.com/article/10.1...
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Jessica Tollkuhn
4 months ago
absolutely losing it at my 14yo's biology homework
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Sarah McAnulty, Ph.D.
4 months ago
Alright it's the 15th. 10 days to Christmas. Would someone in your life benefit from a calendar featuring animals??? We have 47 Love Notes From Nature calendars left. When they're gone, they're gone forever. Bonus? The proceeds fund our native plant project in Philly! Get one at
SquidFacts.net
!
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