Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵: www.cell.com/cell-genomic...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Bluesky, just here to say I appreciate you when things are otherwise no laughing matter

Big companies like Amazon, Meta, and Microsoft appear to be playing ball--issuing orders to their H1B visa employees last night, telling them to come back to the US by tomorrow.

Rasmus Dahlin has shared a letter with the community about his fiancee Carolina and a traumatic health episode she dealt with this summer and continues to battle www.nhl.com/sabres/news/...

🚨Our preprint is online!🚨 www.biorxiv.org/content/10.1... How do #dopamine neurons perform the key calculations in reinforcement #learning? Read on to find out more! 🧵

I'm willing to be on the chemistry job market if anyone needs a Suzuki reaction denier

this is a very good and incredibly sad piece about Canadian national treasure Robert Munsch, the author of phenomenal children's books Angela's Airplane, the Paper Bag Princess, Thomas's Snowsuit, and many others Munsch has dementia. Fuck dementia.

1. What does a Cold War-era game theory problem known as the silent duel have to do with high-risk research strategies, publication in Cell/Nature/Science glamor journals, and the academic job market? Kevin Gross and I tackle these questions in our latest arXiv preprint: arxiv.org/abs/2509.06718

Some personal news: I've been fired from the Washington Post in the aftermath of the Charlie Kirk shooting. Thread incoming. substack.com/@karenattiah...

I need everyone to know that there’s a guy in Toronto who white girl dances to Kesha & he now gets recognized in public. People are ELATED about joining and it is just the best thing.

A bluetorial on NIH funding and out year commitments: A historical perspective

New NIH Notice about International Collaborations grants.nih.gov/grants/guide... 1/3

HEAT PUMPS a decade ago, you pretty much had to heat your house with fossil fuel in upstate NY where I live now the electric powered heat pumps are so good they work down to minus 15F, and my heat bill is half what it used to be on propane this is a big piece of how we win on climate

La-Proteina from NVidia to do co-design of fully atomistic protein structures (sequence + side-chains + backbone) for up to 800 residues is now open source with permissive licensing 🖥️ github.com/NVIDIA-Digit... 🗎 arxiv.org/abs/2507.09466

Managers at the MTA's Subway Command Center shut down the subway at 10:20am on September 11, 2001. Halting subway service was first and foremost a safety decision. Almost immediately, crews began inspecting Lower Manhattan tunnels for bombs, and testing tracks with empty trains.

Whether it’s Republican politicians joking about the murder of Melissa Hortman or Democratic politicians expressing their condolences after the murder of Charlie Kirk, both parties have a extreme rhetoric problem.

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

A BLAST update adding support for compressed files and csv output with headers is a Good Friday night surprise! blast.ncbi.nlm.nih.gov/doc/blast-ne...

Thanks to everyone who spread the claim that "legal immigrants are fine" when that was so obviously not the case from the beginning

New York just got its first hybrid ferry, and it runs between Manhattan, Brooklyn, and Governors Island! The hybrid system works by using diesel-fueled generators to charge the onboard battery system, but eventually it won’t need the generators at all when a rapid charger is installed at the docks.

Current NY state law blocks pharmacies from dispensing vaccines (including the COVID vaccine) without a prescription, unless RFJ Jr.'s handpicked vaccine advisory council signs off. But state Sen. @bradhoylmansigal.bsky.social has proposed a bill to fix that: www.nysenate.gov/legislation/...

My son asked us why there was a bear at school and we were like WHAT?! A bear is not out of the question around here but it turns out he was talking about an active shooter drill. For the little kids they tell them there’s a bear and they have to be very quiet and hide against a wall.

remember folks, we cant have gun restrictions because if we do the federal government will occupy our streets, imprison people without due process, ship dissidents to foreign gulags and things of that nature

Clue 1 leads us to… John Lindsay East River Park!

the crisis in which the University of Chicago is now engulfed -- one entirely of its own making, and which has led to the (hopefully temporary) suspension of admissions into numerous PhD programs in the humanities -- represents I think a seismic event in the history of American higher education 1/

if you're not from or have never been to new york i cannot stress enough how normal the subway is 99% of the time. kids take it to school. everyone is basically chill. you learn to be in proximity with harmless weirdos or minor irritations pretty quick. for all its issues it's an incredible thing

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking. All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever. Yay for us!

The curse of chalion www.goodreads.com/book/show/61...

The latest eruption of Kilauea is underway, and she's shootin' sideways this time around! USGS live stream: www.youtube.com/watch?v=Bqmp...

Trying again: Does anyone know if the NSF GRFP will return this year? We're >1 month past the date of last year's solicitation (July 12, 2024) and there's not a new one up yet. @akallen10.bsky.social @surtlab.bsky.social @sicb.bsky.social @paleophile.bsky.social @omearabrian.bsky.social

1000 faculty hit the picket lines tomorrow, 930 am, lockout by @dalhousieu.bsky.social. A first for CDN research intensive universities. A reckless move by the Board - jeopardizing the fall term, ruining relations with faculty for years to come. Join us on the picket lines to #keepdalstrong!

My hot take is that if there is a single corporation so essential to national interests that the government allows its employees to exercise their Charter right to collective bargaining for 10 minutes before calling it illegal, then that company should be broken up.

If you're still clinging on to the hope that the NIH will somehow return to normal in FY26, I just don't know what to say to you at this point.

No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:

Assault with a breadly weapon… 🥪

NYC is a major economic engine. We are a leading indicator for the nat’l economy. Data just out shows job growth here in 1st half of 2025 has come to a screeching halt. Tariffs, decline of int’l visitors, and economic uncertainty are hitting us hard. This should be a warning for the country.

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

civilization vi leader two turns before you destroy his lone attacking trebuchet unit with a missile cruiser

Just to give the TL;DR on this one: *The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.

I don’t know why this incenses me as much as it does, but it does: we very likely have a thousand plus Mozarts *right now*. But they make non-Western art in economically destitute conditions so they have to do other work to pay bills; if you cared, UBI’d be more important to you than going to space

The US could see a 30-40% decline in new international student enrollment, resulting in nearly $7 billion in lost revenue and more than 60,000 fewer American jobs. https://www.nafsa.org/fall-2025-international-student-enrollment-outlook-and-economic-impact

Oh no do I need to make a thread about how hilarious it is that they’ve decided to freak out about Shia Muslims specifically

"The man who is not yet mayor is to blame for a shooting that happened under the watch of an ex-cop mayor who's thrown every available dollar at the NYPD," insists sex pest

I love having the opportunity to post this video: youtu.be/HkalBd1xKWI?...

Most reporting is just not up to the task of registering both that 1) the White House is *attacking* universities *as institutions* 2) the White House is working *with* universities’ boards to achieve *common goals* for remaking and weakening those institutions