Would like to dedicate this post to the people who yelled at me for giving the Sabres 58% to make the playoffs in my season preview this past summer.

yes. they pay more based on income in taxes for the thing that is then “free” for everyone. this is how public services work

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

If all goes according to plan, in a few hours, a crew of astronauts will begin a journey that will take them on a loop around the moon. Here's a video that NASA put together to help people visualize the journey through space, first orbiting the earth before looping around the moon and flying home 🔭

this is so stupid. you simply cannot do behavioural research this way. the core question here is how humans act in this situation and at the risk of having to explain a methodological point so basic it should never have to be said, you need humans for that

sorry i never responded to your email, i didn't want to and then i forgot

I just heard back from the reporter, and I am genuinely speechless. Is “we don’t care” the business model?

My motivation for perservering as a statistician even when it feels bleak comes from Ian Gordon: sometimes the best we can do is make sure that the research that gets done is better than it would have been if we weren't involved in it

Check out the newest work from our, from Fabricio Nicola @fabricionicola.bsky.social on mouse jumping and spinal cell types. Excellent collab with @vulcnethologist.bsky.social www.biorxiv.org/content/10.6...

Pretty much the same reason all the gene regulatory network inference models don't work as well as people think they do

New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

sem condições esse daqui

I get asked to show up to book clubs, online and offline. Here is why from now on the answer is always "no." If you think this might have something to do with "AI" ruining yet another thing for everyone, you're absolutely 100% correct. whatever.scalzi.com/2026/03/03/i...

Critics say that Trump's war with Iran could have a lot of blowback. But there is no historical precedent for the United States overthrowing an Iranian government and then facing 50 years of hostility from Iranians.

Crap www.online-tribute.com/DavidBotstein David Botstein passed away. I worked with him at Stanford for a few years in designing and teaching a course on "The Heart". My heart is heavy right now. He was a wonderful mentor.

crying in the club* (*at my desk) bc stanley tucci took the USA women's hockey team out for a meal at his favorite restaurant and they gave him his own jersey

they need to import this to the Stanley Cup playoffs, watching hockey players be handed stuffed animals while they seethe is the new funniest thing in the world

the only place this should happen is academic conferences

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered. This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red. 1/

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

woke up and chose linguistics violence today: the word 'queue' is just the letter Q followed by four silent letters waiting in line behind it. they're literally queuing. this is the most honest word in the english language and i will not be taking questions at this time

I'm thrilled to anounce that our latest study on ALS/FTD neurodegenerative diseases has been published. Very proud to be part of this excting project. Many thanks to Clotilde Lagier Tourenne for an amazing longlasting and fruitfull collaboration, #ALS #FTD #Ribosomes www.science.org/doi/10.1126/...

Very cool paper measuring pedestrian volumes on NYC streets and examining crash risks: "Intersections with the highest pedestrian injury risk are often outside Manhattan, where exposure-adjusted danger is the greatest." www.nature.com/articles/s44...

The eastern shore of Lake Michigan - between South and Grand Haven - is loaded with mountain ranges of ice 😱

BLAZING SADDLES was released 52 years ago today. Acclaimed as one of the great comedies of the 1970s, and among the most popular of director Mel Brooks, the story of how it was made is a cascading waterfall of creative alternatives... 1/36

A sad day at NIH... The NIH Record was a great way for NIH folks to find out what was going on across NIH. Many important stories published there over the years. nihrecord.nih.gov/2026/01/30/n...

seriously: I really enjoy using matplotlib now. youtu.be/5ZxczGlrkyQ

My (now) weekly update on 2026 NIH funding. New and competitive renewal awards. 3 new awards (compared to ~100 expected based on recent years). No new ICs... still just NIA, NINDS, NIDCD, and NIDCR. 1/2

Holy hell, what an obituary

once again being driven insane by ML conference submissions

Excited to share this with #BlueAndGoldSky Hasek took us back to the rink he grew up on in Pardubice, Czechoslovakia and introduced us to the people who had the greatest influence on his young life.

Universal child care is coming to New York.

THREAD The first full year of tracking research on @bsky.app Hi, we are Altmetric, and we track how research is communicated across the web. We now have one full calendar year of Bluesky research data and thought we'd have a looksie.

If you can't find research on bluesky, I do not know what to tell you

NY is having a bad flu season. More hospitalizations last week than any week on record. Health authorities are encouraging everyone aged 6mo+ to get the flu vax (it's not too late). Find a provider here: on.nyc.gov/getvaccinated. You can filter for sites where there's no cost for the uninsured.

Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data www.nature.com/articles/s41... (free: rdcu.be/dSsaH) 🧬🖥️

"You need AI skills to engineer a prompt" Is just "The random seed is another hyperparameter to tune" in a hat and trenchcoat

I just finished my 28th yr of teaching grad compbio. Following the inevitable trend, a 3rd of the course is now Deep Learning (DL). One activity we did was a deep dive into the AlphaGenome pre-print (www.biorxiv.org/content/10.1...). Question is, how do we evaluate it as a science paper? 1/n

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

I had a student explain that they were taught OLS (and knockoffs like ridge regression) were AI, in class, by her data science department 🤷‍♂️

Wildly different things, tasks, techniques, subspecialties being lumped into "AI" and then being conflated with each other, doesn't help. Different types of models vs the techniques to train them vs the tasks they are supposed to accomplish, all under "AI".

She expects us to believe that a university communicated anything of substance to an unsuccessful job candidate.

Gift link, probably the funniest thing the Wall Street Journal has done this year.

"Changes to centers and institutes were initially projected to save $4.8 million." Bill Belichick's annual salary is $10 million.

everyone who uses an llm to code more than me is voluntarily deskilling themselves, everyone who uses it less than me might as well be hand-wiring together vacuum tubes

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

absolutely losing it at my 14yo's biology homework

Alright it's the 15th. 10 days to Christmas. Would someone in your life benefit from a calendar featuring animals??? We have 47 Love Notes From Nature calendars left. When they're gone, they're gone forever. Bonus? The proceeds fund our native plant project in Philly! Get one at SquidFacts.net!