A high aneuploidy supply rate underlies parallel evolution of fluconazole resistance in Saccharomyces cerevisiae https://www.biorxiv.org/content/10.64898/2026.07.12.738117v1

With all the July model runs now in, it is very likely that 2026 will see the largest El Niño event since records began in the late 1800s – and potentially by a truly mind-blowing margin. The median estimate is now 3.6C, roughly 0.8C hotter than the prior record (2.75C). www.theclimatebrink....

To be a historian is to speak ill of the dead and the rest of you should take more history classes and join us.

It appears the Super (Very Strong) El Niño ocean threshold has been reached at record pace (according to World Climate Service). This appears to be ~6 weeks earlier than any other time in history. The sea surface temperature anomaly in the main El Niño 3.4 region reached ~+2°C… 1/

Take a look at this new paper in @science.org Reversible suppression of autophagy in a mouse model reveals neuronal resilience | Science www.science.org/doi/10.1126/...

How do >1600 transcription factors (TFs) bind across hundreds of cell types? Experimentally profiling every combination isn't practically doable. But relying on DNA motifs isn't a great alternative -- they lack both sensitivity and specificity. #Genomics #GeneRegulation 👇

Kazuma Okamoto hits this ... to the 500 LEVEL! 😱

Neuroscientist here, who has talked about the US losing science ground to other countries: The biggest problem for generating future cures for brain diseases is the ongoing utter destruction of US basic neuroscience. It’s not about regulation.

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Process chemistry win? Meth went from $20k/lb in 2005 to $1.5-2k/lb now with improved purity to boot. Full DEA report: www.dea.gov/sites/defaul... #RealTimeChem

New paper about zero-shot predictions of mutational effects. There's a lot of misunderstanding about what such predictions can and cannot do. In brief, they're good at identifying deleterious mutations but bad at predicting fitness improvements. 1/ www.biorxiv.org/content/10.6...

Same vibe as 'Cars could drive around Central Park until 2018'

New kinds of Mad Syrup People I’ve discovered: 1. Canada?!? I’m from [US state] and we have syrup too 2. Canada?!? It’s basically all Quebec. 3. Canada?!? Indigenous people had syrup first you monster 4. Sugar water?!? Syrup is thick dummy. 5. “Maple” syrup?!? Lots of it is flavored corn syrup!

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Computational models are a key part of science but discovering new ones is hard! DataDIVER discovers concise models from data, which surface new mechanistic ideas and clear predictions for future experiments From Google Deepmind Neuroscience Lab + collaborators www.biorxiv.org/content/10.6...

This is extremely chilling - virologists being targeted for what appears to be minor (if any) "offenses". We all know _why_ this is happening, so I'm not going to belabor that point - but I want to provide some context on the technical details. 🧵 www.science.org/content/arti...

11. Addendum: here are the words characteristic of LLMs. Notice anything? It reads like an email from our upper administration.

Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog: "In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes." More: cen.acs.org/research-int...

LOL last night Stephen Colbert spent an hour hosting public access "Only in Monroe"

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!

Life hack from a marine biologist: When your blue sea dragons need a little snack, remember that they never evolved to swim, so you have to drive the Portuguese man-o-war around and pick them up like a little bus 🎥 by me during field work :)

Revival Of Internship Program Heralds CEO’s Daughter Coming Of Age https://bit.ly/3PuB1I2

May 18, 1980 | 8:32 a.m. The ground shudders. A M5.1 quake hits beneath Mount St. Helens. Weakened critically, the north face bulge collapses outward. Within seconds, a pyroclastic density surge bursts through the disintegrating slope. The clock strikes zero.

We are implementing a similar policy at @arxiv.bsky.social. If there is incontrovertible evidence of LLM slop in a paper, this means the authors did not take the time to read the LLM output and we can't trust anything else in the paper. Penalty is 1 year ban from arXiv followed by...

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr

How do fungi grow directionally? We think part of the mechanism involves local translation of mRNA near the tip, especially of cell wall components. Delighted to share our preprint showing that an RNA-binding protein, SsdA/Ssd1, is trafficked to the tip of growing fungal filaments.

FDA grants breakthrough device designation for schizophrenia/bipolar bloodtests, based on below paper with n=30 per disorder, "using 'leave-one-out' analyses, indicating that the models should be predictive when applied to independent data cohorts." Ouch. pmc.ncbi.nlm.nih.gov/articles/PMC...

It is with great sadness that we announce J. Craig Venter has died. 🧪🧬 www.jcvi.org/media-center...

This is an actual line that was added to the official system prompt for Codex for GPT-5.5 by OpenAI. Usually the system prompt is as minimal as possible, so I assume it would otherwise mention goblins a lot. AIs are weird.

UPDATE: No audience questions were taken for Jay's talk.

📣 Exciting news: my lab is moving to the Krembil Institute at the University of Toronto’s University Health Network in Fall 2026. We’ll be recruiting for all roles, so reach out if you’re interesting in joining us to study spinal circuits for sensorimotor control www.levine-lab.org

I read Vigilance by Robert Bennett a couple years ago and thought 'this is kinda over the top and a little unrealistic' I owe that book an apology

it’s First Communion Sunday at Mass which means it’s time for my favorite thing in the world: TINY FORMALWEAR

THREAD All the Colours of the Rainbow At Altmetric we look for where research has been shared and cited online. In addition to granting us permanent entry into Pride Month, the Altmetric rainbow matches different sources of attention to research that we find. What are they all? Let's go: 1/24

Would like to dedicate this post to the people who yelled at me for giving the Sabres 58% to make the playoffs in my season preview this past summer.

yes. they pay more based on income in taxes for the thing that is then “free” for everyone. this is how public services work

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

If all goes according to plan, in a few hours, a crew of astronauts will begin a journey that will take them on a loop around the moon. Here's a video that NASA put together to help people visualize the journey through space, first orbiting the earth before looping around the moon and flying home 🔭

sorry i never responded to your email, i didn't want to and then i forgot

I just heard back from the reporter, and I am genuinely speechless. Is “we don’t care” the business model?

My motivation for perservering as a statistician even when it feels bleak comes from Ian Gordon: sometimes the best we can do is make sure that the research that gets done is better than it would have been if we weren't involved in it

Check out the newest work from our, from Fabricio Nicola @fabricionicola.bsky.social on mouse jumping and spinal cell types. Excellent collab with @vulcnethologist.bsky.social www.biorxiv.org/content/10.6...

Pretty much the same reason all the gene regulatory network inference models don't work as well as people think they do

New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/ www.biorxiv.org/content/10.6...

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

sem condições esse daqui

I get asked to show up to book clubs, online and offline. Here is why from now on the answer is always "no." If you think this might have something to do with "AI" ruining yet another thing for everyone, you're absolutely 100% correct. whatever.scalzi.com/2026/03/03/i...

Critics say that Trump's war with Iran could have a lot of blowback. But there is no historical precedent for the United States overthrowing an Iranian government and then facing 50 years of hostility from Iranians.

Crap www.online-tribute.com/DavidBotstein David Botstein passed away. I worked with him at Stanford for a few years in designing and teaching a course on "The Heart". My heart is heavy right now. He was a wonderful mentor.