Arvind Varsani
@viralnomad.bsky.social
📤 793
📥 637
📝 25
Nomadic 'viral' scientist
#virome
#virus
#virus_evolution
#virology
🇰🇪🇿🇦🇳🇿
reposted by
Arvind Varsani
Spyros Lytras
28 days ago
New preprint led by our MSc student Wenye Li!! 🎉
@systemsvirology.bsky.social
What we find is a historic genetic interplay between sarbecoviruses and their horseshoe bat hosts' ACE2 receptor! 🦇 🧵...
www.biorxiv.org/content/10.1...
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Genetic diversity in horseshoe bat ACE2 and sarbecovirus spike proteins mutually shape one another
Angiotensin-converting enzyme 2 (ACE2) serves as the entry receptor for a wide diversity of sarbecoviruses naturally harboured by horseshoe bats (genus Rhinolophus ). Despite the extensive circulation...
https://www.biorxiv.org/content/10.1101/2025.10.26.684670v1
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Pathoplexus
about 2 months ago
1/ 🚀 Pathoplexus now supports Marburg virus (MARV) and Ravn virus (RAVN) (sister viruses in the same genus). MARV has two main clades and causes severe disease with reported fatality rates of 24–88%. You can read more detail about adding Marburg here:
pathoplexus.org/news/2025-11...
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The Banfield Lab
about 2 months ago
Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses
www.nature.com/articles/s41...
@luisvalentin.bsky.social
@lingdong-shi.bsky.social
@martianmicrobe.bsky.social
@mschoelmerich.bsky.social
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Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses - Nature Communications
Borgs are large extrachromosomal elements of anaerobic methane-oxidizing archaea. Here, via in silico protein structure prediction of ~10,000 Borg proteins, the authors reveal that Borgs share numerou...
https://www.nature.com/articles/s41467-025-65646-7
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Mart Krupovic
about 2 months ago
Check out our latest paper on mirusviruses, one of the most remarkable new groups of protist viruses - extremely diverse, carry lots of spliceosomal introns (including new homing introns) and are at the evolutionary crossroads between tailed phages and herpesviruses!
www.nature.com/articles/s41...
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Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes - Nature Microbiology
Environmental metagenomic explorations show that Mirusviricota lineages lack essential replication and transcription genes and contain spliceosomal introns, suggesting nuclear reproduction.
https://www.nature.com/articles/s41564-025-02190-6
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Luke Hillary
about 2 months ago
📢 New preprint is out on bioRxiv 📢: How much does virome prep influence our view of the human gut virome? Short answer: a lot. Long answer:
doi.org/10.1101/2025...
Different methods lead to distinct community structures, richness, and major virus-host abundance patterns. 🧵 1/5
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Sam J Wilson
about 2 months ago
How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
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Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
https://www.science.org/doi/10.1126/science.adq4691
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Quanta Magazine
about 2 months ago
According to the microbial ecologist Puri López-García, pictured here at a salt flat in the Chilean Andes, some 25% to 50% of all bacterial cells may be parasites of other cells.
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A Cell So Minimal That It Challenges Definitions of Life | Quanta Magazine
The newly described microbe represents a world of parasitic, intercellular biodiversity only beginning to be revealed by genome sequencing.
https://www.quantamagazine.org/a-cell-so-minimal-that-it-challenges-definitions-of-life-20251124/
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Arvind Varsani
Robert J. Gifford
about 2 months ago
"The hyperreal bat: more vivid, more coherent, and more narratively satisfying than any bat in nature." Why does the idea of bats as special viral reservoirs endure? New Substack post:
robertjgifford.substack.com/p/bats-and-v...
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Bats and Viruses: Rumour, Intrigue, Deception, and Spectacle
Bats as Hyperreal Reservoirs of Viral Disease
https://robertjgifford.substack.com/p/bats-and-viruses-rumour-intrigue
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Tominaga K. (tomiken)
about 2 months ago
Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments | Nature Communications
https://www.nature.com/articles/s41467-025-65461-0
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Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments - Nature Communications
The ecological role of viruses for CPR bacteria and DPANN archaea remains understudied. Here, the authors apply metagenomic approaches to study the biogeographic distribution of CPR and DPANN viruses in acid mine drainage sediments and elucidate their complex interplays.
https://www.nature.com/articles/s41467-025-65461-0
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Diversity of polyomaviruses and papillomaviruses in penguins from eastern and western Antarctica -
www.microbiologyresearch.org/content/jour...
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Diversity of polyomaviruses and papillomaviruses in penguins from eastern and western Antarctica
Polyomaviruses and papillomaviruses are icosahedral viruses with small circular dsDNA genomes. Limited information on their diversity and evolution in avian hosts is available, with even less known re...
https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001580
about 2 months ago
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Arvind Varsani
Polar Observer
about 2 months ago
Studying penguin virology in
#Antarctica
:
@arizonastateuni.bsky.social
researchers lead in discovery of new viruses in Antarctic penguins, expanding knowledge of polar ecosystems
@viralnomad.bsky.social
news.asu.edu/b/20251124-s...
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Arvind Varsani
Dr Michelle LaRue
about 2 months ago
Oh no! 🧪🌎🦑🦉🦊
add a skeleton here at some point
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Arvind Varsani
Gemma Langridge
3 months ago
🚨 Another funded PhD alert🚨 We are recruiting again! For a PhD student to start with us in the
@langridgelab.bsky.social
October 2026 - please share 👀 If you are interested in foodborne pathogens, public health and phage, look no further 🦠🏥🧬 ➡️
tinyurl.com/3zvavp2t
⬅️ Apply by 6 Jan 2026 🗓️
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Elin Videvall
3 months ago
📢 We have an open position for a postdoc to join my lab. It's a great position
@animecol-uu.bsky.social
, fully salaried for 2.5 years with all benefits.
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)
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Postdoctoral researcher in molecular ecology - Uppsala University
Postdoctoral researcher in molecular ecology, Department of Ecology and Genetics, Uppsala University
https://www.uu.se/en/about-uu/join-us/jobs-and-vacancies/job-details?query=867654
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Jeremy Keown
3 months ago
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.
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Dr Jeremy Keown
Dr Jeremy Keown
https://warwick.ac.uk/fac/cross_fac/mibtp/phd/supervisors/JKeown/#pathogenic_RNA
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Arvind Varsani
Crystal Rogers, PhD
3 months ago
Our department
@ucdavisvetmed.bsky.social
@ucdavis.bsky.social
is hiring! We welcome research that diversifies or complements existing strengths in gastrointestinal, neuroimmune, musculoskeletal, cardiorespiratory systems and/or developmental biology.
@socdevbio.bsky.social
@ascbiology.bsky.social
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Arvind Varsani
ace-gtdb.bsky.social
3 months ago
Our
@narjournal.bsky.social
manuscript is out! It explores the growth of the GTDB (
gtdb.ecogenomic.org
) since its inception, as well as updates to the website, methodology, policies, and major taxonomic and nomenclatural changes over the past three years.
academic.oup.com/nar/advance-...
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GTDB release 10: a complete and systematic taxonomy for 715 230 bacterial and 17 245 archaeal genomes
Abstract. The Genome Taxonomy Database (GTDB; https://gtdb.ecogenomic.org) provides a phylogenetically consistent and rank normalized genome-based taxonomy
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1040/8296754
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Arvind Varsani
Simon Roux
3 months ago
Now published: EnVhogDB, a large database of viral protein family HMM profiles to help functional annotation of new phage genomes -
peercommunityjournal.org/articles/10....
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EnVhogDB: an extended view of the viral protein families on Earth through a vast collection of HMM profiles
https://peercommunityjournal.org/articles/10.24072/pcjournal.627/
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Arvind Varsani
Carl Zimmer
3 months ago
Pandas, snow leopards...and bacteria. A newly formed team of scientists is setting out to conserve the world's diversity of microbes. Here's my story:
nyti.ms/47vEfRC
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Rob Klose
3 months ago
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost!
tinyurl.com/mr3m7bd3
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Stefan Rothenburg
3 months ago
Now with the correct link: We reviewed the "Molecular Mechanisms of Poxvirus Evolution" We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
journals.asm.org/doi/10.1128/...
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Mart Krupovic
3 months ago
Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with
@deemteam.bsky.social
,
@anagtz.bsky.social
and Michail Yakimov Free access link:
rdcu.be/eLtCH
🧵 by
@yifanzhou.bsky.social
👇
add a skeleton here at some point
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Nanami Kubota
3 months ago
Excited to see our recent paper get covered by Pitt media!
add a skeleton here at some point
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Louise H. Moncla
3 months ago
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution
academic.oup.com/ve/article/1...
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Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Abstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species.
https://academic.oup.com/ve/article/11/1/veaf058/8221740
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Arvind Varsani
Jeremy Barr
3 months ago
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
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Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
https://nature.com/articles/s41586-025-09614-7
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Frances Separovic
3 months ago
Maud Menten was born in Canada in 1879 and completed her UG and MD education at University of Toronto. As a research assistant with Leonor Michaelis in 1912, they wrote the classic paper describing the “Michaelis-Menten” model of enzyme kinetics..
#WomenInScience
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Christian Kost
3 months ago
Check out this great opportunity to metabolically model microbial communities 👇
add a skeleton here at some point
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Jörg Vogel
3 months ago
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
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Asher Leeks
3 months ago
I gave a talk last year at TEDxNewEngland aimed at introducing the idea of viral sociality to a general audience, including implications for evolution & virology. Video now available online below.
#socialviruses
#evosky
#virosky
🧪
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The social lives of viruses | Asher Leeks | TEDxNewEngland
YouTube video by TEDx Talks
https://www.youtube.com/watch?v=t3hjnRL5y7E
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Arvind Varsani
RCSB Protein Data Bank
3 months ago
The genome of ebola virus contains instructions for building seven proteins, which assemble with the genomic RNA to form one of the deadliest viruses.
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PDB101: Molecule of the Month: Ebola Virus Proteins
Structures of ebola virus proteins are giving new hope for fighting this deadly virus
https://pdb101.rcsb.org/motm/178
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Arvind Varsani
Jessica Metcalf
3 months ago
Benny and Estelle about talking about malaria and cyclones on Wednesday 8th at 12:00 EST:
duke.zoom.us/meeting/regi...
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Welcome! You are invited to join a meeting: Club EvMed - Extreme Weather and Malaria Control. After registering, you will receive a confirmation email about joining the meeting.
Welcome! You are invited to join a meeting: Club EvMed - Extreme Weather and Malaria Control. After registering, you will receive a confirmation email about joining the meeting.
https://duke.zoom.us/meeting/register/ambgeFXlQWuiZoAtyHpHzw#/registration
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Arvind Varsani
Tominaga K. (tomiken)
3 months ago
A functional cyanophage thioredoxin increases competitive phage fitness | bioRxiv
https://www.biorxiv.org/content/10.1101/2025.10.05.680603v1
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A functional cyanophage thioredoxin increases competitive phage fitness
Thioredoxins are ubiquitous redox proteins that are found in all domains of life. These conserved proteins are also found in many phages, including marine cyanophages that infect the ecologically important marine cyanobacteria. However, their role in phage infection is not known. Cyanophages also carry many small genes lacking homology to known functional domains. Whether these have a functional role or not remains unknown. Here, we explore the distribution and role of a cyanophage thioredoxin (trxA), and that of a small gene directly downstream of it (g26), in phage infection. For this we used the T7-like cyanophage, Syn5, which infects an open-ocean marine Synechococcus strain, WH8109. We found that thioredoxin genes are common in phage genomes, including in cyanophages. The g26 gene, however, is restricted in it distribution to the cyanophages. The cyanophage thioredoxin is catalytically active and it increases phage DNA replication, progeny production and competitive fitness. It also negatively impacts host growth. The g26 gene product is translationally coupled to, and thus dependent on, translation of the thioredoxin gene. This gene itself significantly increases phage virulence and fitness, yet reduces burst size. Our findings demonstrate that cyanophage thioredoxins impact phage fitness and infection physiology and that small viral genes with no homology to known genes can play an important role in the infection process. These findings provide insights into the importance of unusual genes in phage genomes and show that they are likely to play an important role in the interactions between abundant cyanobacteria and cyanophages in ocean ecosystems. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2025.10.05.680603v1
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Oliver Bossdorf
3 months ago
JOB ALERT! Do you also love large ecological experiments? Become coordinator of our big new geo-biosphere experiment in
@terra-cluster.org
. 7-year position! Follow link for details.
@gfoesoc.bsky.social
@britishecologicalsociety.org
@ecologicalsociety.bsky.social
@uslter.bsky.social
Please repost!
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Stellenangebote: Universität Hohenheim
Aktuelle Stellenangebote der Universität Hohenheim.
https://www.uni-hohenheim.de/stellenangebote?tx_unijobs_joboffers%5Bjoboffer%5D=4313&tx_unijobs_joboffers%5Baction%5D=show&tx_unijobs_joboffers%5Bcontroller%5D=Joboffer&cHash=e7ae7a82d04f0d7f01b79edb41ac2534
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Dr Michelle LaRue
3 months ago
When I was on the ice w Nat Geo, we visited the emperor penguins at Atka Bay which is a colony that hops up onto the ice shelf rather than staying only on sea ice. This means that when chicks fledge they have a high-dive of a jump to reach the water. Which they do. With spectacular inelegance. 🧪🌍🦑🦉
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Greg Copenhaver
3 months ago
The
@uncchapelhill.bsky.social
Department of Biology is searching for tenure-track Assistant Professor in Plant Molecular Biology. Chapel Hill is a wonderful place and Biology is an amazing group of people. To apply, see:
unc.peopleadmin.com/postings/307...
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Kerry J. Laing, PhD
3 months ago
Our little herpes vaccine study got published. Thanks to coauthors and study sites and volunteers. Also, thanks to the reviewers for appreciating the scientific contributions despite the limitations of a small trial. 🧪💉https://www.sciencedirect.com/science/article/pii/S0264410X25011181
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Safety and immunogenicity of investigational herpes simplex virus-2 vaccines in adults with recurrent genital infection
HSV529 and G103 are investigational therapeutic vaccines for genital herpes. HSV529 is a replication-defective HSV-2. G103 contains three recombinant …
https://www.sciencedirect.com/science/article/pii/S0264410X25011181
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Arvind Varsani
Spyros Lytras
4 months ago
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬 Work with
@ulad-litvin.bsky.social
,
@grovearmada.bsky.social
, Alex Jack,
@bljog.bsky.social
,
@davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
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Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for >4,400 viruses, allowing mapping of form and function across the human and animal virosphere. Viro3D i...
https://www.embopress.org/doi/full/10.1038/s44320-025-00147-9
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Evgenii Protasov
4 months ago
“Paraxenoviridae”, a putative family of globally distributed marine bacteriophages with double-stranded RNA genomes
#viruses
#bacteriophages
#phages
@isme-microbes.bsky.social
academic.oup.com/ismej/articl...
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“Paraxenoviridae”, a putative family of globally distributed marine bacteriophages with double-stranded RNA genomes
Abstract. Metatranscriptome sequencing dramatically expanded the known diversity of the global RNA virome and, in particular, suggested several new candida
https://academic.oup.com/ismej/article/19/1/wraf139/8185998
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Ariel Waldman
4 months ago
SF BAY AREA! You are invited to a sneak peek screening of my documentary ANTARCTICA UNEARTHED before it goes to national TV broadcast next year. Wednesday, October 15 at 7pm near Palo Alto, CA. Free to attend but registration required:
arielwaldman.com/screening
(cc
@darthbluesky.bsky.social
)
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Screening — Ariel Waldman
https://arielwaldman.com/screening
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Vaughn Cooper
4 months ago
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine. 1) MMG (my dept): fundamental research in med micro 2) Peds ID / I4Kids institute 3) Center for Vaccine Research 🔗 to all 3 w/info:
www.linkedin.com/posts/vaughn...
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Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...
https://www.linkedin.com/posts/vaughn-cooper-phd_faculty-professor-associate-full-time-activity-7376380337452523520-4gOG?utm_source=share&utm_medium=member_desktop&rcm=ACoAAADLnXgB4CLKDX_tz7MjuN96IBzkSWha36w
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Cedric Feschotte
4 months ago
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the
@weillinstitute.bsky.social
PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
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Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
https://academicjobsonline.org/ajo/jobs/30607
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Rachel Maddow
4 months ago
"The group brings together hundreds of grandparents nationwide who lived through diseases such as polio, tuberculosis and measles — illnesses once thought eliminated in the United States..."
www.kgw.com/article/news...
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Grandparents for Vaccines launches to share stories of life before immunizations
New volunteer group aims to educate parents about vaccine importance by sharing personal experiences with preventable diseases.
https://www.kgw.com/article/news/health/grandparents-for-vaccines-stories-life-before-immunizations/283-27bf3ad5-ca2f-4df8-afb6-255d25e62931
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British Society of Plant Pathology
4 months ago
Time to grab your abstract booklet and a cup of tea
#PPATH2025
#ECPP2025
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Arvind Varsani
Antoni Wrobel
4 months ago
Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
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ASM
4 months ago
Microbiology Monday: Organoids—cellular orbs that mimic real tissue structure and function—are revolutionizing how we study viral pathogenesis, screen antiviral drugs and accelerate vaccine development. 🧫 Learn more in
#JVirology
:
asm.social/2zZ
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Jennifer Biddle
4 months ago
This is the dept where I got my PhD! Hiring for microbiology!
add a skeleton here at some point
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Dan Sloan
4 months ago
The Department of Biology at Colorado State University is hiring an Assistant Professor in the area of plant-microbe interactions! Please spread the word!
jobs.colostate.edu/postings/165...
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Assistant Professor Plant-Microbe Interactions
We seek a creative, collaborative, and visionary plant biologist to establish an internationally recognized research program at the forefront of plant-microbe interactions aimed at understanding how t...
https://jobs.colostate.edu/postings/165524
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Quanta Magazine
8 months ago
Manu Prakash invented “frugal science” tools that drastically reduce the cost of diagnosing malaria.Talking to
@mollyherring.bsky.social
, he discusses the advantages of following curiosity: “Observation is a practice, and if you don’t practice, you lose it.”
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How Paradoxical Questions and Simple Wonder Lead to Great Science | Quanta Magazine
Manu Prakash works on the world’s most urgent problems and seemingly frivolous questions at the same time. They add up to a philosophy he calls “recreational biology.”
https://www.quantamagazine.org/how-paradoxical-questions-and-simple-wonder-lead-to-great-science-20250528/
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Anna Frangou
6 months ago
Manu Prakash - a beautiful combination of working on the world's most pressing problems & looking at stuff because it's interesting with no idea what the outcome or use could be. Both are massively valuable & that both is and isn't the point. Make sure to play.
www.quantamagazine.org/how-paradoxi...
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How Paradoxical Questions and Simple Wonder Lead to Great Science | Quanta Magazine
Manu Prakash works on the world’s most urgent problems and seemingly frivolous questions at the same time. They add up to a philosophy he calls “recreational biology.”
https://www.quantamagazine.org/how-paradoxical-questions-and-simple-wonder-lead-to-great-science-20250528/
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Ákos T Kovács
4 months ago
Phage defence-system abundances vary across environments and increase with viral density Phil. Trans. R. Soc. B by
@seanmeaden.bsky.social
, Edze Westra and
@peterfineran.bsky.social
royalsocietypublishing.org/doi/10.1098/...
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Phage defence-system abundances vary across environments and increase with viral density | Philosophical Transactions of the Royal Society B: Biological Sciences
The defence systems bacteria use to protect themselves from their viruses are mechanistically and genetically diverse. Yet the ecological conditions that predict when defences are selected for remain ...
https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0069
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