Anna Docherty (@annadocherty.bsky.social)

Characterizing the genetic architecture of drug response using gene-context interaction methods Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction. https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00351-3