One day in the 1980s, Wilma Pelly injured her hand at her factory job. While she recovered, she decided to try out acting. What started with work as an extra, led to her beloved role as Elsie on North of 60 and a successful acting career. This is her story. 🧵 1/8

#COVID19 vaccination before or during pregnancy was associated with lower risks of hospitalization, ICU admission, and preterm birth among those infected with SARS-CoV-2 in Canada. ja.ma/45gaS4e

Please, please get your vaccines. Good for you. Good for community. Good for healthcare system. Emergency wards coping with 'extreme overcapacity' in flu season: cbc.ca/news/canada/... #VaccinesWork

💡 PASSERELLE’s Trainee Advisory Committee led Canada’s first national survey on the needs and experiences of trainees in patient-oriented research (POR). Key takeaway: While most value POR, fewer feel confident leading it. 📖 The full report will be released in 2026.

Science is built on many voices, not one institution. A single surprising statement, even from a familiar or historically trusted source, doesn’t replace the wider consensus. But how to gauge reliability?👇 scienceupfirst.com/misinformati... #ScienceUpFirst

Child deaths under 5 believed to be rising for first time in decades wapo.st/3KIeg0N "Immunizations 'remain the best buy in global health.'" "If funding cuts persist ... 12 million more children under 5 could die by 2045." Thx, MAGA.

🎥 Missed a PASSERELLE webinar this year? Watch recorded sessions on patient-oriented research, best practices & innovative approaches. Thanks to our amazing speakers & everyone who joined! 👉 www.youtube.com/@PASSERELLE-...

NEW! Health economic evaluation of the REVISE trial: 50-Cent Drug Could Save Hospitals Thousands of Dollars www.newsweek.com/50-cent-drug...

Did you know that not all scientific evidence has the same weight? The more the study relies on an expert's opinion, rather than many data points and peer-review, the higher the risk of bias. 🔺https://www.scienceupfirst.com/project/hierarchy-of-evidence/ #ScienceUpFirst

Surging measles cases could augur poorly for other diseases, @who.int says www.cbc.ca/news/health/... What it will take for Canada to regain its measles elimination status? "Better communication, building trust with undervaccinated communities & fighting misinformation."

Hello #HamOnt! On Oct 16th I'll be at the @hamiltonlibrary.bsky.social talking about fascinating research on how vaccinations protect the aging brain. It's free, it's fun, and I would love to see you all there. Register below. @miramcmaster.bsky.social

This World Sepsis Day, 98 structures will illuminate pink across Canada to raise awareness of sepsis! Not only does this break 2024’s record, but this year will also see the first illumination in one of Canada’s 3 territories. A key moment in raising awareness in the North.

Thank you to the governments of Alberta, British Columbia, New Brunswick, Nova Scotia, Prince Edward Island, Saskatchewan, and the Yukon for officially proclaiming World Sepsis Day 2025. This stands as a critical contribution to raising awareness of sepsis throughout Canada!

It is important to recognize both physical and mental health impacts when helping survivors recover from sepsis. Here is Amalie sharing her mental health experiences both before and after sepsis. #SepsisAwarenessMonth #WorldSepsisDay #SepsisAwareness #Sepsis #SepsisSurvivor

Video in Clinical Medicine: Abdominal paracentesis can be performed as either a diagnostic or a therapeutic procedure. The use of ultrasound for guiding paracentesis generally results in fewer complications and increased operator comfort and procedure success rates. nej.md/3I1o5FN

In the new book Labwork to Leadership, chemist Jen Heemstra offers actionable leadership advice to principal investigators. Check out the #ScienceBooks Review on #ReadABookDay: https://scim.ag/46l2X6y

Staphylococcus aureus bacteremia has a case fatality rate of 15% to 30% and causes 300 000 deaths per year worldwide. This Review discusses management of S aureus bacteremia. ja.ma/47lAvCO #MedSky

Whether lactated Ringer’s solution is clinically superior to normal saline for routine intravenous administration of fluids to hospitalized patients is unclear. Research findings from the FLUID trial are summarized in a new Quick Take video. nej.md/4oCRgQ4 #MedSky #CriticalCare

oh, not nearly as good as one might hope

Organizations disinvited from CDC vaccine workgroups medicalxpress.com/news/2025-08... - American Medical Association - American Academy of Pediatrics - Infectious Diseases Society of America, et al Removal "irresponsible, dangerous to our nation's health, & will further undermine public trust..."

Jackie Duda is a BEAST!!! This woman does so much advocating for sepsis awareness & changing lives for the better for all sepsis survivors. This is her latest article in @thelancet.com. www.thelancet.com/journals/lan...

Ventilator-associated pneumonia: mechanisms, an appraisal of current therapies and the role for inhaled antibiotics in prevention and treatment CCR Journal Watch - tracking the critical care literature daily https://criticalcarereviews.com/latest-evidence/journal-watch

🚩The 3rd trial result for CCR Down Under 2025 is ARISE-AFRICA🚩 ➡️Standard low flow oxygen vs nasal high flow oxygen vs CPAP in hypoxaemic respiratory failure ➡️Presenter Arthur Kwizera ➡️Join us in Melbourne criticalcarereviews.com/meetings/ccr... @precordialthump.bsky.social

Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis go.nature.com/4lzilSb

Maria Montessori and her many disciples believed that children are, in their essence, methodical, self-directed beings with a strong work ethic.

Mastercard Foundation Scholars Program at my university @mcgill.ca Fully-funded scholarship to Canada!! opportunitiesforyouth.org/2025/07/14/m...

Tackling misinformation is a long game: journalists can help www.absw.org.uk/resources/ta... v @absw.bsky.social 1) Publish on a topic widely & repeatedly 2) Prebunk—inoculate your audience against common misinformation tactics 3) Report on science with extreme care 4) Choose your experts carefully

Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies CCR Journal Watch - tracking the critical care literature daily https://criticalcarereviews.com/latest-evidence/journal-watch

Happy to share this collaboration between my undergraduate student, a post doctoral fellow and patient partners healthydebate.ca/2025/07/topi...

#ICUreadings One of my favorite recent meditations on the language we use, by the brilliant @jackykruser.bsky.social: pubmed.ncbi.nlm.nih.gov/37486663/ And the classic DAHLIA trial that is part of why I am so liberal with precedex: pubmed.ncbi.nlm.nih.gov/26975647/

In effort to protect children, France bans smoking at parks, pools, beaches, and or "anywhere children may be present," by @ebeardsley.bsky.social www.npr.org/2025/06/30/n... via @npr.org

I’m grateful that these people are willing to share their stories, hopefully so that others can avoid their fate. There is a reason that specific infections have been targeted by vaccines. Vaccine-preventable diseases are terrible.

An immigration crackdown makes the United States less attractive. Where should you hold your next conference? https://go.nature.com/407qJ2w

#Measles is surging in Alberta. Which vaccine-preventable disease could be next? Measles 'canary in the coalmine,' as experts watch for resurgence of illnesses like polio, by @jenleecbc.bsky.social www.cbc.ca/news/canada/... via @cbcnews.ca #pediatrics

#Measles leaves children vulnerable to other diseases for years. Measles causes more than an acute illness: it suppresses immune memory and increases the risk of complications for years, by @scientificdiscovery.dev ‬ ourworldindata.org/measles-incr... via @ourworldindata.org

Today's Paper of the Day is: Protocolized strategies to encourage early mobilization of critical care patients: challenges and success criticalcarereviews.com/latest-evide... Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67 @criticalcarereviews.com #CCR25

#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation #CCR25

Presented at #CCR25: In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs @criticalcarereviews.com

🚨 FLUID Trial Results🚨 Balanced crystalloids vs saline in hospitalised patients 📍 16 Canadian hospitals 👥 >144,000 pts 😮 🏁 Cluster-crossover RCT 📊 90-day death or readmission ➡️ Big trial ! ➡️ Big numbers ! 🚩 The answer drops at #CCR25🚩

B҉A҉C҉T҉E҉R҉I҉A҉L҉ ҉E҉N҉E҉R҉G҉Y҉ ҉V҉A҉M҉P҉I҉R҉E҉ 𝘓𝘦𝘨𝘪𝘰𝘯𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘱𝘩𝘪𝘭𝘢’s Dot/Icm system secretes actin-dependent ATPase Ceg14 to the cytoplasm Ceg14 depletes ATP; metaeffector AnkJ restrains its activity Result—dynamic regulation of host energy stores to favor bacterial replication www.nature.com/articles/s41...

Private health clinics in Canada are selling patient information: study www.ctvnews.ca/health/artic... @ctvnews-rss.bsky.social

Oncologists call cancer a disease. Why do intensivists call sepsis a syndrome? A disease is a disorder that affects how your body functions with a known cause, a distinct course and established treatments. If we called sepsis a disease we might have investment in finding therapies just like cancer.

CDC reports 216 child deaths this flu season, the most in 15 years www.statnews.com/2025/05/02/c... via @statnews.com Big reason: fewer getting flu vaccine, which is "highly effective at preventing hospitalizations and deaths." #VaccinesWork & misinformation kills.

There has been a significant reduction in the number of kids getting the flu vaccine over the past 5 years—a drop from 64% to 49%. Consequently, there have been 216 pediatric flu deaths so far this flu season, the highest number since the swine flu 15 years ago (link below). Vaccinate.

"Health systems can take steps to mitigate inhaler-related greenhouse gas emissions expeditiously." This Perspective discusses the environmental impact of metered-dose inhalers used for respiratory conditions. #MedSky ja.ma/4cWmpbL

Here we go. A major conference on antimicrobial resistance (GAMRIC) scheduled for later this year has been moved from Washington DC to London. Email from the organizers: "In order to maximise global participation..." (NB that they say nothing about moving *from* DC. But it WAS in DC.) 🧪

Receiving a COVID-19 booster vaccine in the same arm as the first vaccine dose leads to a faster, more effective immune response than having it in the opposite arm. https://go.nature.com/42WwKzT

Important opinion piece by MD/PhD student @kevinterleukin.bsky.social on why sex and gender research is important. He studies sex differences in immunity and as a clinician will need to be aware why drug side-effects, certain diseases, and outcomes differ by sex. This work shouldn't be politicized.

Herpes zoster vaccination eligibility reduced the probability of new dementia diagnoses, suggesting its potential preventive effect. #WVCDC #WorldVaccineCongress