New in @NEJM: CCCTG and @anzics.bsky.social have published the SuDDICU study www.nejm.org/doi/full/10....

In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8 #LIVES2025 | @esicm.bsky.social

Consent documentation for clinical research guideline: A core set of elements for participant consent documents to be used in clinical research across Canada. ➡️ www.cmaj.ca/lookup/doi/10.1503/cmaj.250500

📣 The CCCTG and CIHR’s Ethics Office created a guideline for a simplified template for informed consent - published TODAY in ‪@cmaj.ca‬ See the full guideline: www.cmaj.ca/lookup/doi/1...

Tomorrow: In recognition of her pioneering research in critical care medicine, Dr Deborah Cook will be inducted into the Canadian Medical Hall of Fame. Congratulations to the 2025 Laureates! Details: www.cdnmedhall.ca/news/six-out... @cmadocs.bsky.social

INdex @ccctg.bsky.social @criticalcarereviews.com

From JAMA Neurology: CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria. #CCR25 @criticalcarereviews.com ja.ma/3TeogPR

Happening now! INdex Study Results at #CCR25. Catch the livestream: criticalcarereviews.com

Lauralyn McIntyre & Monica Taljaard summarise the FLUID trial presented yesterday at the Critical Care Reviews Meeting 2025 and simultaneously published in the @nejm.org www.nejm.org/doi/full/10....

INdex Trial Results, coming up at Critical Care Reviews in Belfast! Watch at 10:20AM Eastern for those tuning in from Canada. Free livestream: criticalcarereviews.com #CCR25

PROMIZING Trial Results presented at #CCR25 in Belfast. Congrats to Dr Karen Bosma and the PROMIZING team. See the full trial results in @nejm.org

PROMIZING [email protected] @criticalcarereviews.com #CCR25

#PROMIZINGtrial results are in - no difference in time to successful liberation from mechanical ventilation between proportional-assist ventilation and pressure support ventilation #CCR25

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results: nej.md/4kC2a67 @criticalcarereviews.com #CCR25

FLUID trial results are coming thick and fast! 📰 Use of Ringer’s lactate, when compared with normal saline, did not modify survival or hospital readmission within 90 days in a hospital-wide intervention!

The FLUID Trial Results were just presented at #CCR25 in Belfast. Congrats to the FLUID team! See the full trial results in @nejm.org: www.nejm.org/doi/full/10....

Presented at #CCR25: In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs @criticalcarereviews.com

Also the trial was fully data enabled allowing outcomes to be collected via routine data making the data collection super efficient 3/3

Neat features including use of routine healthcare data to estimate the likely ICC and cluster autocorrelation coefficient which gave accurate estimates for the sample size calcs 2/3

Another super cluster crossover trial at #CCR25 - the FLUID trial (looking at Ringers lactate vs normal saline - at the system level). 1/3 See paper here … www.nejm.org/doi/full/10....

⏰ Coming up at 10:30 ET: Don't miss FLUID Trial Results, live from #CCR2025 in Belfast! Catch Dr Lauralyn McIntyre's presentation on the livestream criticalcarereviews.com

Now we have Prof Niall Ferguson from Toronto providing an editorial ... and he begins with some 18th century philosophy! #CCR25

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com

🚨 12 Major Critical Care Trials 🚨 🌟 Global experts 🗣️ Live discussion 📺 Join the free livestream of #CCR25 – where critical care meets cutting-edge evidence 💡 🌍 Streaming the latest trials & analysis you don't want to miss 📊🧪 🔗 https://criticalcarereviews.com/meetings/ccr25

Thank you to all speakers at Spring Canadian Critical Care Translational Biology Group (CCCTBG) meeting in Magog, QC! 🇨🇦 Inspiring talks on microvascular monitoring in shock, immune responses in critical illness, preclinical models, endothelial protection in shock, and neuroprotection post-stroke 👏

Deadline extension: Apply by May 26! 👇

Are you passionate about health research? Our colleagues at the LifTING Health Research Training Program have opened applications for their 2025-2027 virtual cohort. Check out the ✨NEW✨ LifTING website for details: liftingsepsiscanada-hrtp.ca/home

"In combining data with scientific excellence, Canada can emerge as the best jurisdiction globally for health care innovation." www.theglobeandmail.com/opinion/arti...

🚨 Save the Date! 🚨 🌍 In 38 days, we celebrate the #PedsICU community worldwide! 📢 WFPICCS announces the World PICU Awareness Week 2025 focusing on the theme "Technology and Innovation in PICU" Learn more here: wfpiccs.org/2025-world-p... Stay tuned! #WPAW25 #WFPICCS

In the BALANCE trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results and Research Summary: nej.md/3Z5bTJD #MedSky #CriticalCare #IDSky

CCCTG congratulations to our Vice Chair for this much-deserved honour! 🎉

Impact Story: Tapping the research potential of community hospitals www.ccctg.ca/news-events/...

This week Paula Sevestre represented CCCTG at the Chiefs of Ontario 18th Annual Health Forum where she presented "Building Awareness and Fostering Collaboration: Understanding Critical Care in Indigenous Communities." Thanks to Chiefs of Ontario for having us, and to those who attended the session.

Congratulations! 🎉 At the CCCTG Winter 2025 Scientific Meeting, @drfoxrob.bsky.social was presented with the Deborah J. Cook Mentorship Award in recognition of her outstanding multidisciplinary mentorship. www.ccctg.ca/news-events/...

The ninth trial result for #CCR25 in Titanic Belfast in June is INdex CT-perfusion for the Neurological Determination of Death Investigators - Michaël Chassé & Jai Shankar Register at https://criticalcarereviews.com/meetings/ccr25

The 10th presentation at #CCR25 is RESCUE 3 Temporary Transvenous Diaphragm Pacing vs Standard of Care for Weaning From Mechanical Ventilation Register via the QR code or on the CCR website Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World

We’re excited to be on Bluesky & connect with our members & the global #PedsICU community!

@ccctg.bsky.social the best place to discuss/prepare future projects ! With the best #pedsICU team ! @cra-chusj.bsky.social

The sixth trial result for #CCR25 in Titanic Belfast in June is PROMIZING Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Register at criticalcarereviews.com/meetings/ccr25

Original Article in NEJM Evidence “Leg Cycle Ergometry in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis” by O'Grady et al. eviden.cc/3YiVbVV @khome1.bsky.social

Great collaborative work by A Kawagushi /P Jouvet on Prolonged vent in #PedsICU across the globe. A complex and frequent (25% prevalence) condition, with high mortality rate. Heterogeneity reflecting between site differences...and the lack of evidence... www.sciencedirect.com/science/arti...

👀 Three @nejm.org publications over the past six months. Warm CCCTG congratulations to our HEMOTION, BALANCE and SAHaRA colleagues on their outstanding dedication and teamwork!

"It’s not a competition — it’s synergy" 🤝 Dr. Jennifer Tsang on transforming research collaboration with the Niagara Health Knowledge Institute and the Canadian Community ICU Research Network (CCIRNet) niagarahealth.on.ca/site/news/20...

Presented at #CCRDownUnder: In the SAHARA trial involving patients with subarachnoid hemorrhage and anemia, liberal transfusion of red cells did not result in a lower risk of an unfavorable neurologic outcome than a more restrictive strategy. nej.md/4ilTVdO

Chief Investigator Shane English and Senior Investigator Anthony Delaney share their findings from the #SAHaRAtrial at #CCRdownunder

SAHaRA trial comes up 🏥Subarachnoid hemorrhage 50% have anaemia (associated with poorer outcomes) 🩸liberal vs. restrictive red blood transfusion 📝 RCT 🎯 modified Rankin Scale + FIM, 5EuroQOL at 12mth #CCRdownunder #CCRdownunder24

Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell & Outcome (SAHaRA) No stat significant primary outcome difference between the 2 groups. (Hb trigger ≤100g/L vs ≤80g/L respectively) #CCRdownunder

Excited to learn the results from SAHaRA - simply a stunning venue

Hello Bluesky! 🌛 Coming up tonight: Don't miss SAHaRA trial results, live from Melbourne! Catch the livestream using the link below at 11:30 p.m. Eastern Standard Time. #ccrdownunder