RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults – The Bottom Line #foamed #foamcc www.thebottomline.org.uk/summaries/ic...

Etomidate • LITFL Critical Care Compendium #foamed #foamcc Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial litfl.com/etomidate/

Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses

The Worlds Best Intensive Care Meeting is up and running - Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)

Co-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder Livestream -> www.criticalcarereviews.com @jama.com

In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB @criticalcarereviews.com

Chief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results. Livestream -> www.criticalcarereviews.com @jama.com

Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder Livestream -> www.criticalcarereviews.com @jama.com

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

RSI trial now starting ➡️ Etomidate vs Ketamine for RSI ➡️ Jonathan Casey & Matthew Semler presenting ➡️ Chris Nickson editorialising ➡️ Join the livestream - criticalcarereviews.com #ccrdownunder

Congratulations to the RSI trial team #CCRdownunder

Wow wow wow Beautiful trial. Nice editorial. Worth watching if you intubate patients.

Editorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3

Second at #ccrdownunder - #IREHABtrial Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com

Precision Therapy for Sepsis: The End of the Beginning? | Critical Care Medicine | JAMA | JAMA Network #ccrdownunder 2025 jamanetwork.com/journals/jam...

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis. #CCRdownunder ja.ma/4pMi8wt

ImmunoSep uses a double-dummy design. What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder

IMMUNOSEP trial - JAMA jamanetwork.com/journals/jam... #ccrdownunder 2025

Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!

Up first at #ccrdownunder - #IMMUNOSEPtrial Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com

Struggling to keep up with the critical care literature? ➡️ We search it daily & curate the best papers ➡️ Delivered to your inbox each weekend ➡️ Try our Newsletter - there's nothing else like it Sample - criticalcarereviews.com/newsletters/... Subscription - criticalcarereviews.com/newsletters/...

There are now just under 50 days to CCR Down Under 2025. The programme is out - 8 superb trial results coming up. Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world! criticalcarereviews.com/meetings/ccr...

The 5th trial to be announced for CCR Down Under 2025 is ACTiVE Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients Join us in Melbourne, either in-person or online criticalcarereviews.com/meetings/ccr...

CCR Down Under 2025 - december 9th & 10th 2025 Melbourne is the place to be! Registrations are open 😁: criticalcarereviews.com/meetings/ccr... See you there! @criticalcarereviews.com

🚩The 3rd trial result for CCR Down Under 2025 is ARISE-AFRICA🚩 ➡️Standard low flow oxygen vs nasal high flow oxygen vs CPAP in hypoxaemic respiratory failure ➡️Presenter Arthur Kwizera ➡️Join us in Melbourne criticalcarereviews.com/meetings/ccr... @precordialthump.bsky.social

CCR Down Under 2025 - december 9th & 10th 2025 Melbourne is the place to be! Registrations are open 😁: criticalcarereviews.com/meetings/ccr... See you there! @criticalcarereviews.com

Looking forward to this!

Dobutamine litfl.com/dobutamine/ I don’t often use dobutamine, but when I do I make sure I know about its cool racemic pharmacology (and the major clinical trials) #foamed #foamcc

Suspended animation litfl.com/suspended-an... Ok, not really a core crit care topic and not coming to an ICU near you anytime soon… #foamcc #foamed

Airway assistant (ala airway ally) litfl.com/airway-assis... the forgotten role in airway management in ED, ICU, and the wards… but an important one! #foamed #foamcc

Unrecognised esophageal intubation litfl.com/unrecognised... Largely derived from the superb PUMA guidelines by @chrimesy.com et al #foamed #foamcc

Metaraminol litfl.com/metaraminol/ A very commonly used drug in UK/ ANZ crit care - but one there is surprisingly little known about… #foamed #foamcc

Semaglutide litfl.com/semaglutide/ Not a core ICU drug but we need know about GLP1R agonists! #foamed #foamcc

Continuous beta-lactam infusions litfl.com/continuous-b... Is this the way to “make antibiotics great again”? #foamed #foamcc

“On Not Betraying Our Trainees, Especially Now” I won an Extraordinary Achievement Award from the Critical Care Assembly last month The @atscommunity.bsky.social premier journal @atsblueeditor.bsky.social TODAY published the remarks I made on that occasion www.atsjournals.org/doi/10.1164/...

The second trial result for #CCR25 in Titanic Belfast in June is GASTROSAM Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition Join us in June for the best critical care trials in the world Register at criticalcarereviews.com/meetings/ccr25

The third trial result for #CCR25 in Titanic Belfast in June is the UK-Rox Trial Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU Register via the QR code or on the CCR website criticalcarereviews.com/meetings/ccr25

The fourth trial result for #CCR25 in Titanic Belfast in June is FLUID Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients Register at https://criticalcarereviews.com/meetings/ccr25

The fourth trial result for #CCR25 in Titanic Belfast in June is FLUID Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients Register at criticalcarereviews.com/meetings/ccr25 Critical Care Reviews Meeting 2025 The Best Critical Care trials in the World

The fifth trial result for #CCR25 in Titanic Belfast in June is NOTACS Nasal High-Flow Oxygen Therapy after Cardiac Surgery Register at criticalcarereviews.com/meetings/ccr25 Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World

The sixth trial result for #CCR25 in Titanic Belfast in June is PROMIZING Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Register at criticalcarereviews.com/meetings/ccr25

The 7th presentation at #CCR25 is the TTM2 biomarker results Biomarkers of Brain Injury after Cardiac Arrest Register via the QR code or on the CCR website Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World

Delighted to announce the 8th trial results presentation for #CCR25 - ENCOMPASS. Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship Register via the QR code or on the CCR website #CCR25 - The Best Critical Care trials in the World

The ninth trial result for #CCR25 in Titanic Belfast in June is INdex CT-perfusion for the Neurological Determination of Death Investigators - Michaël Chassé & Jai Shankar Register at https://criticalcarereviews.com/meetings/ccr25

The 10th presentation at #CCR25 is RESCUE 3 Temporary Transvenous Diaphragm Pacing vs Standard of Care for Weaning From Mechanical Ventilation Register via the QR code or on the CCR website Critical Care Reviews Meeting 2025 The Best Critical Care Trials in the World

🚨 Coming Soon at #CCR25 🚨 The #TTM2 Biomarker Study results! Fresh insights into neuroprognostication after cardiac arrest 🧠 How will this impact clinical practice? ➡️editorial & expert discussion 📺 Free livestream — but it’s better in person! 🔗 criticalcarereviews.com/meetings/ccr25

🚨 NOTACS TRIAL Results at #CCR25 🚨 📍 18 🇬🇧🇦🇺🇳🇿hospitals 👥 Up to 1,280 pts 🎯 High-flow nasal therapy vs standard oxygen after cardiac surgery 🩺 Days alive & at home by D90 🤔 Can HFNT enhance recovery after heart surgery? 📺 Free livestream! 🔗 criticalcarereviews.com/meetings/ccr25

#CCR25 … here we go! Three days of deep discussion of the top trials in critical care. If you are not in the room, do connect via livestream - see criticalcarereviews.com