🧵 The Cosmic Microwave Background (CMB) is like a snapshot of the newborn universe, taken 380,000 years after the Big Bang. It is a key piece of evidence for the standard cosmological model (ΛCDM), but a new study suggests that part of this signal... ➡️ uni-bonn.de/en/news/087-... 🔭 🧪 #cosmology

#Fumarate update Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation Dual role in Inflammation Anti- KEAP1-NRF2 GSDMD NLRP3 IL-10 Pro- mtDNA mtRNA➡️IFNβ #CellMetab 2025 www.sciencedirect.com/science/arti...

Best lab assessment for coronary artery risk consists of ApoB particles and LP(a) academic.oup.com/eurheartj/ad...

Improving #mitochondria associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and #cancer www.sciencedirect.com/science/arti...

"The vaccine provides close to 100% protection against infections and pre-cancers caused by certain types of HPV. That is remarkable." Effective cancer prevention. www.voicesforvaccines.org/hpv-vaccine-...

“Science is not left or right. It’s reality.” 🧵🧪

We've greatly underestimated the role of the gut microbiome in fatty liver disease (MASLD). This open-access outstanding review @jclinical-invest.bsky.social is illuminating www.jci.org/articles/vie...

Molecular mechanism of #melatonin -mediated #mitophagy regulating proline production to ameliorate skin #aging 👇 www.sciencedirect.com/science/arti...

SIRT2 alleviates pre-eclampsia via prompting mitochondrial biogenesis and function. www.sciencedirect.com/science/arti...

90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.

Supercharged T-Cells Hunt Down the Hardest-to-Treat Cancers scitechdaily.com/supercharged...

•SIRT3 deficiency exacerbated the progression of DED. •SIRT3 plays a significantly protective role in DED by enhancing autophagy. •The deacetylation and subsequent nuclear translocation of FOXO1 are mechanisms through which SIRT3 regulates autophagy in DED. www.sciencedirect.com/science/arti...

•CPP can delay D-gal-induced liver aging •CPP can alleviate structural damage and functional impairment in aging liver & mitochondria •CPP can improve mitochondrial energy metabolism in aging liver of mice by regulating cAMP signaling pathway & other mechanisms www.sciencedirect.com/science/arti...

Mechanism and application prospect of #magnesium -based materials in #cancer treatment www.sciencedirect.com/science/arti...

#Mitochondrial dysfunction is a central hallmark of #aging and #energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity. www.cell.com/trends/bioch...

The critical role of mitochondrial dysfunction in ADT-induced neurotoxicity www.nature.com/articles/s41...

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures www.nature.com/articles/s41...

Resveratrol protects neonatal rats from hyperoxia-induced kidney injury by promoting mitochondrial biogenesis, possibly in part through activation of the SIRT1/PGC-1α signaling pathway. www.sciencedirect.com/science/arti...

Suddenly, out of nowhere, a declassified World War II-era CIA guide to sabotaging fascism in the workplace has become one of the most popular free ebooks on the internet: www.404media.co/declassified...

The situation keeps worsening. A single outbreak in Arizona has led to the loss of 316,000 egg-laying chickens. Bird flu is spreading faster than it can be contained.

Caroline Kennedy, cousin to the current pick for HHS secretary Robert F Kennedy Jr, has penned a scathing letter warning senators about her cousin, calling him a "predator." She also says her father and uncle would be "disgusted" by RFK, Jr. www.youtube.com/watch?v=YLLx...

How about those Buckeyes? What a game! #Buckeyes #GoBucks #CaptainJack #JackSawyer

In 1979, Jimmy Carter installed solar panels on the White House. In 1986, Ronald Reagan tore them down along w/Carter’s clean energy funding. This sums up the difference between the two men & political parties. Investing in solutions for the future vs canceling progress to score political points.

The Russian disinformation network “Matryoshka” has launched a new campaign on Bluesky. Eliot Higgins, founder of the investigative journalism group Bellingcat, has been one of the first researchers to detect its activity. So far, four Russian-made fake videos have been identified on the platform.

In news that surprises no scientist in cancer research, alcohol is linked to several cancers. Alcohol has one of the strongest links to increased cancer risk of any modifiable risk factors. I wrote about cancer basics here, including modifiable risk factors: news.immunologic.org/p/cancer-hun...

This study highlights the significance of nanoengineered mitochondria as a promising and feasible tool for the replacement of dysfunctional mitochondria and the repair of mitochondrial function in mitochondrial disease therapies. www.sciencedirect.com/science/arti...

THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️

Mitochondrial-derived microproteins: from discovery to function www.cell.com/trends/genet...

What a year! Bluesky opened its doors just last February. Since then, we opened federation, launched video, rolled out trending topics, and a whole lot more. Happy New Year, and here’s to a great year ahead! 🎉

Heading off to bed, in case no one has told you this yet today- you are enough exactly as you are. Sweet Dreams.

A soul saved.

The Holidays and Hoops. Nothing better…

#AT40 You don't have to love Boston the way I do, but if you can't accept that this song is pretty much perfect* than you have a damaged soul. *Also better than most Led Zep songs

This is a devastating article highlighting the contortions in logic (and humanity) that our manufacturing and legal system will go through to achieve efficiencies that will only serve to make the very rich very much richer.

Goldman Sachs analysts : The money men saying the quiet part out loud Curing patients may not be a sufficiently profitable enterprise for biotech companies. Chronic disease is a far more beneficial business model www.cnbc.com/2018/04/11/g...

“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging www.nature.com/articles/s41...

- Come listen to me yap about #Mitochondria 😂 ⚛️🧬 And stay for the other amazing talks/discussions on how to stabilize Healthspan with aging 🫡🔥 #Aging #HealthSpan #Immunology #Cardiovascular

Here's something to consider - have a great one everyone! #aging #longevity #retirement #exercise #health #motivation #inspiration

And in-depth on the Idiot of the Year from Aaron Rupar, who we all should support since we’re off cable news. www.publicnotice.co/p/trump-time...

Some folks are pretty good seeing things coming.

This needs to be taken very seriously. All donations that originate from abroad, no matter who is the final donor, should be banned. Only UK citizens should be allowed to donate to British political organisations

💯💯

Neuschwanstein Castle, Germany

If you would like to teach your students useful data skills, the entire PsyTeachR suite is available with a creative commons licence to reuse and adapt. We teach stats but our focus is on working with real data, wrangling, visualisation and reproducibility using R psyteachr.github.io #AcademicSky

Excellent piece from my buddy Paul Kiel on an obscure loophole that allows billionaires to avoid Medicare tax: www.propublica.org/article/medi...

It Is Not Just About Storing #Energy: The Multifaceted Role of #Creatine #Metabolism on #Cancer Biology and Immunology www.mdpi.com/3081778

A little louder for the folks in the back: The development of vaccines is likely the greatest achievement of mankind. www.washingtonpost.com/wellness/202...