The last paddle board of the season. 🍁🇨🇭

Phil and Penny Knight announced today a record-breaking $2 billion gift to the Oregon Health & Science University’s Knight Cancer Institute to transform the future of cancer care and set a new standard globally. Thank you to Phil and Penny Knight for their incredible generosity. #GiveCancerHell

🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators! 📄 www.nature.com/articles/s41... #SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social

And wonderful photos by our in-house photographers/ drone specialists 📷👏 @drspencerwatson.bsky.social @dolfibastien.bsky.social 🙏 This group photo was captured by drone - a J for Joyce lab 😉 My thanks again to ~50 alumni & current lab members who joined over the 3 days of this truly unique event!!

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma! doi.org/10.1093/neuo...

Thank you @naturemethods.bsky.social for highlighting our recent paper on "Spatial Mechano-Transcriptomics" in your April Issue: www.nature.com/articles/s41... www.nature.com/articles/s41...

Thrilled to announce our doctoral network for spatial oncology as been funded by Marie Skłodowska-Curie Actions! This combines some of the best immuno-oncology and computational labs across Europe to create a multi-disciplinary PhD program for spatial-omics cancer research. More details soon!

Please also check out the News & Views highlighting this cool work! www.nature.com/articles/s41...

What's better than spatial metabolomics? Spatial metabolomics in 3D! New from Ramon Sun and colleagues, a 3D map of the brain metabolome using AI, with an interactive database to explore. www.nature.com/articles/s42...

Morning in Haute-Nendaz 🇨🇭

OMG, I feel so seen!

Also, what’s this big orange thing in the sky over London? Never seen that here before.

Fantastic scientific advisory board meeting for @braintumourcharity.bsky.social Some great applications I’m excited to see funded. Thanks again for everything the Charity does to support cutting edge brain cancer research!

Check out this amazing visualization of SNSF funding by Colas Droin! Really highlights how Switzerland has become such a scientific leader through intelligent investments in research. colasdroin.github.io/snsf-dataviz/

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

Evening in Lutry Switzerland

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

Exciting to see these approaches reach clinical trials.

It’s great to see these progressive changes by @ethzurich.bsky.social. It’s hard enough getting and starting an assistant professorship, removing barriers will be a huge gain for early career scientists and academic research in Switzerland. #EduSky #AcademicSky

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com www.nature.com/articles/s41...

I’m at the AI Moonshot Hackathon for glioblastoma in Paris, put on by Owkin and Servier. We have 15 teams working with spatial transcriptimics to develop new analyses for GBM. Excited to see what they come up with. #ScienceSky #CanSky #MedSky

In Paris today speaking at the Brain Tumor Microenvironment Symposium. It’s a very impressive lineup, really looking forward to it. It’s also my first time in Paris so would love some recommendations on what to do after the symposium. #CanSky #ScienceSky #MedSky curamus-cancer.fr/wp-content/u...

Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

In London to speak at the British Neuropathological Society symposium. We'll be discussing how we can apply spatial-omics approaches to improve immunotherapies for glioblastoma patients. #CanSky #ScienceSky #MedSky www.bns.org.uk/126th-bns-me...

Deleted all FB/Insta/Meta accounts. Now I don’t have anywhere else to post cute pet pics. So for now on I’ll be posting about cutting edge cancer research, and random stuff my dog does. #ScienceSky #CanSky #AcademicSky

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

Making space for spatial biology in the clinic Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz

You cannot underestimate all the positive and long-term benefits of having a supportive #mentor One could argue this is at least as important as the research topic 🧪 Do choose wisely.. #MentoringMonth

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

Spatial Proteomics is the Method of the Year 🧪 from Nature Methods! Resharing our #HIFI paper - which we developed to be #accessible and #economical for all interested in #spatial analysis of complex tissues @drspencerwatson.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

Great to see spatial proteomics named as the Method of the Year. Couldn't agree more! www.nature.com/articles/s41...

#Emotional #Distress Signature in #cancer patients associated with lower RR to IO - Blocking #Adrenalin Receptor improves outcome in mice! Humans? Consistent with reduced immunity, Distressed pts have less SAEs / Prof Christian Blank @nkinl.bsky.social #Bridge2024 @sitcancer.bsky.social #psychology

Great first day of TMEsystems24 at Georg-Speyer-Haus. Got to give a talk in the same session as my PhD mentor Joe Gray, and see a museum of the world’s first cancer research lab. #cancer #science

Developed by my brilliant PhD student, Eloise Withnell, we use SpottedPy to explore EMT plasticity in breast primary tumours and uncover a hybrid, quasi-mesenchymal E/M state linked with immune evasion. #cancer #spatialtranscriptomics #EMT

Looking at how the surrounding brain's response to surgical tumor resection can help cancer cells survive treatment. We saw saw similar pro-survival niches following immunotherapy treatment in the lab of @johannajoyce.bsky.social. www.cell.com/cancer-cell/...

Hello Bluesky! Glad to see so many familiar faces here. #science #cancerresearch #sciart