#NatMicroPicks bacterial amino acid metabolism affects cancer progression 🦠🦀🐁 Bacteroides asparaginase lowers intestinal asparagine levels and drives colorectal tumor progression #MicroSky www.cell.com/cell-host-mi...

A study published in Nature Communications reveals that exposure to certain food preservatives, including potassium sorbate and sodium nitrite, correlates with a higher risk of developing type 2 diabetes. 🧪

Beyond #weightloss How might GLP-1 medicines modify rates of #obesity associated #cancer and response to treatment? www.nature.com/articles/s43...

Nature Health launches today! In our inaugural editorial, we outline our vision of 'health beyond medicine' and aim to publish research, reviews and opinion that bridges the 'implementation gap' between health research with policy and practice. www.nature.com/articles/s44...

Online now: Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin availability at night

Online now: Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

RESEARCH | L Casanueva Reimon, SM Steculorum et al. (CECAD) Non-nutritive sensory components of high-fat diet, such as bacon flavor, are sufficient to impair metabolic health in mice 🧪

Variation in the GLP2R and the risk of chronic metabolic disorders @uk_biobank #genetics www.metabolismjournal.com/article/S002...

A study published in Nature Medicine demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings. 🧪

It turns out that high-intensity interval training whether once or 3x weekly over 16 weeks reduces fat mass in adults with overweight and central #obesity #exercise www.nature.com/articles/s41...

Gut molecule shows remarkable anti-diabetes power An international group of scientists led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS, along with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof.…

#NewResearch Gut microbes can produce ethanol and contribute to auto-brewery syndrome. FMT can potentially treat individuals with this syndrome and improve symptoms. #microsky www.nature.com/articles/s41...

Congratulations to @microbesity.bsky.social on the publication of his new study on Dysosmobacter welbionis, and thanks to Patrice for letting me play a small part in it. Nice start to the new year. :) #microbiomesky

Thank you Lesley for your help and collaboration ! #ingutwetrust @bugsinyourguts.bsky.social

Patrice Cani (WEL Research Institute – UCLouvain) et ses collaborateurs internationaux ont identifié un composé, le TMA, produit par les bactéries intestinales à partir de la choline présente dans certains aliments, capable d’améliorer le contrôle de la glycémie. welri.org/cms/c_205381...

🧬 Free @microbesng.bsky.social PopUp ECR symposium 🧬 UK-based MRes or PhD student, research assistant or postdoc working on microbial genomics or metagenomics? Present your work and/or chair a session, plus excellent keynote speakers: @halllab.bsky.social and @alexmsalmeida.bsky.social. #MNGPopUp

A new review @jclinicalinvest illustrates the critical nature of gut-brain communication in human disease and the potential to target gut-brain pathways for therapeutic benefit www.jci.org/articles/vie...

#Throwback 🧪 METABOLIC MESSENGERS | Itaconate ‪@lukeanthonyoneill.bsky.social‬ et al https://bit.ly/44QMCWj#Throwback"

Reviews/Perspectives Top #Citations 2025: 🥉🧪 M Van Hul, P Cani @microbesity.bsky.social#Citations(UC Louvain) et al. The gut microbiome and cancer: from tumorigenesis to therapy

Online now: Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

#Throwback 🧪 COMMENT | Big data and personalized nutrition: the key evidence gaps N Guess

#Throwback 🧪 REVIEW | Obesity-induced inflammation: connecting the periphery to the brain O Le Thuc & C García-Cáceres

#Throwback 🧪 PERSPECTIVE | Emerging tools and best practices for studying gut microbial community metabolism ‪@cecilianoecker.bsky.social‬ & P Turnbaugh

After an exhausting few days, now back at home, Santa catches up on new data for GLP-1 medicines, and one of his personal interests, Age-related macular degeneration and #weightloss therapies. Santa (almost) never gets tired of TriNetX data www.sciencedirect.com/science/arti...

#Throwback 🧪 REVIEW | Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities A Yurdagul et al.

Top #Altmetric 2025: 5️⃣🧪 MP Snyder et al ( @stanfordmedicine.bsky.social#Altmetric) show that the SCFAs propionate and butyrate have differential effects on chromatin remodelling, contributing to selective histone acylation.

#Throwback 🧪 REVIEW | NAD+ precursor supplementation in human ageing: clinical evidence and challenges @rhhoutkooper.bsky.social#Throwback K Vinten et al.

Important new, large (N>28,000 women) randomized clinical trial of breast cancer screening: age-based vs risk-based by polygenic risk score, genomics "opportunity to modernize screening" jamanetwork.com/journals/jam...

FREE to read this month REVIEW | Human genetics of steatotic liver disease @stefano-romeo.bsky.social , R Mancina, L Valenti

A Review in Nature Reviews Endocrinology discusses the epidemiological evidence for weight changes in thyroid dysfunction, the role of thyroid hormone in weight regulation, the effect of treatment and the implications for population health. go.nature.com/48r4bhU 🔒

RESEARCH | L Shen, W Zhu, L Qin, M Lu et al (Fudan U, CAS; CN) 🧪 Acetate accumulation and metastasis of hepatocarcinoma cells is driven by a metabolic interaction involving HCC-derived lactate and acetate secretion from tumour-associated macrophages www.nature.com/articles/s42...

Mouse studies highlight the therapeutic potential of existing and emerging strategies to manipulate the bile acid pool and to regulate dietary fat absorption across a spectrum of conditions—from malabsorptive disorders to cardiometabolic diseases www.cell.com/cell-metabol...

Delighted to see this paper out with @mrjulien.bsky.social and @marcedumas.bsky.social. It's taken a lot of work/time to get this over the line, and adds to what we know about how microbe-derived metabolites - in this case TMA - influence host-associated processes. www.nature.com/articles/s42...

Fecal microbiota transplantation unable to induce remission at 8 weeks in adults with Crohn’s disease Karen Madsen reports the latest negative findings of a clinical trial: https://loom.ly/QvPtXoI

New from The Tomas Lab Key pathways linking GLP-1R signaling to regulate β-cell mitochondrial remodelling and function #islets #diabetes www.nature.com/articles/s41... @tomaslab-imperial.bsky.social

Online now: Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade

The progress in GLP-1 medicines for #obesity was not easily predicted. In 1998 @ScienceMagazine ran a series on Regulation of Body Weight, informed by advances in mouse and human #genetics Understandably, little attention to the GLP-1 pathway at that time #weightloss www.science.org/doi/10.1126/...

The microbial metabolite TMA for the metabolic win #insulin resistance #obesity via inhibition of IRAK4 in mice #microbiome www.nature.com/articles/s42... 🧪

Back in 2007, we found that high-fat diets allowed bacterial components to leak into the blood and trigger inflammation leading to insulin resistance. It sounded far-fetched. Today it’s widely accepted. In 2025, we uncover with @marcedumas.bsky.social how to switch off that inflammation loop.

Our study, now out in Nature Metabolism: 🔥 Microbial trimethylamine inhibits IRAK4, a key kinase in inflammation ➡ This blunts TLR-driven inflammation and decouples metabolic dysfunction from obesity ✅ This casts IRAK4 as a therapeutic target for metabolic diseases. Meet TMA, our unexpected hero ⬇️

Sa 13/12 à 10h15. Séance du Président consacrée à l'endomètre, l' #endométriose et l' #adénomyose avec les exposés de Jan Brosens Univ. of #Warwick, Hilary Critchley & Philippa Saunders @edinburgh-uni.bsky.social & Marie-Madeleine Dolmans UCLouvain 👩‍🔬 #Medsky #Ob/Gyn - mailchi.mp/308f711a896d...

How do we acquire and share our microbes throughout life — and why does it matter for human and planetary health? In this new GMFH interview, Dr. Mireia Vallès-Colomer explores microbial transmission, the One Health perspective, and the future of microbiome science. https://loom.ly/D_S96cE

The number of children and adults diagnosed with ADHD is increasing in some countries. A feature in Nature details how science is helping to understand why and how best to provide support. #medsky 🧪

The outsized role of our brain astrocytes nature.com/articles/d41...