Mechanistic insights into the therapeutic properties of delta opioid receptor | Science Advances www.science.org/doi/10.1126/...

New Paper: Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions Main point: psychedelic-therapy is not more effective than open-label SSRIs/SNRIs Study also highlights the influence of blinding integrity jamanetwork.com/journals/jam...

This review proposes using PET imaging to study how menstrual cycle-related ovarian hormone fluctuations and associated neurotransmitter changes drive psychiatric symptoms, particularly in conditions like PMDD and ADHD, to advance precision medicine.

New PET study links baseline AMPA receptor distribution and post-ketamine regional changes to antidepressant response. www.nature.com/articles/s41...

This study examined mGluR5 availability in individuals with & without chronic pain across psychiatric diagnoses; ⬇️ availability was associated with ⬆️ depression, anxiety, & executive dysfunction, highlighting mGluR5 as a potential treatment target

Phase 3 effect of COMPASS (3.6 point decrease) half the size of the prior effect? And they changed the definition of response from 50% decrease (which is industry standard) to 25%? The effects are significant. Are they clinically meaningful? (6-9 point drop) psychedelicalpha.com/news/compass...

lets talk about sex

Small early-phase, randomized placebo-controlled IV DMT study reports rapid reductions in depression scores vs placebo. Interesting signal, but interpret with the usual psychedelic-trial caveats (functional unblinding, small N, wide CIs) www.nature.com/articles/s41...

Our paper with @vyazovskiy.bsky.social showcasing research conducted at @ox.ac.uk @oxforddpag.bsky.social is out! We describe the effects of the psychedelic 5-MeO-DMT on brain states and sleep via EEG, LFP & freely moving oculometry. Read more: www.nature.com/articles/s42... #EEG #neuroskyence

Has the 🇺🇲 just lost the "non-psychedelic psychedelic" science throne to 🇨🇳 ? 🧪🧠📈 Is there any future left for medical tripping? Hard Qs to ponder over the year... www.nature.com/articles/s41...

Been waiting for such a study to relate #psilocybin dose to 5-HT2AR occupancy in the mouse brain. They found RO₅₀ = 0.88 mg/kg. journals.sagepub.com/doi/10.1177/...

New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice. www.nature.com/articles/s41...

🐁 Very concerning finding: Psilocybin promotes brain tumour growth Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed." Extends to other serotonergic drugs like LSD.

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

A new PNAS paper finds that polarization increased immediately after the invention of smartphones and the advent of social media, which both appeared around the same year, 2008. www.pnas.org/doi/10.1073/...

New study out today in Nature Comms: www.nature.com/articles/s41..., in which we set out to test whether ultrasound could influence the reward-related learning computations of the nucleus accumbens, building on decades of work on dopaminergic prediction error and reinforcement learning. And it did.

My dissertation paper finally dropped in Nature Communications! Overall, the conclusion is that psilocybin may be useful in reducing drug craving that often precipitates relapse through mechanisms related to 5-HT2A activation. www.nature.com/articles/s41...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

New paper in Nature Neuro, with very impressive results (in mice): Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain www.nature.com/articles/s41...

Considering the phase 2 LSD for anxiety study has been published and is in the news a bit right now, here's a piece from last year where I spoke to the CMO of MindMed about the trial's somewhat unique protocol. Bit more detail here about how the dose sessions worked than in the actual study.

Neat- Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses www.pnas.org/doi/10.1073/...

Does #ketamine work via opioid system? This controversial idea finds new support in a randomized trial, where the opioid blocker naltrexone impeded ketamine's #antidepressant and glutamatergic effects: www.ncbi.nlm.nih.gov/pubmed/40707... #depression #psychiatry #pmhnp

The emotional architecture of the psychedelic brain: If you are interested in #psychedelics and #emotions, take a look at our new paper: authors.elsevier.com/sd/article/S.... With Flora Moujaes, @nathalierieser.bsky.social, Lydia Belinger, Marcus Herdener, & Zarmeen Zahid. Just published in TICS.

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...