To the #XchromosomeInactivation field: anyone knows Xist is a long #noncodingRNA Which publication has ruled out that there are protein coding regions within it? And how?

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

The story of sex determination from a woman’s life perspective. Beautiful thread for #WomenInternationalDay

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

A #computational #Postdoc position is available in my lab to dive into #chromatin mediated #epigenetic mechanisms underlying #autoimmune reactions in #MultipleSclerosis! Please circulate

FUNDED! I will be recruiting soon a computational #postdoc. If you fancy working on exceptional #singlecell #omics datasets to explore the role of #XChromosomeInactivation in the #sexdifferences of #autoimmune diseases contact me! Predoc fellows with prior experience are also invited to apply!

Happy #womenInSTEM day!

Our university has hoghlighted our recent work on #Treg and breast #cancer. Italian only www.unina.it/-/66774917-l...

Get in touch if you are passionate for science and want to learn more about #epigenetic of sex differences in human disease www.embo.org/funding/fell...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Our first #immunology paper is out! We show that Tregs with FOXP3 splicing variants retaining exon 2 are a prognostic marker for breast cancer www.science.org/doi/10.1126/...

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

🚨🚨🚨 Call is now open!!! Deadline approaching... Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities APPLY 👇👇👇👇👇

Only two days left to apply for a PhD studentship in my group and the group of @alexisbarr.bsky.social . Please share! www.findaphd.com/phds/project...

🎯Spotlight by @ProfJennyGraves on imprinting of the paternal marsupial X chromosome by DNA methylation 👉https://sciencedirect.com/science/article/pii/S0168952524002622 highlighting our recent paper on X chromosome inactivation in marsupials 👉https://www.pnas.org/doi/abs/10.1073/pnas.2412185121

🎉Excited to share our new preprint on Biorxiv 🥳 We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress! So what did we find? 🧵 www.biorxiv.org/content/10.1...

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination www.science.org/doi/10.1126/...

Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

#Clinical #epigenetic #conference

We did it! We biorxived a manuscript!!! First from my lab in which we show that a subset of #Treg expressing a splicing variant of #FOXP3 differing for 105bp exon are enriched in #breastcancer tumors with worse prognosis related with immune suppressive capacity www.biorxiv.org/content/10.1...

I must be producing a lot of em on grant deadline … ?

Funny annecdote about the publication of Darwin's "On the origin of species". Over 150 years later it feels like peer-review didn't change all that much. www.nytimes.com/2024/06/09/b...

Looking for 1 year Postdoc in #chromatin regulation of #transcription for #XChromosomeInactivation study in human #iPSC/lymmphocytes (collaborative project!) wet lab/hybrid. Candidate needing #VISA might be supported only if competitive for #fellowships. Start:October 2024

may the 4th be with you!!

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

A #milestone paper: the #female #sex determination gene discovered! Three aminoacid change in #WT1 shut down Sry and determine development of #ovaries. www.science.org/doi/10.1126/... @ScienceMagazine

Anyone can suggest a #kit for #total #RNA extraction from low cell numbers (20-100k) which performs better than the manual #guanidine protocols? No #Quiagen #Micro!!!

Anyone has a good couple of #primers recognising human #ribosomal #RNA?

We are opening a second position for a computational pre/post doctoral fellow to investigate #epigenetics of #sexbias in #autoimmunity in a highly interdisciplinary team. Start date:Jan 2024.

I am looking for wet and dry lab postdocs who want to join my group to study epigenetic determinants of sex bias in autoimmunity. Please spread the word.