For the first time, we can see individual mRNAs in 3D inside cells at nm precision. Their shapes vary by gene and subcellular location. Congrats @fbzt.bsky.social & team @impvienna.bsky.social Top 1% @qedscience.bsky.social Edited by @lifescienceeditors.bsky.social www.biorxiv.org/content/10.6...

For the second time this month, a team of researchers has reported harnessing a precise gene-editing technique to alter the DNA of human embryos go.nature.com/4vwIXrO

#postdoc #fellowship available in my lab (1year renewable) to investigate #chromatin mediated #epigenetic mechanisms of #sexbias in #autoimmunity and the role of long #mcRNA #XIST. Please RT!

📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption authors.elsevier.com/a/1m%7EU03vV... or www.cell.com/molecular-ce...

This a very important, and extremely well-executed study from Ralph Grand’s group @uniheidelberg.bsky.social. Congrats to all the authors! www.biorxiv.org/content/10.6...

Excited to share our first story led by @martinacapriati.bsky.social! How do cells control the expression of viability genes? We find that single transcription factors can drive both chromatin opening and gene activation from densely co-bound CpG island promoters, including at essential genes

A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to. spklr.io/63324EJmf0

Our paper on the evolution of XIST regulatory network in primates is now published in Science Advances! Check out the paper www.science.org/doi/10.1126/... or a digest of our findings emmanuelczt.github.io/posts/2026/0... A short 🧵 of our main findings 👇

Last few days to apply for this #PhD project!

Australia recorded ZERO cases of cervical cancer in women under 25 for the first time since they started tracking the cancer in the 80s. This is the power of vaccines. The HPV vaccine is extremely effective at preventing cancer. Viruses can be oncogenic. Get your vaccines and protect yourself!

🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏

Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!

Advice needed: can you distinguish splicing variants by commercial #spatialtranscriptomic (eg visium)? #singlecell #omics

The #Nobel prize has been assigned to the discovery of #Treg peripheral tolerance. We are humbly greatful for this discovery as we recently described a subtype of Tregs associated with worse breast cancer prognosis

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

How does a “universal” transcription factor evolve to do species-specific jobs? Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes. Read it here 👉 www.biorxiv.org/content/10.1... #MolecularEvolution #Transcription

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

Very excited to share our very exciting story on how misinherited chromatin affects individual cells to cause a behavior defect in C. elegans (a thread👇) www.pnas.org/doi/10.1073/...

#Xcromosome paper on the role of the #human specific long noncoding RNA #XACT!

Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression https://www.biorxiv.org/content/10.1101/2025.10.02.680155v1

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

❓Can a father’s environmental exposures before conception influence their offspring? We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences www.embopress.org/doi/full/10....

Metabolism changes the epigenome across generations via lysosome Supercool! www.science.org/doi/10.1126/...

To the #XchromosomeInactivation field: anyone knows Xist is a long #noncodingRNA Which publication has ruled out that there are protein coding regions within it? And how?

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

The story of sex determination from a woman’s life perspective. Beautiful thread for #WomenInternationalDay

One of the most powerful moments of the day came from Emily Whitehead who told the story of how she was the first pediatric patient to receive CAR T-cell therapy for her leukemia at age 5: “I stand up for science because science saved my life. And that’s a fact.” @standupforscience.bsky.social

A #computational #Postdoc position is available in my lab to dive into #chromatin mediated #epigenetic mechanisms underlying #autoimmune reactions in #MultipleSclerosis! Please circulate

FUNDED! I will be recruiting soon a computational #postdoc. If you fancy working on exceptional #singlecell #omics datasets to explore the role of #XChromosomeInactivation in the #sexdifferences of #autoimmune diseases contact me! Predoc fellows with prior experience are also invited to apply!

Happy #womenInSTEM day!

Our university has hoghlighted our recent work on #Treg and breast #cancer. Italian only www.unina.it/-/66774917-l...

Get in touch if you are passionate for science and want to learn more about #epigenetic of sex differences in human disease www.embo.org/funding/fell...

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Our first #immunology paper is out! We show that Tregs with FOXP3 splicing variants retaining exon 2 are a prognostic marker for breast cancer www.science.org/doi/10.1126/...

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

🚨🚨🚨 Call is now open!!! Deadline approaching... Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities APPLY 👇👇👇👇👇

Only two days left to apply for a PhD studentship in my group and the group of @alexisbarr.bsky.social . Please share! www.findaphd.com/phds/project...

🎯Spotlight by @ProfJennyGraves on imprinting of the paternal marsupial X chromosome by DNA methylation 👉https://sciencedirect.com/science/article/pii/S0168952524002622 highlighting our recent paper on X chromosome inactivation in marsupials 👉https://www.pnas.org/doi/abs/10.1073/pnas.2412185121

🎉Excited to share our new preprint on Biorxiv 🥳 We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress! So what did we find? 🧵 www.biorxiv.org/content/10.1...

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination www.science.org/doi/10.1126/...

Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

#Clinical #epigenetic #conference

We did it! We biorxived a manuscript!!! First from my lab in which we show that a subset of #Treg expressing a splicing variant of #FOXP3 differing for 105bp exon are enriched in #breastcancer tumors with worse prognosis related with immune suppressive capacity www.biorxiv.org/content/10.1...

I must be producing a lot of em on grant deadline … ?

Funny annecdote about the publication of Darwin's "On the origin of species". Over 150 years later it feels like peer-review didn't change all that much. www.nytimes.com/2024/06/09/b...

Looking for 1 year Postdoc in #chromatin regulation of #transcription for #XChromosomeInactivation study in human #iPSC/lymmphocytes (collaborative project!) wet lab/hybrid. Candidate needing #VISA might be supported only if competitive for #fellowships. Start:October 2024

may the 4th be with you!!

#Postdoc openings: we investigate #chromatin mediated #epigenetic mechanisms underlying #sexdifferences and #sexbias in #human #diseases including #immune and #cancer. If u want to join us, we can help you preparing #HFSP #EMBO #MarieCurie fellowships. DM or email (publications needed!)

A #milestone paper: the #female #sex determination gene discovered! Three aminoacid change in #WT1 shut down Sry and determine development of #ovaries. www.science.org/doi/10.1126/... @ScienceMagazine