Lonnie Wollmuth
@lwollmuth.bsky.social
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Professor. Stony Brook. Ion channels. Synaptic transmission. Membrane physiology. Zebrafish
reposted by
Lonnie Wollmuth
Ingo Greger
7 months ago
Happy about our new paper in Nature
rdcu.be/eukUB
The GluA3 structure provides a framework for understanding this disease-prone glutamate receptor - novel interfaces will provide targets for modulator development
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Lonnie Wollmuth
Andrew Plested
8 months ago
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at
[email protected]
. Fee waivers and bursaries available. ! Please share widely !
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Lonnie Wollmuth
OneNeuro Initiative
10 months ago
Hopkins researchers use cryoEM microscopy to advance understanding of glutamate AMPA receptor action. Article link:
www.oneneurojhu.org/2025/04/02/b...
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Lonnie Wollmuth
Theanne Griffith, PhD 🇧🇧👩🏽🔬🇭🇷
10 months ago
Today!!! Support our trainees!! Register here:
us02web.zoom.us/webinar/regi...
add a skeleton here at some point
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Lonnie Wollmuth
Ed Twomey
10 months ago
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Led by
@anish-mondal07.bsky.social
, published in
@natureportfolio.nature.com
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Lonnie Wollmuth
Angelika Lampert
10 months ago
Nav1.7 structure and severe pain: join our next worldwide sodium channel seminar on March 25th by Goragot Wisedchaisri (Seattle, US) on the “Structural basis for severe pain caused by mutations in Nav1.7”
www.sodiumchannelseminars.org
for link and infos. See you there!
#ionchannel
#WSCS
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Needed a break from the anti-science, anti-NIH administration. Dingle peninsula in Ireland.
10 months ago
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Lonnie Wollmuth
Channels, Receptors & Transporters Subgroup of BPS
about 1 year ago
The Channels, Receptors & Transporters Subgroup of the
@biophysicalsoc.bsky.social
is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from
@willowcoyote.bsky.social
@drcontrexin.bsky.social
@corrylab.bsky.social
and others 👇Thanks to our sponsors!
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Lonnie Wollmuth
Channelomics
about 1 year ago
Direct visualization of electric-field-stimulated ion conduction in a potassium
#ionchannel
- Cell
https://buff.ly/3WfbsLe
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Lonnie Wollmuth
Journal of General Physiology
about 1 year ago
Our January issue is here ✨
https://buff.ly/3DFIr4N
The cover shows agonist-induced
#ionchannel
opening of human NMDA receptors assayed using single channel outside-out patches to detect varied activation delays and failures. From Miaomiao He &
@lwollmuth.bsky.social
(
https://buff.ly/3W6IQ6J
).
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Lonnie Wollmuth
Ingo Greger
about 1 year ago
The Neurobiology Division at the MRC LMB is looking for a new group leader:
www.nature.com/naturecareer...
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Research Group Leader - Neurobiology - LMB 2531 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12832855
Research Group Leader Starting Salary £50,608 - £58,919 per annum for appointment to Senior Investigator Scientist Salary £65,940 - £74,448 per ann...
https://www.nature.com/naturecareers/job/12832855/research-group-leader-neurobiology-lmb-2531/
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Lonnie Wollmuth
Michael Grange
about 1 year ago
There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin! See details here:
opportunities.rfi.ac.uk/vacancy/post...
This work is in collaboration with our partners at MSD and their London Discovery Centre. Please share!
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Lonnie Wollmuth
PlessLab
about 1 year ago
Grateful for having contributed to this work by the Isabelle Baconguis group, who solved eleven (!) new structures of hASIC1a to show that open states require linear transmembrane helices, while desensitized states display a dazzling structural diversity
www.biorxiv.org/content/10.1...
#ionchannels
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reposted by
Lonnie Wollmuth
Angelika Lampert
about 1 year ago
Dear ion channel community - come and join us for an exciting talk by
@corrylab.bsky.social
next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the
#WSCS
!
#ionchannels
#Nav
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A good reason to bring out the brown alcohol. A former UG/MS student in the lab (far left. Now MD/PhD at Albert Einstein) stopped by for random visit. Others made the bad decision to work in my lab. Always fun.
about 1 year ago
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Lonnie Wollmuth
Andrew Plested
about 1 year ago
So receptors with only Glutamine (Q) present are permeable to potassium and sodium about equally well, and they actually prefer calcium. We show this in the preprint, others like
@lwollmuth.bsky.social
have shown this.
dx.doi.org/10.1113/jphy...
12/n
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Voltage and concentration dependence of Ca2+ permeability in recombinant glutamate receptor subtypes
You have to enable JavaScript in your browser's settings in order to use the eReader.
http://dx.doi.org/10.1113/jphysiol.2001.012897
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At McGill visiting Derek. Wonderful science here. Lots of synaptic physiology. Very elegant.
#iglur
.
#ionchannels
about 1 year ago
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Lonnie Wollmuth
Ardem Patapoutian
about 1 year ago
Book rec: Neanderthal Man by 2022
@nobelprize.bsky.social
laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
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Lonnie Wollmuth
Christophe 🔬 L
about 1 year ago
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in
@science.org
. Exciting time for axon scientists!
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Lonnie Wollmuth
Irina Talyzina
about 1 year ago
Happy to share our new review on the structural pharmacology of TRP channels! Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.
www.sciencedirect.com/science/arti...
#ionchannel
#TRPchannel
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Lonnie Wollmuth
Channelomics
about 1 year ago
TRPM8
#ionchannel
mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons | Neurology Genetics More from Waxman! HT
@rohacstibor.bsky.social
https://www.neurology.org/doi/10.1212/NXG.0000000000200206
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Lonnie Wollmuth
Angelika Lampert
about 1 year ago
Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on
www.sodiumchannelseminars.org
. Mark your calendar and join in!
#ionchannels
#WSCS
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Lonnie Wollmuth
MRC Laboratory of Molecular Biology
about 1 year ago
Considering a PhD in molecular biology? There’s still time to apply to join the LMB in October 2024. Applications close on 3rd DEC. Visit our website for more info:
www2.mrc-lmb.cam.ac.uk/students/int...
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reposted by
Lonnie Wollmuth
Dan Jagger
about 1 year ago
One for the Thanksgiving dinner table. 🦃 Faeces and vomit fossils from dinosaurs reveal how the animals evolved to rule Earth. 🦕🧪
www.nature.com/articles/d41...
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Fossilized poo and vomit show how dinosaurs rose to rule Earth
Analysis of 200-million-year-old digested foods reveals how the animals became dominant.
https://www.nature.com/articles/d41586-024-03889-y
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Lonnie Wollmuth
Andrew Plested
about 1 year ago
This is a wonderful paper with a ton of difficult single channel measurements on NMDA receptors in non-equilibrium conditions. Fundamental information, presented without hype and with care.
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#iGluR
#ionchannels
I am a slow learner. Still trying to figure out posts.
doi.org/10.1085/jgp....
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Regulation of NMDAR activation efficiency by environmental factors and subunit composition | Journal of General Physiology | Rockefeller University Press
https://doi.org/10.1085/jgp.202413637
about 1 year ago
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@jgenphysiol.bsky.social
Also the experience at JGP was fantastic. Several reviewers really had incredible suggestions that were very helpful.
about 1 year ago
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Beautiful new work by Miaomiao!! Illustrates various pathways for regulating activation of NMDARs. GluN2B r very inefficient and slow. Something fundamentally distinct between GluN2B and GluN2A.
doi.org/10.1085/jgp....
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Regulation of NMDAR activation efficiency by environmental factors and subunit composition | Journal of General Physiology | Rockefeller University Press
https://doi.org/10.1085/jgp.202413637
about 1 year ago
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Sorry if I posted a photo several times. Am new to BlueSky. Learning
about 1 year ago
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Was just a wedding in brooklynn. Always a beautiful view.
about 1 year ago
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about 1 year ago
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New to BlueSky. Working out the kinks but looking forward to a positive scientific (and maybe baseball) environment.
about 1 year ago
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you reached the end!!
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