Caleb Lareau
@caleblareau.bsky.social
📤 1114
📥 426
📝 60
assistant professor
@mskcancercenter.bsky.social
clareaulab.com
I had an unbelievable first time running the NYC Marathon with
@fredsteammskcc.bsky.social
and
@mskcancercenter.bsky.social
! Shout out to the lab for supporting us!
5 days ago
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We have some BIG PLANS TONIGHT!!! with
@ronanchaligne.bsky.social
@mskcancercenter.bsky.social
8 days ago
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Caleb Lareau
Memorial Sloan Kettering Cancer Center
18 days ago
We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the
@nam.edu
. With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition. Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
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Memorial Sloan Kettering Cancer Center Physician-Scientist Elected to the Prestigious National Academy of Medicine
Omar Abdel-Wahab, MD, Chair of the Molecular Pharmacology Program at Sloan Kettering Institute (SKI); Evnin Family Chair in Molecular Pharmacology and Attending Physician on the Leukemia Service at Me...
https://bit.ly/49ezKw0
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Fred Wellman
21 days ago
Zero arrests. 100,000 people. No violence. This who we are.
add a skeleton here at some point
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#nokings
#nyc
#weareallthefrog
21 days ago
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Jenna Norton
23 days ago
Penn and USC have also rejected the Compact! That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
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Penn, U. of Southern California Reject Trump Compact
The universities follow the Massachusetts Institute of Technology and Brown University in rejecting the Trump administration’s proposal that would require sweeping changes.
https://www.insidehighered.com/news/faculty-issues/academic-freedom/2025/10/16/penn-u-southern-california-reject-trump-compact
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Caleb Lareau
Olivier Simard-Casanova
28 days ago
The data is from April but holy moly
add a skeleton here at some point
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Caleb Lareau
Michele Frison
30 days ago
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
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Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
https://www.science.org/doi/10.1126/science.adr5438
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Caleb Lareau
Jacob Schreiber
about 1 month ago
Now that I'm settled in at
@umasschan.bsky.social
, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians! The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
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Caleb Lareau
Jörg Vogel
about 1 month ago
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA WĂĽrzburg, Bavaria.
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Caleb Lareau
Ryan Flynn
about 1 month ago
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well
www.biorxiv.org/content/10.1...
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DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
https://www.biorxiv.org/content/10.1101/2025.10.05.680464v1
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Caleb Lareau
BK. Titanji
about 1 month ago
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
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Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
https://www.nature.com/articles/s41591-025-03972-5
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Caleb Lareau
Nature
about 1 month ago
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more.
#NobelPrize
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Caleb Lareau
Jenna Norton
about 1 month ago
Great article from
@stephaniemlee.bsky.social
at
@chronicle.com
on the NIH Autism Data Science Initiative (ADSI)
www.chronicle.com/article/what...
ADSI funding went to reputable scientists because and only because dedicated NIH civil servants fought hard to ensure a rigorous, science-based process.
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What It’s Like to Be an Autism Scientist Funded by the Trump Administration
The government is funding respected scholars to study autism’s causes, at a time when experts say it’s also sowing misinformation about the same topic.
https://www.chronicle.com/article/what-its-like-to-be-an-autism-scientist-funded-by-the-trump-administration
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Caleb Lareau
Duncan Kountz
about 1 month ago
Does anyone have a good, reasonably up-to-date review of cryo-EM uses and methodology for (relatively) high-resolution protein structure determination? For someone who doesn't have a cryo-EM background.
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Caleb Lareau
I-75 Scientist
about 1 month ago
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts. Tips on how to search for opportunities & set up a subscription for custom searches here:
grants.nih.gov/news-events/...
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New Tool to Explore NIH Grant Opportunities | Grants & Funding
https://grants.nih.gov/news-events/nih-extramural-nexus-news/2025/09/new-tool-to-explore-nih-grant-opportunities
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Caleb Lareau
Kushal K. Dey
about 1 month ago
Introducing Spacelink, a unified framework for identifying and prioritizing spatially variable gene programs at tissue and cell type resolution and linking them to disease GWAS studies. Led by Hanbyul Lee & Haochen Sun
www.biorxiv.org/content/10.1...
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Caleb Lareau
Leif S. Ludwig
about 2 months ago
🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (
@ms-maren.bsky.social
), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉
www.biorxiv.org/content/10.1...
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Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues
High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...
https://www.biorxiv.org/content/10.1101/2025.09.17.675534v1.full
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Caleb Lareau
Kamil Slowikowski
about 2 months ago
I'd like to announce the medRxiv preprint of our latest work: A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
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Caleb Lareau
derek guy
about 2 months ago
my mom took tylenol when she was pregnant, which made me super focused on menswear and now i have a million followers on twitter
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Caleb Lareau
bioRxiv Genomics
about 2 months ago
Mapping transcriptional responses to cellular perturbation dictionaries with RNA fingerprinting
https://www.biorxiv.org/content/10.1101/2025.09.19.676866v1
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Caleb Lareau
Jesse Engreitz
about 2 months ago
New preprint from our lab! What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells? Find out here:
www.biorxiv.org/content/10.1...
👇 1/
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Caleb Lareau
Nature Methods
about 2 months ago
GPU-accelerated MMseqs2 offers tremendous speedup for homology retrieval, protein structure prediction with ColabFold, and protein structure search with Foldseek.
@martinsteinegger.bsky.social
@milot.bsky.social
@machine.learning.bio
www.nature.com/articles/s41...
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GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
https://www.nature.com/articles/s41592-025-02819-8
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Caleb Lareau
Sanford Burnham Prebys NCI-Designated Cancer Center
about 2 months ago
Today 62 National Cancer Institute (NCI)-Designated Cancer Centers released a statement reinforcing the importance of HPV vaccination. HPV vaccination is safe and protects against six types of cancer – including oropharyngeal, cervical, and anal cancers.
#HPVvaccine
#HPVvax
#EndHPVCancers
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Caleb Lareau
Collins Genomics Lab
about 2 months ago
📢We are hiring! The Collins Genomics Lab
@danafarber.bsky.social
is looking to hire two postdoctoral fellows One in hereditary and early-onset adult cancers:
careers.dana-farber.org/job/12158/po...
1/2đź§µ
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Research Laboratory Job: Postdoctoral Research Fellow - Computational Biologist at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Postdoctoral Research Fellow - Computational Biologist job
https://careers.dana-farber.org/job/12158/postdoctoral-research-fellow-computational-biologist-research-laboratory-us-ma-boston-450-brookline-ave/
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Caleb Lareau
MSKEducation
about 2 months ago
🎉 Congratulations to our 10 MSK Postdoc Slam finalists! 👏 You were all fantastic and it was truly inspiring to learn about the incredible and diverse work happening at
@mskcancercenter.bsky.social
. Our
#MSKPostdocs
gave the judges a real challenge… choosing winners was no easy task! 🤗
#NPAW2025
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Caleb Lareau
Danwei Huangfu
about 2 months ago
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer.
bit.ly/3WUiuo1
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Caleb Lareau
Memorial Sloan Kettering Cancer Center
2 months ago
MSK’s Gerstner Sloan Kettering Graduate School of Biomedical Sciences is now accepting applications for its Cancer Biology and Cancer Engineering
#PhD
programs for the 2026 academic year. Apply below:
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Admission to the PhD Programs
Gerstner Sloan Kettering offers a unique opportunity to train with some of the world’s leading researchers while developing a deep understanding of today’s clinical challenges. We are looking for high...
https://www.sloankettering.edu/gerstner/admissions?utm_source=Bluesky&utm_medium=Organic+Social&utm_term=&utm_content=Image+of+PhD+student&utm_campaign=
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The totality of humanity’s (public) sequencing data is now at your fingertips. This is an absolutely monumental resource for genomics research! Congratulations
@rayanchikhi.bsky.social
@rnalab.bsky.social
on this incredible feat!!!
add a skeleton here at some point
2 months ago
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Caleb Lareau
Rayan Chikhi
2 months ago
Logan rapidly accesses the tapestry of Life’s genetic diversity and can help solve global issues. To tackle the microplastic crisis, we searched Logan for new versions of the 213 known plastic-degrading enzymes. We identified 200+ million homologs 🤯, including new high-efficiency enzymes 🥤🔥
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Caleb Lareau
Rayan Chikhi
2 months ago
🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024...
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Caleb Lareau
Fred Hutch Innovation Lab
2 months ago
Banking fixed samples before sorting improves experiment planning & instrument scheduling. 10x GEM-X DSP-based fixation recommends sorting before fixing cells. We attempted to stain, fix, and freeze cells before sorting & generating GEMs for 5' libraries. SFFS = STAIN FIX FREEZE SORT (1/7)
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Caleb Lareau
Cory Booker
2 months ago
Love thy neighbor.
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Martin Pacesa
2 months ago
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian,
@sokrypton.org
, Bruno and many other amazing lab members and collaborators.
www.nature.com/articles/s41...
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Caleb Lareau
Anshul Kundaje
3 months ago
@jengreitz.bsky.social
l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease. Details below
careersearch.stanford.edu/jobs/computa...
Plz RT
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Liana Lareau
3 months ago
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle.
www.biorxiv.org/content/10.1...
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Protein language models reveal evolutionary constraints on synonymous codon choice
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...
https://www.biorxiv.org/content/10.1101/2025.08.05.668603
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George Bouras
3 months ago
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation
#phagesky
1/n
www.biorxiv.org/content/10.1...
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Protein Structure Informed Bacteriophage Genome Annotation with Phold
Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...
https://www.biorxiv.org/content/10.1101/2025.08.05.668817v1
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Rob Patro
3 months ago
🧬🖥️ I am strongly of the opinion that bioinformatics needs to move away entirely from text-based and "loosely" structured file formats for essentially any type of data. File formats should be binary-first, and designed for *correct* and *efficient* machine parsing 1/3
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Had a blast this weekend at the Badger Trail Races— super ULTRA mega congrats to
@colehoneycutt.bsky.social
and
@paulklauser.bsky.social
on their first 100M finishes!!!! Together, we ran 303.3 miles in under 75 hours, burning 50,000+ calories along the way!
3 months ago
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Caleb Lareau
Max Kozlov
3 months ago
The NIH can’t award ANY grants to outside researchers under new WH restriction, reports
@wsj.com
. The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH. Prelude to rescissions, especially after his comments over the weekend?
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Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
https://www.wsj.com/politics/policy/trump-administration-puts-new-chokehold-on-billions-in-health-research-funding-19660215?st=YWVyJH&reflink=desktopwebshare_permalink
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Klebanoff Lab
4 months ago
🚨Today, in
#NatureCancer
, we show that
#CAR-T
cells and
#CAR-NK
cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers.
rdcu.be/exjEy
.
@mskcancercenter.bsky.social
@parkerici.bsky.social
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CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...
https://rdcu.be/exjEy
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Caleb Lareau
Molecular Instruments, Inc.
4 months ago
We're excited to announce major upgrades to the HCR™ platform! 🧬 HiFi Architecture enables miRNA/siRNA detection with unmatched clarity. 🧪 RTU Dispensers now ship for DISCOVERY ULTRA, enabling scalable, low-variability workflows. Explore the full announcement:
tinyurl.com/39je4x8x
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https://www.businesswire.com/news/home/20250723714279/en/Molecular-Instruments-Continue[…]-miRNAsiRNA-Detection-and-Clinical-Grade-Ready-to-Use-Kits
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Caleb Lareau
Timo RĂĽckert
4 months ago
Must read! Super exciting work and innovative approach.
add a skeleton here at some point
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Excited to share a new preprint from the lab with
@ryandhindsa.bsky.social
!
www.biorxiv.org/content/10.1...
Led by
@sherrynyeo.bsky.social
,
@erinmayc.bsky.social
, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/
4 months ago
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Brittany Trang
4 months ago
NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's
#AlphaFold
to prominence (and a Nobel Prize), as its NIH funding runs out. More
@statnews.com
:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬
#bioML
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AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
https://www.statnews.com/2025/07/21/casp-new-funding-from-alphafold-developer-google-deepmind-after-nih-grant-runs-out/
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Caleb Lareau
Dan of the Year
4 months ago
holy shit lmao
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Caleb Lareau
Eric Topol
4 months ago
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
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Caleb Lareau
Mark D. Levine
4 months ago
There is currently an NWS flash flood warning in effect for all five boroughs of NYC. But no City agency has posted it on this platform. Please help spread the word. “If you live in a basement apartment or low-lying area, be ready to move to higher ground.”
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Caleb Lareau
Nature
4 months ago
A key US Senate committee has indicated that it will reject the huge budget cuts that President Donald Trump proposed for some science agencies, including the US National Science Foundation and NASA.
go.nature.com/40H0XST
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US senators poised to reject Trump’s proposed massive science cuts
Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.
https://go.nature.com/40H0XST
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Caleb Lareau
Nikolai Slavov
4 months ago
Key numbers in cell biology Having a sense of scale helps to think more rigorously and realistically about biological systems.
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