One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22

We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us: martinottlab.com Apply here: web103.reachmee.com/ext/I005/103...

Daily #mtDNA intel: • Mito transfer fuels tumor pyrimidine synthesis 🧬 • mtDNA dsRNA drives aging-associated cognitive decline • Novel 12244G>A variant linked to MELAS phenotype 🔬 📄 Full Dossier | 🎙️ Podcast

New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1. www.biorxiv.org/content/bior...

Daily #mtDNA intel: • dsRNA drives aging-linked cognitive decline 🧬 • EV mtDNA transfer triggers osteoarthritis • ANOMALY pipeline identifies NuMTs in long-read data 🔬 #Bio #Genetics 📄 Full Dossier | 🎙️ Podcast

Daily #mtDNA intel: • Gstk1 inhibits cGAS/STING in septic hearts 🧬 • LL37-mediated mtDNA stress drives rosacea 🔬 • Nanosystems enable mtDNA control for wound repair 📄 Full Dossier | 🎙️ Podcast

Daily #mtDNA intel: • mtDNA inheritance enables lineage tracing 🧬 • LONP1 variants linked to diverse phenotypes • HSP90α/DRP1 axis triggers sepsis brain injury 🔬 #mitochondria 📄 Full Dossier | 🎙️ Podcast

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself. www.science.org/doi/10.1126/...

Daily #mtDNA intel: • RNA G-quadruplexes brake OXPHOS assembly 🧬 • EV-mediated mtDNA transfer drives osteoarthritis • Photoactivatable POLRMT inhibition targets cancer 🔬 #CellBio 📄 Full Dossier | 🎙️ Podcast

All together now 🗣️🗣️ : mitochondrial dynamics are vital *even in plants*! 🗣️🗣️ Fantastic work looking looking at the prime candidate for the mysterious & elusive plant mito fusion factors: MIRO1 The momentum for plant mito dynamics is picking up 💪🏻 www.nature.com/articles/s41...

Daily #mtDNA intel: • Nanosystems modulate mtDNA levels for healing • LONP1 variants linked to diverse phenotypes • MBD5/6 loss impairs respiration via chromatin 🧬 #genetics #biology 📄 Full Dossier | 🎙️ Podcast

To all #mitochondria lovers: Euromit 2026 early-bird registration is coming up!

🧬⚡ Call for abstracts & participants | GRC 2026 ⚡🧬 Together with Vamsi Mootha, I’m chairing the 2026 Gordon Research Conference on Mitochondria & Chloroplasts (July 19 - 24, 2026). We’d love to see your application. Thread 🧵👇

Daily #mtDNA intel: • Ageing drives indel accumulation in energetic tissues • Cytosolic mtDNA triggers NLRP3 in Parkinson's models • ANOMALY pipeline improves NuMT detection 🧬 #genetics 📄 Full Dossier | 🎙️ Podcast

Daily #mtDNA intel: • Molybdenum blocks cGAS-STING in pancreatitis 🔬 • EV-mediated mtDNA transfer drives osteoarthritis • ANOMALY tool detects NuMTs via long-read seq 🧬 #Genetics 📄 Full Dossier | 🎙️ Podcast

#Photosynthesis 🌿: A team led by #LMU biologist Hans-Henning Kunz has now deciphered the chloroplast ionome of various plant species. Their findings form an important basis for elucidating the regulation of mineral homeostasis in chloroplasts & developing new biotech strategies.

Check out our new newsletter!!🎊❤️ Kudos to the newsletter team for their efforts!🎊

Daily #mtDNA intel: • #NanoDel detects large mtDNA deletions via long-read seq 🔬 • Damage markers link to Long COVID cognition • Mito mechanisms central to gentamicin nephrotoxicity. 📄 Full Dossier | 🎙️ Podcast

Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! 😎 (please share) careersearch.stanford.edu/jobs/life-sc...

Daily #mtDNA intel: 🧬 • TFAM modulation suppresses interferon signaling in SSc models. • Astaxanthin targets pyroptosis via cGAS-STING inhibition. • Archaic mtDNA fragments alter nuclear genome function in m... 📄 Full Dossier | 🎙️ Podcast

Daily #mtDNA intel: • Acridine ligand selectively targets mtG4s, triggering cancer apoptosis. • CLIPPER regulates LPIN1 biogenesis for heart regeneration. • BLM helicase inhibition disrupts caprine oocyte ma... 📄 Full Dossier | 🎙️ Podcast

Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠 prelights.biologists.com/highlights/s...

🧬 Introducing the #mtDNA Lab Intel Pipeline! Our system daily scans PubMed and bioRxiv to bring you: 📄 #Gemini generated Daily Dossiers (PDF) and 🎙️ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number 📂 Full Archive: drive.google.com/drive/folder...

Plz read our study by @lmumuenchen.bsky.social PhD cand. Lorenz. He describes chloroplast ionomes for several 🌱species & shows how plastid iron can be massively increased. Terrific help by peers from @ruhr-uni-bochum.de, @mizzouid.bsky.social and @uni-saarland.de academic.oup.com/plcell/artic...

Our new paper is out 🎉 in @narjournal.bsky.social A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast. Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators! academic.oup.com/nar/article/...

How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab. journals.plos.org/plosgenetics... 🧬⚡

🚨 Preprint alert! 🚨 My first first-author manuscript is out on bioRxiv! We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social #mtDNA #mitochondria www.biorxiv.org/content/10.1...

Lost in translation? Chloroplasts can handle slang! New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social‬ @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1

Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance. www.embopress.org/doi/full/10....

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

And here's the thread by @gavsturm.bsky.social explaining their herculean and fascinating work on #pearling #biophysics!

@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ? @felix_thoma on 𝕏 Apr 25, 2022 "Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse" need this here!