PRESS RELEASE! Fantastic research by @panosroussos.bsky.social, Bin Zhang, et al. at the Icahn Mount Sinai shows disruptions in communication between neurons and supporting brain cells called glia are closely linked to the progression of #Alzheimers. Learn More ➡️ www.mountsinai.org/about/newsro...

Study reveals #Alzheimers involves more than plaques & tangles; AD also stems from disrupted communication btwn brain cells. Ricardo D’Oliveira Albanus, Gina Finan, et al. uncover SEMA6D–TREM2 pathway which helps #Microglia clear harmful #Amyloid buildup. Learn More 👉 www.science.org/doi/10.1126/...

CHECK OUT this article in The @washingtonpost.com to find out about the four most common vaccines with the strongest links to reduced risk for #Dementia: The #FluShot, #ShinglesVaccine, #RespiratorySyncytialVirus (RSV) vaccine, and The #TdapVaccine 👉 www.washingtonpost.com/wellness/202...

Findings by researchers Priya Prakash, Palak Manchanda, et al. show that excess fat in the brain’s resident immune cells, #Microglia, impairs their ability to combat disease. @purdueuniversity.bsky.social @clevelandclinic.bsky.social In Immunity @cellpress.bsky.social 👉 www.cell.com/immunity/abs...

MARK YOUR CALENDARS 📅 On 10/8, Council for Responsible Nutrition's 2025 'Science in Session' conference will Dive Into Power of Bioactives for Human Health. I will present "Plant polyphenol metabolites and resilience to stress-induced mood and anxiety". Very exciting! Learn More 👉 www.crnusa.org

A new study by Joaquin Migeot, Stefanie Pina-Escudero, Hernan Hernandez, Agustin Ibanez, et al. reveals that a person's overall social #Exposome is linked to poorer brain health outcomes & increased #Dementia risk. Learn More in Nature Communications 👉 www.nature.com/articles/s41...

Researchers Xiaochun Chen, et al. from Fujian Medical University reviewed decades of studies examining role of adaptive immunity in #Alzheimers. They show that adaptive immune cells, T & B cells, play crucial role. Learn More in Chinese Medical Journal ➡️ journals.lww.com/cmj/fulltext...

Study by #StellerLab @rockefelleruniv.bsky.social demos that boosting levels of the protein PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to #Parkinsons. PNAS www.pnas.org/doi/10.1073/...

In the American Journal of Medicine, researchers John Dunn, et al. @floridaatlantic.bsky.social urge implementation of coordinated efforts to support lifestyle-based interventions that can help reduce the growing burden of cognitive decline. Learn More 👉 www.amjmed.com/article/S000...

A large-scale dietary trial by Dafna Pachter, Anat Yaskolka Meir, et al. @bengurionuni.bsky.social has shown that a green- #MediterraneanDiet can slow brain aging by altering key blood proteins linked to #Neurodegeneration. In Clinical Nutrition 🧠 www.clinicalnutritionjournal.com/article/S026...

TWO WEEKS AWAY 🧠 On Wednesday, October 1st, 2025, I look forward to presenting at annual American Legion Family Brain Sciences Lecture: "A Glimpse into #AlzheimersDisease: Unraveling Synaptic Plasticity and Hematopoietic Influence via the Gut". It is truly an honor.

New Research by Thomas Willnow, et al. reveals that a gene mutation tied to #Alzheimers disrupts production of exosomes, cellular particles essential for communication between brain cells. Learn More @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Today, Sept 11, 2025, we sadly mark the 24th anniversary of the 9/11 terrorist attacks on the #WorldTradeCenter in New York City, the Pentagon, and United Airlines Flight 93 which crashed in suburban Pennsylvania. No words can express the sorrow of this day. Take a moment, remember and #NeverForget.

Research by Xiaodi Zhang, et al. "suggests that fine-particulate #AirPollution can drive devastating forms of #Dementia by triggering the formation of toxic clumps of protein that destroy nerve cells as they spread through the brain." @science.org www.science.org/doi/10.1126/...

Research by Boram Kim, Kaitlin Blam, Holly Elser, et al. @pennmedicine.bsky.social shows link between more severe #Dementia & #AlzheimersDisease & high exposure to #AirPollution. @jamaneurology.com 👉 jamanetwork.com/journals/jam... Overview 👉 www.insideprecisionmedicine.com/topics/trans...

Yesterday, I was deeply saddened to learn of the passing of Dr. David Baltimore. A hero of mine, Dr. Baltimore's passing is a great loss to the scientific community; we will miss him. Learn More about Dr. Baltimore's 'Sixty Years of Discovery'! 👉 www.annualreviews.org/content/jour...

🎉 Congratulations to Dr. Eun-Jeong Yang for receiving the 2025 Joseph & Nancy DiSabato Research Scholar Award for "Pre-clinical evaluation of safety & efficacy of #Alzheimers immuno-therapeutics delivered w/ focused ultrasound".💯 Here, Dr. Yang discusses her work 👉 www.youtube.com/watch?v=C__E...

"A simple brainwave test developed by George Stothart, et al. @uniofbath.bsky.social has been shown to detect signs of memory impairment linked to #AlzheimersDisease years before clinical diagnosis is typically possible." Learn More in Brain Communications academic.oup.com/braincomms/a...

New large-scale study shows that #Alzheimers is marked by erosion of epigenomic control & suggests that Alzheimer's is not just about plaques & tangles, but about fundamental breakdowns in genome regulation that may open new doors for treatment. @cellpress.bsky.social www.cell.com/cell/fulltex...

Ever since @fda.gov granted traditional approval to lecanemab and its competitor donanemab, clinicians have been collecting and reporting information about their real-world experience with the 2 antiamyloid monoclonal antibodies. Learn More @jama.com Medical News jamanetwork.com/journals/jam...

Researchers Priya Makhijani, Olga Rojas, Julie Andersen, Daniel Winer, et al. have "uncovered a surprising link between gut immune cells and the brain in #AlzheimersDisease." Learn More @cellpress.bsky.social www.cell.com/cell-reports... @buckinstitute.org

In new study, researchers Eleanna Varangis, Seonjoo Lee, et al. @uofmichigan.bsky.social & @columbiauniversity.bsky.social found that neural flexibility was significantly higher in a group of people w/ #Alzheimers than in cognitively normal group. Learn More journals.sagepub.com/doi/10.1177/...

MARK YOUR CALENDARS 📅 On 10/8, Council for Responsible Nutrition's 2025 'Science in Session' conference will Dive Into Power of Bioactives for Human Health. I will present "Plant polyphenol metabolites and resilience to stress-induced mood and anxiety". Very exciting! Learn More www.crnusa.org

Led by Dr Hilmar Bading @uniheidelberg.bsky.social, researchers have discovered that a toxic complex formed between NMDA receptors & TRPM4 channels drives neuron death in #AlzheimersDisease. Learn More in Molecular Psychiatry @natureportfolio.nature.com www.nature.com/articles/s41...

In observational study of healthcare professionals, Yuxi Liu, Xiao Gu, Yanping Li, Dong D. Wang, et al. found that people who carried #Alzheimers APOE4 risk gene had lower risk of developing #Dementia if they followed #MediterraneanDiet. @naturemedicine.bsky.social www.nature.com/articles/s41...

In new study, Masihuz Zaman, Shu Yang, Ya Huang, et al. @stjuderesearch.bsky.social "reveal that protein midkine plays preventative role against #Alzheimers by blocking amyloid beta from forming harmful clumps." Learn More in Nature Structural & Molecular Biology 👉 www.nature.com/articles/s41...

🍁 FALL IS COMING 🍁 On Wednesday, October 1st, 2025, I look forward to presenting at annual American Legion Family Brain Sciences Lecture: "A Glimpse into #AlzheimersDisease: Unraveling Synaptic Plasticity and Hematopoietic Influence via the Gut". It is truly an honor.

In new study, researchers Laura Remesal, et al. ID ferritin light chain 1, an iron-associated protein, as pro-aging neuronal factor that impairs cognition. The discovery suggests that one protein could be master switch for aging in brain. Learn More in Nature Aging 👉 www.nature.com/articles/s43...

Many health life exposure factors influence cognitive decline & dementia incidence, but their relative importance to episodic memory among diverse older adults is unclear. Learn More in #Alzheimers & #Dementia Journal @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A fading sense of smell can be one of the earliest signs of #Alzheimers even before cognitive impairments manifest. Research @dzne.science & @lmumuenchen.bsky.social sheds new light on this phenomenon, pointing to a significant role for the brain’s immune response. www.nature.com/articles/s41...

A new study by Puja Agarwal, Sonal Agrawal, Julie Schneider, et al. @rushalzheimers.bsky.social provides more evidence that #MIND & other diets like it can protect against #Dementia – as well as giving us some clues as to why. Learn More @jamanetworkopen.com 👉 jamanetwork.com/journals/jam...

🚀 COMING UP FAST 🚀 On Wednesday, October 1st, 2025, I look forward to presenting at annual American Legion Family Brain Sciences Lecture: "A Glimpse into #AlzheimersDisease: Unraveling Synaptic Plasticity and Hematopoietic Influence via the Gut". It is truly an honor.

A new study from researchers Quinn Lee, et al. at UIC College of Medicine "reveals how the #BloodBrainBarrier gets leakier w/ age, contributing to memory deficits. The study uncovered the molecular mechanisms behind this process." Learn More @cp-cellreports.bsky.social 👉 www.cell.com/cell-reports...

In this study, Jay Lusk, Cassie Ford, Samir Soneji, et al. found that male patients w/ #Dementia had higher mortality rates & higher use of many health care services, especially hospital stays, than comparable female patients. ‪Learn More @jama.com 👉 jamanetwork.com/journals/jam...

Researchers Xu Chen, Bokai Zhu, et al. found that reshaping nuclear speckles, tiny structures inside cell nuclei that regulate protein maintenance, could be a novel way to treat proteinopathies like #Alzheimers #Parkinsons & prion diseases. @natureportfolio.nature.com👉 www.nature.com/articles/s41...

I am thrilled to highlight groundbreaking findings from US POINTER study. The POINTER study, primarily funded & directed by @alzassociation.bsky.social, demos that a multidomain lifestyle intervention could improve cognitive function in at-risk individuals @jama.com👉 jamanetwork.com/journals/jam...

Interesting! Ricardo Santana, et al. @ucirvine.bsky.social report that combination of naturally occurring compounds, nicotinamide & epigallocatechin gallate, can reinstate levels of guanosine triphosphate, an essential energy molecule in brain cells. GeroScience ➡️ link.springer.com/article/10.1...

The earliest molecular changes in #Alzheimers are poorly understood. Here, Liviu Aron, Zhen Kai Ngian, Chenxi Qiu, Bruce Yankner, et al. show that endogenous lithium is dynamically regulated in brain & contributes to cognitive preservation during #Ageing" @nature.com 👉 www.nature.com/articles/s41...

Here, Roman Kosoy, John Fullard, et al. @mountsinainyc.bsky.social present transcriptional analysis of primary microglia from 189 human postmortem brains. These data further our understanding of key role #Microglia have in AD biology. Learn More in Nature Neuroscience www.nature.com/articles/s41...

Using a custom-built tool to analyze electrical activity from neurons, researchers Danylyna Shpakivska-Bilan, et al. @ucm.es have identified a brain-based biomarker that could be used to predict whether mild cognitive impairment will develop into #Alzheimers. 👉 direct.mit.edu/imag/article...

Recent literature has explored contributions of oligodendrocytes & myelin dysfunction to #Alzheimers. Here, Anna Bright, Leyla Anne Akay, @joelwblanchard.bsky.social & Li-Huei Tsai discuss evidence oligodendrocytes may directly contribute to AD pathology & progression. www.nature.com/articles/s41...

Unable to JOIN the #PasinettiLab at the Alzheimer's Association International Conference (#AAIC25). CHECK OUT some of the work we presented ➡️ Role of acute exposure to environmental stressors in the gut-brain-periphery axis in presence of cognitive resilience 👉 www.sciencedirect.com/science/arti...

#Alzheimers is marked by toxic amyloid-beta protein clumps, but some people seem naturally protected. New Study by Beika Zhu, et al. at UCSF reveals molecular receptor called ADGRG1 enables #Microglia to effectively clear these harmful plaques. @cellpress.bsky.social 👉 www.cell.com/neuron/abstr...

EXCELLENT PAPER! Here, Yingjie Ding, et al. present a comprehensive proteomic & histological analysis of 516 samples from 13 human tissues spanning 5 decades & lay groundwork for systems-level understanding of human aging thru lens of proteins. @cellpress.bsky.social www.cell.com/cell/abstrac...

TODAY | 7/28, the #PasinettiLab is proud to be taking part @alzassociation.bsky.social International Conference! CHECK OUT👉"Role of gut microbiota-derived metabolites in #NeurodegenerativeDisorders involving protein misfolding & C9orf72 expansion assoc w/ #Dementia". Poster # 107287 👉 aaic.alz.org

TODAY, July 27th, the #PasinettiLab is proud to be taking part in the @alzassociation.bsky.social International Conference #AAIC25! JOIN US for VIRTUAL presentations of our work 👉 Poster 107252 and Poster 107389. @mountsinainyc.bsky.social JOIN US at #AAIC! LEARN MORE 👉 aaic.alz.org

TODAY and TOMORROW, the #PasinettiLab is proud to be taking part the @alzassociation.bsky.social International Conference #AAIC25! JOIN our IN-PERSON poster sessions: on July 27th, Poster 107233 and on July 28th, Poster 107287. @mountsinainyc.bsky.social LEARN MORE 👉 aaic.alz.org

In NEW STUDY, Sean Miller, Rahul Dhodapkar, Hande Eda Sutova, et al. sought to illuminate apparent similarities between #COVID brain fog & #Alzheimers, investigating whether #SARSCoV2 can lead to #Alzheimers - like plaques that might explain post-infection brain fog. www.science.org/doi/10.1126/...

Study by Caitlin Finney, et al. reframes APOE ε4 as pleiotropic immune modulator rather than AD-specific risk gene, providing foundation for precision biomarker dvlpmnt & early intervention strategies across #NeurodegenerativeDiseases. Learn More in Nature Medicine www.nature.com/articles/s41...