New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development. These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention. www.embl.org/news/science...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

🧪 A variant in the Jumonji cofactor Jarid2 – and thus in H3K27 methylation – is associated to compromised fertility in both humans and mice. Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2

Did you know organ systems and organ apparatuses aren’t the same? An apparatus is a group of organs with similar functions but different origins (analogous). A system is a group of organs that share both function and embryonic origin (homologous). #AnatomyFacts #EmbryologyInAction #DidYouKnowScience

This year I’ll try to also include some posts about how fascinating anatomy and embryology are — in both veterinary and human fields, since they share so many processes! Let's try...

Here comes September and a brand-new 2025/2026 academic year — Let's get started!

Interesting!! (Apart from the eye-catching animation :) )

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies. journals.biologists.com/dev/article/...

Changing profile to: Associate professor at @www.unizar.es ... ... I got tenured! ... Looking forward to start new long-lasting scientific projects and collaborations! :)

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9

How do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...

Today's plan: taking my little boys to see how awesome women and girls are in science! Happy International Day of Women and Girls in Science!👩‍🔬🧬👧🧑‍🦰🧬🔬

CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1

SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells go.nature.com/49NeNFN rdcu.be/d8LYD

📢‼️ Exciting new preprint from the lab by @nikhil-mishra.bsky.social et al, now out on @biorxivpreprint.bsky.social, reveals that the early embryo geometry spatiotemporally patterns zygotic genome activation (ZGA) in zebrafish. 🐟 tinyurl.com/Biorxiv-nmis... Read on to learn more... 👇

Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine. @socdevbio.bsky.social

📢 CUT&Tag version 3 Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript: www.biorxiv.org/content/10.1...

Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬 What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬 www.science.org/doi/full/10....

I am thrilled to share our latest work, released today 🤩 www-nature-com.insb.bib.cnrs.fr/articles/s41... It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.

Top in my to read list!

Injecting old mice with an RNA molecule seems to reverse some signs of ageing — helping them to live longer, regrow hair and maintain their physical and mental abilities https://go.nature.com/40F1BRv

A big mystery to me is what DNMT3B is doing in the male germline. It's expressed, but there is no strong KO phenotype like the other DNMTs. Antoine Peters and team @fmiscience.bsky.social do careful genetic dissection here, and show that DNMT3B indeed has a role www.nature.com/articles/s41...

A new lab, led by an amazing scientist and colleague, is about to open! Stay tuned for exciting new job opportunities!

Very happy to see this out! It was great to think deeply about integrating epigenetic variation into the genotype-phenotype map, from historical perspectives, to current research, to future possibilities. I hope others interested in these topics find the framework and scope of this review helpful.

New online! Epigenetic ageing clocks: statistical methods and emerging computational challenges

To kick off a great paper on the methylation patterns of the placenta – an organ as complex as it is fascinating! Congrats to @cwhanna.bsky.social and authors!

Hello! this is my first post in Bluesky :) Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!). Let's get started!