This is the equivalent of Jesus on a toast for developmental biologists 🧪

i actually like this solution for Edric. spice-filled space coffin and canonically it makes total sense that the Guild would try to hide how their navigators actually look like. kudos.

This is the mouse brain on psilocybin. One dose rewires the brain, and it's not random. Researchers mapped exactly which neural circuits change with the help of #OpenScience & #OpenSource tools. 🧠📈 Dive into why it matters for mental health treatment: https://bit.ly/4cEsaN4

OMG DUNE 3 TRAILER IS OUT!! SQUEEEEEEE!! youtu.be/3_9vCamtuPY?...

Boris Cherny created Claude Code. Then he open-sourced his entire setup for using it. Memory files, subagents, skills, the whole thing. Here's what's inside and why you should steal it:

The rarest of the rare! This holy-grail dream fish is a larval-stage #monkfish, aka #goosefish. Shot in the wild, using scuba, while diving at night over water several thousand feet deep, several miles offshore from Kumejima, Okinawa. #larvalfish #blackwater #gug #deepseafish

Inhibitory neurons are among the most transcriptomically diverse class of neurons in the CNS, with some brain regions having 60+ distinct cell types. Do humans share the same repertoire as rodents? Birds? Fish? 1/13

Remembering Barbara McClintock on International Women's Day! She discovered that genes aren't static, they can actually "jump" around on a chromosome. Her discovery of transposons ("jumping genes") fundamentally changed how we understand evolution and the complexity of DNA! 🧬🌽 #WomenInScience

Awwwwww

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Claude Code has a memory problem. Every new session starts from scratch. claude-mem fixes that. And it just crossed 33,000 stars on GitHub.

After years of work, the centerpiece of my PhD is published in @natmethods.nature.com! Read it to learn about the biophysical insights we can get from single-cell data! But first, I would like to talk a bit about RNA velocity and normalization. 1/

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

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Look, I don't know if this is true... I just want it to be

These dogs are having the time of their lives following this week's historic blizzard in the Northeast. Please enjoy. 14/10 for all

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Good news. The FDA will review Moderna’s mRNA flu shot, mRNA-1010, after initially refusing the application. If approved, the vaccine could be available for the 2026-27 flu season.

ལོ་གསར་བཀྲ་ཤིས་བདེ་ལེགས། Happy new fire horse year!

When your #zebrafish know more Gen Z slang than you do 🤣 h/t @drjulieb.bsky.social Source: zfin.org/ZDB-GENE-990...

CWRU is on the list. Maga fears us.

In terms of what cures are being lost: - Epstein-Barr virus is perhaps the major trigger for multiple sclerosis - herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis - shingles virus causes an intensely painful disease

That's cool.

🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down.

It is absolutely outrageous that Moderna’s flu vaccine was met with a “refusal-to-file” even after their approved their protocol with FDA and carried out the trial as agreed. This vaccine works better in older adults than the current flu vaccines. apnews.com/article/mode...

A woman discovered her dog had almost no brain after taking her to the vet for a seizure. This is Maggie. She had hydrocephalus, a fluid buildup in the brain cavity that filled 95% of her skull. Low sodium levels kept the disease at bay and allowed her to live to the ripe old age of 12. 13/10

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

I love this portrait of a scientist so much. Portrait of Dr Bouchard, by Tamara de Lempicka, 1928

“What is will power?” asked Toad. “Will power is trying hard NOT to do something that you really want to do,” said Frog.

Batch Effects Are Hiding in Your Variant Calls I thought my QC was solid. Then I found thousands of "variants" that weren't real. The signal? Variants on different chromosomes showing linkage disequilibrium. That's impossible in real biology.

RFK Jr. appointee Kirk Milhoan has just clearly stated, out loud, that he wants to experiment on the people of the United States by seeing what happens as vaccination coverage plummets and infectious diseases spread.

His name is Liam Ramos, and he is 5. He was abducted from Minneapolis and trafficked to a detention camp in Texas.

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

Imagine you're a scientist trying to publish a new study, and being told you can't, unless you do background checks on co-authors who aren't U.S. citizens and send their names to national security staff. Also, studies about climate change or DEI written w/foreign scientists = rejected. ⬇️

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"We need to ask ourselves, on both sides of the Atlantic, if we want to live in a world where democracy is recast as weakness, truth as opinion and justice as an option." Perfectly summed up by the secretary general of the Council of Europe. (gift article) www.nytimes.com/2026/01/19/o...

Catastrophe: Florida's Department of Health is stopping coverage for antivirals to 10,000 low-income people with HIV infection, blaming impending federal cuts to the AIDS Drug Assistance Program. 12.5% of Americans with HIV live in Florida.

🤔🤣 youtu.be/E1wYVdL8FsQ?...

🐰🙂

Donald Trump's billion-dollar-buy-in "Board of Peace" is just the Council of Ricks minus the hairdos 🔗: www.nytimes.com/2026/01/18/w...

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All of this going down during the 250th anniversary year of America is a degree of cringey writing that would be roundly mocked were it a novel published in an alternative timeline.

Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8

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Current mood

Our paper on the Expanded Registry of candidate cis-Regulatory Elements (cCREs) is out 🎉 www.nature.com/articles/s41... To celebrate, here’s a "meme-torial" walkthrough of the science. Let’s get started 🧵 1/11