NEW: A serious staffing shortage — of the Trump admin's own making — is delaying the agency's ability to send billions to universities around the country, leaving labs reeling in the meantime. “I thought we were at rock bottom”, a senior NIH official said. “We are below rock bottom now.”

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

This website shows you what your browser is leaking about you. sinceyouarrived.world/taken

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

NASA just dropped more than 12,000 photos from the Artemis II mission. It'll take me a few days to go through them all, but so far it's one stunner after another. Link: eol.jsc.nasa.gov/SearchPhotos... Credit: NASA/Artemis II Crew (h/t @jonostrower.com)

Guess the reports were true, Craig Venter has passed away. RIP. www.nytimes.com/2026/04/30/s...

AAAAAAAAAAAAAAAAAAAAAAAHHHH

Oh gods no 🤮

It is time...

AAAAAAAAAAAAAAHHHHHHHHHHHH

😮

Yaaaaaaassssssss! djmag.com/news/boards-...

It’s always “this meeting could’ve been an email” and never “this email could’ve been a fine cask of delectable amontillado wine”

We're proud to be a launch partner for OpenAI's GPT-Rosalind, a new model designed to support life sciences research. This collaboration is part of our broader effort to explore how AI can accelerate scientific discovery. 🔗 https://openai.com/index/introducing-gpt-rosalind/

Wow, J.D. really vanced the hell out of the Hungarian presidential election

Female octopuses throw rocks at males that bother them, documented in Octopus tetricus

Nine years. Good grief 😧

I don't remember seeing an image of Earth before that captures the (thin, fragile, tiny layer of) atmosphere so clearly. I mean, look at that.

✅ #Artemis II update: 'Earthset', 6 April 2026, and 'totality', 7 April, seen from lunar orbit, the Moon eclipses the Sun, a view few humans have ever witnessed (pics: NASA) 🔗 www.nasa.gov/gallery/jour... @exploration.esa.int l

This is Jomvet. She is the rootinest tootinest cowboy around with a two-ounce hat on her head and a yeehaw in her heart. 12/10 (IG: mha.mahamek)

AAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHH

🚨 Christina Koch has officially become the farthest any woman has ever traveled from Earth

😞

MUPPET TRENT REZNOR: what have I become / my swedish friend? SWEDISH CHEF: ervie wurr ye durr gurrs awerre en de ern

Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks @edinburgh-uni.bsky.social Enjoy! www.nature.com/articles/s41...

Congratulations to newest doctor, superstar Kate Letai! Her pioneering work on glia in GI diseases opened entirely new fields — and as her mentors @tesarlab.bsky.social and @marissascavuzzo.bsky.social put it today, she is the type of scientist who makes this field a better place. We are so proud! 🎉

The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

Oligodendrocyte precursor cell in the spinal cord of a transgenic zebrafish larva. Credit to @jiaxingli.bsky.social. #ZebrafishZunday 🧪

If you use GitHub (especially if you pay for it!!) consider doing this *immediately* Settings -> Privacy -> Disallow GitHub to train their models on your code. GitHub opted *everyone* into training. No matter if you pay for the service (like I do). WTH github.com/settings/cop...

AAAAAAAAAAAAAAAAAAAAAHHHH

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

Power attracts pathological personalities. It is not that power corrupts but that it is magnetic to the corruptible.

This is the equivalent of Jesus on a toast for developmental biologists 🧪

i actually like this solution for Edric. spice-filled space coffin and canonically it makes total sense that the Guild would try to hide how their navigators actually look like. kudos.

This is the mouse brain on psilocybin. One dose rewires the brain, and it's not random. Researchers mapped exactly which neural circuits change with the help of #OpenScience & #OpenSource tools. 🧠📈 Dive into why it matters for mental health treatment: https://bit.ly/4cEsaN4

OMG DUNE 3 TRAILER IS OUT!! SQUEEEEEEE!! youtu.be/3_9vCamtuPY?...

Boris Cherny created Claude Code. Then he open-sourced his entire setup for using it. Memory files, subagents, skills, the whole thing. Here's what's inside and why you should steal it:

The rarest of the rare! This holy-grail dream fish is a larval-stage #monkfish, aka #goosefish. Shot in the wild, using scuba, while diving at night over water several thousand feet deep, several miles offshore from Kumejima, Okinawa. #larvalfish #blackwater #gug #deepseafish

Inhibitory neurons are among the most transcriptomically diverse class of neurons in the CNS, with some brain regions having 60+ distinct cell types. Do humans share the same repertoire as rodents? Birds? Fish? 1/13

Remembering Barbara McClintock on International Women's Day! She discovered that genes aren't static, they can actually "jump" around on a chromosome. Her discovery of transposons ("jumping genes") fundamentally changed how we understand evolution and the complexity of DNA! 🧬🌽 #WomenInScience

Awwwwww

Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.

Claude Code has a memory problem. Every new session starts from scratch. claude-mem fixes that. And it just crossed 33,000 stars on GitHub.

After years of work, the centerpiece of my PhD is published in @natmethods.nature.com! Read it to learn about the biophysical insights we can get from single-cell data! But first, I would like to talk a bit about RNA velocity and normalization. 1/

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

AAAAAAAAAAHHHHHHHHHHHHHHH

Look, I don't know if this is true... I just want it to be

These dogs are having the time of their lives following this week's historic blizzard in the Northeast. Please enjoy. 14/10 for all

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.