Yes, they used a GNA resin for affinity capture- to demonstrate that small (s)EVs did not carry the mannose+ signature (the positive correlation improved after sEV depletion), thus large EVs were considered the ‘pathogenic’ ones. High variability limits the interpretation in this study.

Very thorough and thought-provoking review on #extracellularvesicles - clinical applications in cancer diagnostics, vaccines, and drug delivery systems, by Greening et al. Published in Nature Reviews Clinical Oncology: www.nature.com/articles/s41...

Obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate the buildup of amyloid-β plaques in the brain. www.sciencedaily.com/releases/202...

Bioengineering assistant professor Marley Dewey has received a National Institutes of Health (NIH) research award to support her work on recently discovered extracellular vesicles that play an important role in tissue repair.👏 Click here to read more: engineering.ucsb.edu/news/marley-...

The new issue of #ScienceSignaling is out! A study of fruit flies shows a common gut bacterium can enhance the rewarding properties of amphetamines, researchers uncover how proteins in extracellular vesicles can offer clues to HIV blockade, and more. https://scim.ag/45Up9V6

EV-microRNAs may serve as early predictors of subfertility in dairy cows. Congrats Pevindu for this final publication from his PhD and our time with Prof Murray Mitchell at QUT in Brisbane, Australia. 🇦🇺 #extracellularvesicles #biomarkers isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Dr. Dolores Di Vizio received the International Society for Extracellular Vesicles (ISEV) Special Achievement Award for her work showing large extracellular vesicles are functional mediators of #cancer progression. @isev.org bioquicknews.com/isev-2025-sp...

Very excited to share my postdoc work- out now at PNAS! Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

This rate of validation suggests that affinity reagents such as antibodies should be considered non-specific until proven otherwise: 357 validated antibodies out of 1,124 tested. .

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports. erictopol.substack.com/p/new-anti-a...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT www.verwaltung.uni-halle.de/dezern3/Auss... #Academicsky #Chemsky #teammassspec

Excited to share part two of our plant extracellular vesicles story on BioRxiv! Using proximity labeling the awesome power of genetics to figure out how these lil’ guys are secreted. Part one: doi.org/10.1002/jev2... Part two: www.biorxiv.org/content/10.1...

People are having very strange conversations with ChatGPT, in which they discover secret cabals or conspiracies or that we are all in fact living in The Matrix. It sends these people into delusional spirals. Then ChatGPT tells them to email me about it. www.nytimes.com/2025/06/13/t...

💡 This week I attended #ASMS2025 in Baltimore to present 'Deep proteome characterization unveils distinct secretory phenotypes of Wild Type and familial Alzheimer's Disease organoids'. Our findings shed light on how secretory differences may influence disease progression and biomarker discovery.

More insights into #glycoRNA, this time found within exosomes! www.nature.com/articles/s41...

Heading to #ASMS2025 next week? Check out our talks and posters from the Yates lab! See the poster below for details 😁👇 #proteomics #extracellularvesicles #massspec #glycoproteomics @jyates.bsky.social

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Ahhh my trusty qEV column, how I have missed you ❤️❤️❤️ Although, it’s still like watching paint dry 🤦🏻‍♀️😴 #extracellularvesicles #exosomes

Good news! My article received enough views to be a Top Viewed Article. Read it here: onlinelibrary.wiley.com/doi/10.1002/... #TopViewedArticle @wiley.com #milk #extracellularvesicles #proteomics #bioinformatics

Wow! Mitochondria can actually be transferred to other cells if needed through nanotubes, in extracellular bubble-shaped vesicles, or by free floating through the blood. buff.ly/33kcDdS Donating mitochondria to another cell may help to repair damaged cells or support immune function. #medsky 🧪

Cool new study showing glycoRNAs on circulating extracellular vesicles may have diagnostic utility #glycotime

pubs.acs.org/doi/10.1021/... Comparison of Protein Solubilization and Normalization Methods for #Proteomics Analysis of Extracellular Vesicles from Urine #extracellularvesicles

Linking this here for all #bioinformatics #proteomics #lipidomics #genomics #transcriptomics people… We are really experiencing a data reproducibility crisis, strongly linked to poor reporting practices. It’s time for a change- but needs your support! 🙏 www.linkedin.com/posts/natali...

‘The Diminishing of American Science’ The consequences of the NIH crisis is likely going to be far more extreme than we can even predict. Prof Yates sums it up nicely for the Analytical Scientist. #TeamMassSpec #proteomics #extracellularvesicles theanalyticalscientist.com/business-edu...

Quantitative Lipid Analysis of Extracellular Vesicle Preparations: A Perspective #JEV #MassSpec isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

‘Uptake of small #extracellularvesicles by recipient cells is facilitated by paracrine adhesion signalling’ 🧐 Of note is that this study was performed using 2 tumour cell lines and all sEVs isolated were CD63 positive, regardless of cell type and EV subtype. www.nature.com/articles/s41...

Post-Doc Position in the field of #extracellularvesicles availabe in Vienna/Austria, with #DirkStrunk, our Vice-President at ASEV 😎

Happy to say I’ll be attending #ASMS2025 in Baltimore this June! Even more exciting is that our submitted abstract was accepted as an oral- Looking forward to sharing some exciting data generated with a collaborator on #ExtracellularVesicles ;)

Missing #ISEV2025 this year? Never fear! The #rEViewPodcast has plenty of #ExtracellularVesicles content to keep your fomo at bay - and we hit a major milestone! 250 plays on Spotify and counting… 🥳🙌 open.spotify.com/show/5Mio0bU... youtube.com/@the_review_...

#TeamMassSpec #Proteomics It is simple to convert the DIA-NN parquet file to the tsv text format if your downstream tool requires tsv. Note that if you want to perform quantification at fragment level, remember to turn on the --export-quant switch. digitalbiologylab.github.io/posts/220301...

Check out our review on Recent Advances in Mass Spectrometry-based Bottom-Up #Proteomics, led by Jesse Meyer. It was a pleasure to contribute the section on Extracellular Vesicle proteomics 🙌 . pubs.acs.org/doi/10.1021/... #exosomes #extracellularvesicles

Saw the pre-print and was waiting for the publication for this one: “Histones as #exosome membrane proteins regulated by cell stress.” Exosomes contain mostly unmodified histones, distinct to their cellular counterparts. Full paper in #JEV: isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Two big reveals in the world of #extracellularvesicles this week: Blebbisomes www.nature.com/articles/s41... and the ‘torn bag mechanism’ of small EV release from amphiectosomes elifesciences.org/articles/958...

We're here!! Aaaand we need some help :) Calling all #proteomics researchers www.reddit.com/r/proteomics...

New - The Proteomics Show podcast drop! We've got the award winners, starting with the Costello Award winner for Exemplary Achievement in Proteomics - Dr. Ileana Cristae! @us-hupo.bsky.social

The next #rEViewpodcast is live! This episode we talk to Farouq Sharifpour @jcu about his research on all things Helminths 🪱 and Spirulina, including his latest 2 publications in JEV and JEx Bio. youtu.be/XjvH1c2payQ?... open.spotify.com/episode/3rWQ... #extracellularvesicles #exosomes @isev.org

One wild thing I learned recently is that AMPA receptors are regularly found in extracellular vesicles released by neurons, and that this release is stimulated by excitatory input. www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

Welcome to BlueSky @isev.org @anzsev.bsky.social @snevresearch.bsky.social ! All can be found in my #extracellularvesicles starter pack, now growing by the day 🙌

New to BlueSky? Here's a Starter Pack with EV researchers! Thanks @natalieturnerau.bsky.social for initiating this! go.bsky.app/7xmvSQ

Not all tRNA fragments (tDRs) are created equal. Here we share methods to differentiate: 1) real tDRs and those produced by dissociation of nicked tRNAs, 2) nicked tRNAs / tDRs in extracellular vesicles vs outside. 1) www.sciencedirect.com/science/arti... 2) www.sciencedirect.com/science/arti...

For those of you, who will attend #ISEV2025 in beautiful Vienna: We, as the local society #ASEV, will give an overview of our #extracellularvesicles landscape in Austria. You are welcome with a heartful "Servus" to join our satellite symposium, taking place on Friday, 25 April, from 5.45-7.15 pm 😊

Also on Spotify: open.spotify.com/episode/5EjX... #extracellularvesicles #exosomes #science #research #STEM #podcast #scicomm

Excited to announce the beginning of Season 2 of the rEView podcast! 🙌 Caterina Piunti talks to Alice Gualerzi, a Senior Researcher at LABION. Her research focuses on characterization of #extracellularvesicles for use in diagnostics and regenerative medicine. youtu.be/QqJv_PnOz60?...

Ohio State researchers uncover ion channels in extracellular vesicles, enhancing their potential in drug therapies by stabilizing cargo delivery.

Check out the brand new @gsevorg.bsky.social January 2025 Newsletter! Explore EV research updates, upcoming events in 2025 (IGLD/GSEV Spring Meeting, GSEV Autumn Meeting, new calls for MOVE scholarships), and more. Join us in advancing #extracellularvesicle research. ➡️http://gsev.org

Unsaturated Fatty Acids Are Decreased in Aβ Plaques in Alzheimer's Disease #JNeurochem #MassSpec onlinelibrary.wiley.com/doi/10.1111/...

Making space for spatial biology in the clinic Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz

Today our budding proteomics team had an online master class with proteome experts of the Bouhaddou lab at UCLA. bouhaddoulab.org/our-team-3 Prof. Mehdi will visit ASTAR and give a seminar here for anyone interested, Feb 17. Thank you Mehdi and Shipra! Check out their lab:

New study from the Olsen lab published in Nature [email protected] #TeamMassSpec #proteomics

Going down under to learn more about Proteins. Happy to participate in www.lorneproteins.org to talk about "what we think we know about (y)our antibodies"