I’m looking forward to this incredible opportunity to advance the science of antibiotic discovery with the Gr-ADI consortium.

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.

"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:

@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

🚨Deadline for our Senior Scientist applications is next week. If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...

📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections. If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below. www.linkedin.com/jobs/view/43...

Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.

We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad: idm.uct.ac.za/media/739223

Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!

Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

📢 PhD Opportunity @crick.ac.uk Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants. We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species. November deadlines. More details ⬇️🧵

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social More info below ⬇️

Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines

Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology. Chen Ed: jobs.calpoly.edu/en-us/job/55... Coatings: jobs.calpoly.edu/en-us/job/55...

The EMBL PhD programme is open until 13th October (entry ~Sep 2026): www.embl.org/about/info/e... We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them

Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...

My institution is looking to hire a new microbiologist: apply.interfolio.com/173702. Please share, and let me know if you have any questions about the position or UTA.

So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)

How to make training data from tacit knowledge in medicinal chemistry is one of the big challenges.

www.nature.com/articles/s41... #microsky

A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures. www.biorxiv.org/content/10.1...

Now available in a polished format! An important step toward accelerated functional genomics for the Cryptosporidium parasite. Brought to you by the incomparable @lucy-watson.bsky.social www.nature.com/articles/s41...

My Friday night hot take is that replication studies are largely a waste of time & $ If a result is worth following up on, it's better to address from a different angle & see if it holds water. Strong ideas withstand this Conversely, there R infinite ways a replication can fail that teach you zip

Are you excited about using cyclic #peptides in #DrugDiscovery? Here is a great opportunity to perform a #postdoc with a great mentor in the group of @ljwalport.bsky.social at @imperialcollegeldn.bsky.social! www.linkedin.com/posts/louise... #ChemBio #Chemistry #ChemSky

Interesting work on characterizing steroid-modifying enzymes in commensal gut bacteria: "Identification of gut bacteria reductases that biotransform steroid hormones" www.nature.com/articles/s41...

Working link here! www.biorxiv.org/content/10.1...

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

Cool to see this elegant approach finally pre-printed!

📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...

Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...

New post: The age of the undruggable is over. The age of the unassayable is here. medchemash.substack.com/p/the-age-of...

We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227

Kansas #tuberculosis outbreak is now America's largest in recorded history. There were 51 #TB cases in the state in 2023, 109 in 2024 and 1 so far this year, by Jason Alatidd www.cjonline.com/story/news/p... via @cjonline.bsky.social @infectiousdz.bsky.social

⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring #TBSky #IDSky @nejm.org www.nejm.org/doi/10.1056/...

Interested in Mtb pathogenesis and developing new strategies to treat these deadly infections? Please apply to join us for the GRC for Tuberculosis Drug Discovery and Development!! www.grc.org/tuberculosis... Deadline to submit an abstract to be considered for a talk is March 1st! Please repost!

Cool new preprint from @stanford-chemh.bsky.social fellow @mbogyo.bsky.social @stanfordmedicine.bsky.social www.researchsquare.com/article/rs-5...

Featured preprints include our #majetilab collaboration with the Feinberg lab using gene correction of primary samples to reveal that the pre-leukemic mutations in DNMT3A is dispensable for AML disease maintenance. Read here ➡️ www.biorxiv.org/content/10.1... @stanforddeptmed.bsky.social

Evolution of antibiotic resistance #AMR can lead to collateral resistance/sensitivity to other drugs; @jeffmaltas.bsky.social &co show that these effects can fluctuate over time, needing precise timing & stochastic control models to optimize treatment strategies 🧪 @plosbiology.org plos.io/3C2Ao1y