(S)-cargot (R)-cargot

Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb

Even I’m not sure this will end well. Graphics courtesy of Dylan Patel of SemiAnalysis.

📆 Deadline: 14 November. 🩺 Doctoral Clinical Fellows programme (3-year PhD) 🤝 Exciting collaboration with the amazing @jeanninehess.bsky.social Curating bioactive chemical space in pathogenic bacteria using accumulation signatures across species ✍️ Apply here: www.crick.ac.uk/careers-stud...

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

On the benefits of a 4-day work week: www.nature.com/articles/d41...

📣Preprint 📣 You want to degrade a protein in Gram-negatives? We have tackled this challenge! Detailed study of our Light-Activated Metal-Dependent Protein Degradation LAMP-D system in targeting and rescuing NDM-1 activity. What an amazing team effort 🫶🏻 doi.org/10.26434/che...

Imagine a small molecule that degrades a target protein like PROTACs, but does so independently of any of the host cell's degradation machinery, so you can go and do targeted protein degradation in gram-negative bacteria: doi.org/10.26434/che...

If you're looking to do a PhD in bioinorganic and medicinal chemistry in a wonderful research group at a world-leading institute, here's a great opportunity: www.crick.ac.uk/careers-stud... @jeanninehess.bsky.social

Happy New Year!

Great transition into the new year with a well-organised party...

A white Christmas for once...

Little copycats in the house...

Collum #chemsky

Do not confuse... chemsky

Do not confuse...

Do not confuse...

⚠Invalid Handel

Thanks @cambridgeindy.bsky.social for publishing my view on closing the Mill Road Bridge for private vehicles.

"Prioritizing family life has earned me respect in my field — and my research has improved, too" www.nature.com/articles/d41...

Quite faint in the middle of town, but one could clearly see the northern lights in Cambridge, UK.

You wouldn’t think that formaldehyde is an actual cellular signaling molecule, would you? But here we are!

This report on the CACHE competition is worth a read. It’s about as close as we’ve gotten to some open benchmarking of AI impact to the drug discovery process. I’d suggest a title change to “When Can AI Deliver the Drugs?” though. A few more thoughts👇 1/

Absolutely agree. And I only play the nice guy on here, but reality might be closer to this meme:

"Then they took the extra step, rarely realized in such papers [...], of actually synthesizing hundreds of the hit molecules and experimentally testing them against the real proteins. (Faint cheers can be heard echoing from the lab benches and fume hoods)." 😅

We should spend a massively less amount of time politically kneecapping our most globally competitive export industry that employs more than 2% of the entire US workforce

Towards a better society by limiting wealth accumulation? A great take on Ingrid Robeyns' Limitarianism: www.theguardian.com/books/2024/j...

Jensen Huang’s comments from JPM24 are now summarized in a Nvidia blog post. He doubles down on exactly the kinds of things that I’ve been cautioning are wildly optimistic. More below. 👇🏽 1/

"What I actually want is for sequencers to be as boring and simple as a qPCR machine." Nava Whiteford on the future of Sequencing aseq.substack.com/p/the-future...

Happy new year......

In the Venn diagram of results, my results never seem to overlap with sense

Happy New Year!

Merry Christmas!

When you only have scientific magazines at hand for some arts and crafts with your daughter...