Review @natrevrheum.nature.com @georgearobinson.bsky.social @ucl.ac.uk Insights into the pathogenesis of childhood-onset SLE in the past decade www.nature.com/articles/s41...

podcasts.apple.com/jp/podcast/t... One of my favorite podcast is highlighting #lupus in this episode🎧Yay🧡 @immunologypodcast.com

Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus @thelancet.com www.thelancet.com/journals/lan... www.thelancet.com/journals/lan...

www.science.org/doi/10.1126/... 📖”This marks a critical point in B cell fate commitment, whereby CD21 down-regulation initiates EF B cell proliferation and differentiation, driving the rapid production of ASCs. “ #Bcell #SLE #lupus

www.nature.com/articles/s41... 📖 “Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice” #SLE #lupus #Bcell

www.science.org/doi/10.1126/... “These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.” #SLE #Bcell #EBV

www.science.org/doi/10.1126/... “RA is characterized by pathological fibroblast-like synoviocytes (FLSs)... To address this, Huang et al. focused on the role of small nucleolar RNA, C/D box 3 (SNORD3), which is up-regulated by inflammatory modulators that are important in RA models.” #arthritis

Review: Pathogenic drivers of lupus myocarditis and potential therapeutic targets @taejoonw.bsky.social www.nature.com/articles/s12...

@natrevrheum.nature.com Cutaneous lupus erythematosus — from pathogenesis to targeted therapy @kahlenberglab.bsky.social www.nature.com/articles/s41...

www.science.org/doi/10.1126/... 📖”Through a lineage-tracing approach, they detected conversion of synovial TH17 cells to CD44+ IFN-γ−IL-10− exTH17 cells, which are arthritogenic and cause joint inflammation independent of IL-17. “ #Th17 #arthritis

www.cell.com/immunity/abs... 📖 Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development #Tfh #germinalcenter

TLR7 drives age-associated B cell formation in lupus through m6A demethylase FTO-mediated mitochondrial oxidation www.science.org/doi/10.1126/...

🆕 Clinical Year in Review at #ACR25 By Dr. Bryant England @unmc.bsky.social 🔶 Review the most impactful studies in #Rheumatology from the past year! ❓ Any studies you would add to the list? #RheumSky #MedSky #YearInReview

🆕 2025 ACR Guideline for Treatment of Systemic #Lupus Erythematosus 🦋 Just Released: Nov 3 #ACR25 🔥 🔸Review organ-specific treatment recommendations 🔸Steroid & HCQ Use Guidance 🔸Management of Comorbidities ➠ Read the Full Guideline here: acr.tw/47mkegj #RheumSky #SLE #Rheumatology

S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox www.jci.org/articles/vie... @jci.org www.jci.org/articles/vie...

Now published: The 2025 ACR Guideline for the Treatment of Systemic Lupus Erythematosus 📄 Read the paper: acr.tw/47mkegj ℹ️ See additional content and resources on this guideline at acr.tw/4mbHK4W #Medsky #Rheumsky #Rheumatology

www.thelancet.com/journals/lan... 👉”Fc receptor blockade by nipocalimab 15 mg/kg significantly improved clinical disease activity versus placebo and was safe and well tolerated in participants with moderate-to-severe, active Sjögren's disease.” #Sjogren #PhaseII

www.sciencedirect.com/science/arti... 📖 GZMK+CD8+ T cells target a specific acinar cell type in Sjögren's disease #Sjogren #Tcell

www.nature.com/articles/s41... 📖 “The exonuclease PLD4 helps restrain activation of TLR7 and TLR9 by cleaving their ligands. …identified loss-of-function variants in PLD4 in five patients with #SLE, linking disruption of this regulatory mechanism with systemic inflammation and #autoimmunity.”

www.nature.com/articles/s41... 📖”Telitacicept, a dual inhibitor of BAFF and APRIL, has now been shown in a phase III randomized controlled trial to improve systemic lupus erythematosus (SLE) disease activity when added to standard therapy.” #SLE #lupus #phaseIII

Andrew Yee: CAR-T vs bispecific antibodies? #ACR25

🆕 ACR 2025 Guidelines for Treatment of Systemic Lupus Erythematosus 🦋 #ACR25 #Lupus #RheumSky

IMPORTANT ANNOUCEMENT❗️ YOU CAN SNUGGLE PUPPIES IN THE RELAXATION AREA!!! Also, they will be adoptable very soon if you’re in the market for a new best friend! #ACR25 #chooserheum #Rheumatology

New recipe improves creation of cells that could fight most autoimmune diseases @science.org Nobel laureate makes regulatory T cells that last longer in the body, boosting clinical hopes www.science.org/content/arti...

www.nature.com/articles/s41... “Single-cell transcriptomic analysis of blood CD4+ T cells from children with systemic lupus erythematosus (SLE) reveals an unexpected diversity of helper and regulatory cells that could underlie disease flares and organ damage.” #SLE #lupus #Tcell

www.nature.com/articles/s41... 📖“A co-stimulatory signal via the coinhibitory TIGIT”

#ACR25 poster tours will be available in different languages!

www.nature.com/articles/s41... “we observed an expansion of dysfunctional #Treg in pts with #lupusnephritis, along with↑ of TLR5 and FCRL3 in naive Treg… These findings highlight distinct CD4⁺ T cell subsets that may contribute to aberrant antibody responses and impaired immune regulation in #SLE.”

www.nature.com/articles/s41... 📖Research Briefing Glomerular cross-talk in the progression of autoimmune kidney disease #ANCA #SLE #nephritis

BREAKING NEWS: The FDA has approved Gazyva® (obinutuzumab) for the treatment of adults with #lupus nephritis. Gazyva is the fourth therapy for lupus to receive regulatory approval since 2011. Read the announcement: buff.ly/81tYgo7

Efficacy of Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL, in adults with active systemic lupus erythematosus @nejm.org www.nejm.org/doi/full/10....

#ACR25 countdown Highlighting some work being presented at this meeting NEXT WEEK by colleagues who are on this platform (say hi & comment on their work!) #Rheumatology #MedSky 🧪

www.sciencedirect.com/science/arti... 📖🆕 EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update #lupus #SLE #lupusnephritis 🦋🫘

www.nature.com/articles/s41... 📖 Developing cell therapies for lupus #lupus #SLE

📣Upcoming webinar announcement 👇Register for 🆓 #APLAR #AYR #webinar #osteoporosis 🔗 us06web.zoom.us/webinar/regi...

Rheumatoid arthritis synovial fibroblasts modulate T cell activation @insight.jci.org @mskcancercenter.bsky.social insight.jci.org/articles/vie...

BATF3+ B cells are induced by specific receptor signals and express the ligand IL-27 and CXCL10 to play diverse regulatory roles www.science.org/doi/10.1126/...

The class of immune cells at the centre of Monday’s Nobel prize is showing promise as a treatment for autoimmune diseases, cancer and even organ transplants — but there are still key challenges to overcome before these cells can be used in therapies in the clinic. go.nature.com/4nGC5V9

www.nature.com/articles/d41... “Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ 🎊” “Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.” #autoimmune #Tcell #Treg #immunology

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Fragility fractures remain a common & serious complication of long-term oral glucocorticoid therapy that can affect all skeletal sites although the spine is particularly prone to fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky

www.nature.com/articles/s41... Original article📖→ www.nejm.org/doi/10.1056/... “In vivo CD19 CAR T-cell therapy for refractory systemic lupus erythematosus.” N. Engl. J. Med. #SLE #lupus #CART

Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis @jci.org www.jci.org/articles/vie...

Review @natrevimmunol.nature.com Regulators of CD8+ T cell exhaustion www.nature.com/articles/s41...

academic.oup.com/jimmunol/adv... “Dynamic control of autoreactive B cells from spontaneous germinal centers” 🐭 #SLE #lupus #autoantibody

www.nature.com/articles/s41... “Here we provide a high-resolution spatial kidney cell atlas of 57 samples from patients with RPGN ( #ANCA -associated GN, #lupus nephritis and anti-glomerular basement membrane-GN) to characterize the cell signaling pathways in glomerular crescent development.” 🫘🗺️

The loss of naïve-like precursor T follicular regulatory cells during COVID-19 correlates with autoantibody production www.science.org/doi/10.1126/...

www.science.org/doi/10.1126/... 📖”Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation” #RA #Tcell #Bcell #arthritis

📣Upcoming webinar announcement 👇Register for 🆓 😉❣️ #APLAR #AYR #webinar #WorldArthritisDay #gout

www.nature.com/articles/s41... #lupusnephritis #lupus #SLE