BREAKING NEWS: The FDA has approved Gazyva® (obinutuzumab) for the treatment of adults with #lupus nephritis. Gazyva is the fourth therapy for lupus to receive regulatory approval since 2011. Read the announcement: buff.ly/81tYgo7

Efficacy of Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL, in adults with active systemic lupus erythematosus @nejm.org www.nejm.org/doi/full/10....

#ACR25 countdown Highlighting some work being presented at this meeting NEXT WEEK by colleagues who are on this platform (say hi & comment on their work!) #Rheumatology #MedSky 🧪

www.sciencedirect.com/science/arti... 📖🆕 EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update #lupus #SLE #lupusnephritis 🦋🫘

www.nature.com/articles/s41... 📖 Developing cell therapies for lupus #lupus #SLE

📣Upcoming webinar announcement 👇Register for 🆓 #APLAR #AYR #webinar #osteoporosis 🔗 us06web.zoom.us/webinar/regi...

Rheumatoid arthritis synovial fibroblasts modulate T cell activation @insight.jci.org @mskcancercenter.bsky.social insight.jci.org/articles/vie...

BATF3+ B cells are induced by specific receptor signals and express the ligand IL-27 and CXCL10 to play diverse regulatory roles www.science.org/doi/10.1126/...

The class of immune cells at the centre of Monday’s Nobel prize is showing promise as a treatment for autoimmune diseases, cancer and even organ transplants — but there are still key challenges to overcome before these cells can be used in therapies in the clinic. go.nature.com/4nGC5V9

www.nature.com/articles/d41... “Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ 🎊” “Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.” #autoimmune #Tcell #Treg #immunology

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Fragility fractures remain a common & serious complication of long-term oral glucocorticoid therapy that can affect all skeletal sites although the spine is particularly prone to fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky

www.nature.com/articles/s41... Original article📖→ www.nejm.org/doi/10.1056/... “In vivo CD19 CAR T-cell therapy for refractory systemic lupus erythematosus.” N. Engl. J. Med. #SLE #lupus #CART

Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis @jci.org www.jci.org/articles/vie...

Review @natrevimmunol.nature.com Regulators of CD8+ T cell exhaustion www.nature.com/articles/s41...

academic.oup.com/jimmunol/adv... “Dynamic control of autoreactive B cells from spontaneous germinal centers” 🐭 #SLE #lupus #autoantibody

www.nature.com/articles/s41... “Here we provide a high-resolution spatial kidney cell atlas of 57 samples from patients with RPGN ( #ANCA -associated GN, #lupus nephritis and anti-glomerular basement membrane-GN) to characterize the cell signaling pathways in glomerular crescent development.” 🫘🗺️

The loss of naïve-like precursor T follicular regulatory cells during COVID-19 correlates with autoantibody production www.science.org/doi/10.1126/...

www.science.org/doi/10.1126/... 📖”Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation” #RA #Tcell #Bcell #arthritis

📣Upcoming webinar announcement 👇Register for 🆓 😉❣️ #APLAR #AYR #webinar #WorldArthritisDay #gout

www.nature.com/articles/s41... #lupusnephritis #lupus #SLE

Register today for the first FOCIS Journal Club! Free for all (non-members need a code at check-out)! 🔬 Dive into cutting-edge translational immunology 💬 Connect with experts & peers 🌍 Join the global FOCIS community Learn more & register: zurl.co/elAO1

www.nature.com/articles/s41... 📖”Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation” #Sjogren #SSA #centromere

www.cell.com/immunity/abs... 📖A roadmap for defining “extrafollicular” B cell responses #Bcell

pubmed.ncbi.nlm.nih.gov/40964009/ Preprint 📖”Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus” #lupus #Tph #Tfh

www.sciencedirect.com/science/arti... 📖 Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in #lupus nephritis “We identified VCAM1-expressing proximal tubule cells as components of an LN-specific inflammatory niche localised in the kidney cortex.“

pubmed.ncbi.nlm.nih.gov/40968927/ 📖 “Human Atypical B Cells. An Overview” #ABC #Bcell #Immunologicalreviews

😍 #doglover

www.nature.com/articles/s41... “Using CRISPR-interference screens, we confirm that emVar-containing T cell cis-regulatory elements modulate target genes that regulate T cell proliferation, providing plausible mechanisms by which these variants alter #autoimmune disease risk.” #Tcell #gene

Have your voice heard: National Lupus Survey now open! If you or someone you know lives with #lupus, please share 🙏 Take the survey now: surveymonkey.com/r/ACELCNatio... #ArthritisAwarenessMonth #ACESurvey @schroeder-uhn.bsky.social @lupuschat.bsky.social @arthritispower.bsky.social

www.nature.com/articles/s41... “CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential.” #Tfh #Tcell #Immunosky

‘Lipstick on a pig’: how to fight back against a peer-review bully @nature.com @katarinazimmer.bsky.social www.nature.com/articles/d41...

www.nature.com/articles/s41... “Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity” #Tfh #Tcell

www.sciencedirect.com/science/arti... 📖 “IL-2 signalling sustains pathogenic age-associated B cell homeostasis in lupus” #IL2 #Bcell #ABC #lupus #Rheumsky

📖”Loss-of-function mutations in PLD4 lead to systemic #lupus erythematosus” 👉 PLD4 loss-of-function mutations led to excessive activation of TLR7 and TLR9. Downstream…especially type I IFN signalling, were hyperactivated in patient dendritic cells. #monogenic #SLE #Rheumsky

The STING/type I interferon axis drives the interplay between marginal zone B cells and T follicular helper cells in Sjögren’s disease www.nature.com/articles/s41...

In patients with SLE, the adaptive immunity reconstituted faster after CAR T-cell therapy than in patients with B-NHL. buff.ly/6i0bDpC #hemesky

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity @natimmunol.nature.com @groomlab.bsky.social www.nature.com/articles/s41...

www.pnas.org/doi/10.1073/... 📖 Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis “….macrophage-expressed MS4A4A may represent a biomarker of joint inflammation in RA and a target to amplify the therapeutic activity of corticosteroids.” #arthritis

www.thelancet.com/journals/lan... COMMENT 📖“Targeting B-cell activation to tackle both patient-reported and systemic disease outcomes in Sjögren's disease” #Bcell #Sjogren

Perianal fistulizing Crohn’s disease occurs in up to 40% of patients with CD, but its etiology remains poorly understood. In this research letter, Siyan Cao & team use sing-cell and spatial muli-omics, revealing IFN-γ hyperactivated pathways: buff.ly/szCzSDk

rheumnow.com/news/aplar-2... 📖APLAR 2025: What’s New in RA Management? #RA #rheumatoidarthritis #aplar25 #APLAR @rheumnow.bsky.social

Review @natrevrheum.nature.com Emerging therapies for the treatment of systemic sclerosis www.nature.com/articles/s41...

www.nature.com/articles/s41... 📖 Metabolic control of innate-like T cells Review📚 #Tcell

www.nature.com/articles/s41... 📖”Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis” 👉B cell-produced LTαβ2 and LTα3 have distinct roles in ileitis, with the role of LTα3 unexpectedly protective through counterbalancing TNF.⚖️ Amazing 🤩!! #Bcell #TLS #TNF #Immunosky

Our recent paper was highlighted in @natrevrheum.nature.com😊 Original paper: www.science.org/doi/10.1126/... I forgot to mention this before, but I would like to thank @cnfogg.bsky.social & @hannah-isles.bsky.social for their smooth handling of our paper!

www.sciencedirect.com/science/arti... 🆕 “ERS/EULAR clinical practice guidelines for connective tissue diseases associated interstitial lung disease”📖 #guidelines #ILD #Rheumsky 🫁

www.nature.com/articles/s41... 📖”Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity” 👉 STING+LTβR activation results in CD8+T cell dependent tumor suppression while generating functional TLS. #TLS

✨That was such an amazing presentation — and the work seems to be coming out soon in Nature Immunology! It was really exciting to learn more about the complexities of #lupus pathogenesis. Hoping this will lead to better clinical management ☺️🦋 #lupus #CD4 #Tcell #Rheumsky #Immunosky #SLE

Day3 #aplar25 recap📷 Plenary3 “Human #SLE” Prof V.Pascual 👉Th10=CXCL13-IL10+IL21+CXCR3+PD1+(contains CD38high) and Tph=CXCL13+IL10-IL21+ are both expanded in SLE🩸 👉 Unique Transcriptional Features of Naïve SLE Treg: FCRL3↑TLR5↑ …TLR5 Ligation decreases⬇️ SLE Naive Treg Suppressive Function #lupus