Another life lost too young to colorectal cancer, RIP James Van Der Beek. The time for better prevention, screening, and treatment is now. #CureCRC

“I am shocked and appalled,” one NCI scientist said. “We are moving funds away from so much promising research in order to do a preclinical study based on nonscientific ideas. It’s absurd.”

The CRUSH CRC 5K is just over a month away! join our team here: www.supportdukehealth.org/site/TR/Colo...

🚨 #REVIEW #PROGRESS 🚨 Fucosylation—the attachment of the dietary sugar L‑fucose to glycoproteins & glycolipids—is frequently altered in cancer. Bitaraf et al. outline its role in tumour progression and therapeutic response. 📖 👇

Thanks to @medpagetoday.com for interviewing me about our recent @jco-asco.bsky.social commentary on how medications can influence immunotherapy! www.medpagetoday.com/hematologyon...

I appreciate the write up from @dukemedschool.bsky.social on our recent @jco-asco.bsky.social commentary regarding how common medications can interact with immunotherapy! corporate.dukehealth.org/news/over-co...

My mom ran the HIV prevention program for Hillsborough county (before it was shut down by Jeb Bush) which was one of my first volunteering experiences, inspiring me to pursue medicine. I witnessed so much pain, and many people are still suffering - the depth of this cruelty cannot be overstated.

New @naturemedicine.bsky.social The power of our mind to shape immune response, as seen in a randomized trial of trained neurofeedback for increased reward activity. More positive expectation-> more antibody response nature.com/articles/s41... nature.com/articles/s41...

Anti-PD-1 > Anti-PD-L1, due to the existence of PD-L2. It may explain why PD-L1 is such a meh biomarker in many tumors, too. ascopubs.org/doi/pdf/10.1...

Here is our publication in @jco-asco.bsky.social! We describe how common medications impact immunotherapy, how this affects practice and patients today, and outline ways to leverage this knowledge toward improved patient as well as our understanding of tumor immunology. ascopubs.org/doi/10.1200/...

For the first time, the five-year survival rate for all cancers has reached 70 percent, according to a new report, a trend that reflects the effectiveness of early prevention and detection strategies, and advancements in treatment and care, experts say. https://wapo.st/45T6Zm3

Here is our publication in @jco-asco.bsky.social! We describe how common medications impact immunotherapy, how this affects practice and patients today, and outline ways to leverage this knowledge toward improved patient as well as our understanding of tumor immunology. ascopubs.org/doi/10.1200/...

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

🗨️ “Vaccines have done more to improve public health than any other medical intervention.” A Viewpoint focuses on cancer vaccines and the future of immunotherapy: spkl.io/63322AYP7k

For every trainee who succeeds at getting some super difficult experiment to yield interesting results, there are another dozen who fruitlessly spun their wheels for years. My advice: explore many technically feasible experiments and follow up on interesting leads

High fat diets “ready the soil” for cancer to grow in the liver. This has been inferred to many degrees for years but its good to see some mechanism: www.cell.com/cell/fulltex...

Americans & Europeans needlessly exposing African babies to preventable diseases just to see if they can find something that would justify their preexisting antivaccine beliefs is not only unscientific and actually anti-science, it is very much reminiscent of colonialist, racist human rights abuses

At the colorectal cancer alliance summit, where the goal is very, very clear:

Important PSA:

Prasad, Makary and others who claim that COVID19 vaccines killed 10 children are not telling the truth. According to @jeremyfaust.bsky.social, the committee that worked on this question reported that there were ZERO deaths that they were certain were caused by the vaccines. Well worth reading.

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

The biggest clue to cranks that there is no vaccine conspiracy is that Doctors and Scientists continue to vaccinate their own children at record rates.

Save the date: Saturday, March 14th, 2026 join us for the CRUSH Colorectal Cancer 5K at The River Church in Durham. Support our patients, advocates/caregivers, researchers, and community at this incredible event - You will not want to miss our speakers!

"Never spread the lie in the headline" should be a hard rule of 21st century journalism. Research shows that repeating lies helps to spread them, and people read headlines more than they read stories.

Prostaglandins in tumor immune response are often overlooked (a ‘been there done that’ mentality) - but there remains tremendous therapeutic opportunity in understanding this fundamental pathway.

Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia. www.newyorker.com/culture/the-...

Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance. Here’s what to know about the new coalition.

#Review🚨 Spicer & team highlight our recent understanding of neutrophil extracellular traps #NETs biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies. 📖 👇

A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪

..cross your 't's folks.. here's how! www.nature.com/articles/s41...

ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...

Great. "Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics." www.ft.com/content/23e9...

Way to call out these thieves, perfect line.

My overview of MSI-H colorectal cancer management post ASCO and ESMO, aka “the ATOMIC diss track,” is up on VuMedi: www.vumedi.com/video/manage...

Next week LinkedIn will use your personal data for AI training by automatically enabling permissions. To manually turn off go to: Settings ➡️ Data Privacy ➡️ under “How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off

Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home

Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too

Finally read the paper and it's worth the buzz. mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time. www.nature.com/articles/s41...

YAP is a tough drug target with implications in resistance to immunotherapy and other treatments, these are some very encouraging results www.nature.com/articles/s41...

The tumor immunology and immunotherapy lecture "Know the System Know the Drug,” that Dan Schrum and I recorded for trainees, is up on YouTube! If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk. m.youtube.com/watch?v=atiS...

No words

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression https://www.medrxiv.org/content/10.1101/2025.10.06.25337175v1

Lactate impairs TLS formation - nice pre print www.biorxiv.org/content/10.1...

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

“Chris wasn’t even 10 and government funding was already working toward his cure. So, what are we risking in 30 years by cutting NIH funding? …that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”

One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹

It’s the difference between life & death. The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy. They are lying to you. With fatal consequences. While making money. 3/

One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹