🗨️ “Vaccines have done more to improve public health than any other medical intervention.” A Viewpoint focuses on cancer vaccines and the future of immunotherapy: spkl.io/63322AYP7k

For every trainee who succeeds at getting some super difficult experiment to yield interesting results, there are another dozen who fruitlessly spun their wheels for years. My advice: explore many technically feasible experiments and follow up on interesting leads

High fat diets “ready the soil” for cancer to grow in the liver. This has been inferred to many degrees for years but its good to see some mechanism: www.cell.com/cell/fulltex...

Americans & Europeans needlessly exposing African babies to preventable diseases just to see if they can find something that would justify their preexisting antivaccine beliefs is not only unscientific and actually anti-science, it is very much reminiscent of colonialist, racist human rights abuses

At the colorectal cancer alliance summit, where the goal is very, very clear:

Important PSA:

Prasad, Makary and others who claim that COVID19 vaccines killed 10 children are not telling the truth. According to @jeremyfaust.bsky.social, the committee that worked on this question reported that there were ZERO deaths that they were certain were caused by the vaccines. Well worth reading.

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

The biggest clue to cranks that there is no vaccine conspiracy is that Doctors and Scientists continue to vaccinate their own children at record rates.

Save the date: Saturday, March 14th, 2026 join us for the CRUSH Colorectal Cancer 5K at The River Church in Durham. Support our patients, advocates/caregivers, researchers, and community at this incredible event - You will not want to miss our speakers!

"Never spread the lie in the headline" should be a hard rule of 21st century journalism. Research shows that repeating lies helps to spread them, and people read headlines more than they read stories.

Prostaglandins in tumor immune response are often overlooked (a ‘been there done that’ mentality) - but there remains tremendous therapeutic opportunity in understanding this fundamental pathway.

Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia. www.newyorker.com/culture/the-...

Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance. Here’s what to know about the new coalition.

#Review🚨 Spicer & team highlight our recent understanding of neutrophil extracellular traps #NETs biology in cancer and emphasize both the translational data available and the need for further clinical trials evaluating NETs and NET-directed therapies. 📖 👇

A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪

..cross your 't's folks.. here's how! www.nature.com/articles/s41...

ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...

Great. "Since the full scope of Nazi crimes was revealed, eugenics has fallen deeply out of fashion. Yet if the term has become taboo, some of the practices associated with it have not. Today we are witnessing the emergence of what could be called libertarian eugenics." www.ft.com/content/23e9...

Way to call out these thieves, perfect line.

My overview of MSI-H colorectal cancer management post ASCO and ESMO, aka “the ATOMIC diss track,” is up on VuMedi: www.vumedi.com/video/manage...

Next week LinkedIn will use your personal data for AI training by automatically enabling permissions. To manually turn off go to: Settings ➡️ Data Privacy ➡️ under “How LinkedIn uses your data” click “Data for Generative AI improvement” ➡️ toggle off

Join us as we take a step back in time and celebrate all we have accomplished in immuno-oncology over the past 40 years! We will be remembering all our IO milestones as we lead up to our 40th Anniversary Annual Meeting! sitcancer.org/2025/home

Extremely useful for spectral flow cytometry enthusiasts- thanks @labliston.bsky.social I will share with our core too

Finally read the paper and it's worth the buzz. mRNA vaccines saved 20 million lives in a global pandemic and the technology is opening up new avenues for the treatment of deadly cancers. This is really one of the most impactful scientific developments of our time. www.nature.com/articles/s41...

YAP is a tough drug target with implications in resistance to immunotherapy and other treatments, these are some very encouraging results www.nature.com/articles/s41...

The tumor immunology and immunotherapy lecture "Know the System Know the Drug,” that Dan Schrum and I recorded for trainees, is up on YouTube! If you are interested in tumor immune evasion and immunotherapeutic mechanisms of action, check out our talk. m.youtube.com/watch?v=atiS...

No words

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression https://www.medrxiv.org/content/10.1101/2025.10.06.25337175v1

Lactate impairs TLS formation - nice pre print www.biorxiv.org/content/10.1...

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

“Chris wasn’t even 10 and government funding was already working toward his cure. So, what are we risking in 30 years by cutting NIH funding? …that progress gave us the tools we needed to treat Chris the right way, up front, with the standard of care, since the science and trials had been done.”

One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹

It’s the difference between life & death. The wellness industry profits by creating distrust of medicine, falsely claiming “real” cancer cures are being hidden so doctors can keep patients sick & poison them with chemotherapy. They are lying to you. With fatal consequences. While making money. 3/

One of my amazing patients who is in remission from MSI-H colorectal cancer after immunotherapy is featured!! I am so proud 🥹

Former NCI official’s nonprofit seeks to tell the stories of cancer patients Patient Action for Cancer Research aims to show impact of federal research https://cancerletter.com/the-cancer-letter/20251003_1/

Early-onset gastrointestinal cancer is currently the most rapidly increasing early-onset cancer in the US. This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures. ja.ma/46BERoo

The Damage Done: @marianneguenot.bsky.social tells the story of clinical trials derailed by the administration's reckless science policy, across kidney disease, HIV, Alzheimer's disease, and cancer. Years of work and money thrown away, at times just short of a cure. www.nature.com/articles/s41...

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Screens not genes Such a good ad for colorectal cancer screening! www.usatoday.com/story/entert...

ICYMI: New online! Food as medicine in gastrointestinal cancer therapy

Early-onset colorectal cancer is expected to become the leading cause of #cancer death in ages 20 to 49 in the U.S. by 2030. Research is urgently needed to better detect and treat patients, argues this #SciencePerspective: https://scim.ag/3IfUgBA #WorldCancerResearchDay

We're thrilled to be here on BlueSky to bring you the latest practice-changing oncology research from all six JCO Journals! Follow-us for great content from #JCO, #JCOOP, #JCOGO, #JCOPO, #JCOCCI, & #JCOOA.

🧪🧪 Just a reminder, a 2024 study published in JAMA that included over 2 million children found that using acetaminophen, the active ingredient in Tylenol, during pregnancy was not associated with increased risk of autism, ADHD, or intellectual disability in children. jamanetwork.com/journals/jam...

Reading papers is a basic skill (and dare I say duty?) of scientists, and I include medical doctors in that group. Keeping abreast of the literature is a foundational part of our professions. There aren’t good shortcuts. In any case, reading papers regularly is fun. arstechnica.com/ai/2025/09/s...

Online now: A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer

Seriously one of my favorite characters in any show ever

Thanks Medscape for the opportunity to further the conversation on young onset gastrointestinal cancers by exploring possible causes, barriers to screening, and symptoms of concern. www.medscape.com/viewarticle/...