Happy to see this amazing work finally out. We used our NePSTA model to acurately predict the epigenetic subtypes of meningiomas based on cell-type abundance in subgraphs containing gene expression features + spatial adjacency.

Can immunotherapy ever work in #glioblastoma? In a new #NatureCancer review, we share our perspective on current limitations and future directions: www.nature.com/articles/s43... #NORLUX, #LIH , @fnr.lu #TELEVIE, @glioresolve.bsky.social, @michael-platten.bsky.social

Happy to share a new #NORLUX study on how humanized patient-derived xenografts of #glioblastoma can be useful in investigating immunosuppression and clinically-relevant immunotherapy testing. See for more: www.biorxiv.org/content/10.1... #immunotherapy, #preclinicalmodeling,

Amazing Keynote talk by @heilandhenrik.bsky.social on "Translational Data Integration and Technological Developments in Neuro-Oncology" at the ongoing #SNO2025 in Hawaii.🧠

Be sure to check the @milolab.bsky.social talks including our work on "Deciphering spatiotemporal trajectories of tissue adaptation after surgical resection of glioblastoma."

#EANO2025 was awesome. Great time interacting with mentors and colleagues. Looking forward to another exciting meeting.

Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!

📢 @eanoassociation.bsky.social 2025 kicks off today in Prague! Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning. More info 👉 www.eortc.org/blog/2025/10... #EANO2025 #NeuroOncology @qol.eortc.org

Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1... @fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors

NEW content online!

Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...

#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...

Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉

Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b

The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group. Great people, great science. #glioblastoma #spatialtranscriptomics #scRNA-seq

📣 Open computational PhD & Postdoc positions! Excited about the open positions as part of our newly funded Emmy Noether Group are online now under kocakavuklab.vercel.app/joinus 📢 Please RT (what's the bsky equivalent here?) and distribute ! 👇A quick instruction on how to apply

Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas https://go.nature.com/434f4ns

🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙

Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social

Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors. @10xGenomics 🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs t.co/GmA9MLNKy1

Ever wondered what makes brain tumors tick? Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content! www.instagram.com/the_milolab/...

Happy to share your latest collaboration with @sahm_lab leveraging spatial transcriptomics @10xGenomics for neuropathology diagnosis #DeepLearning ! 107 patients across 15 CNS tumors! www.nature.com/articles/s43...

Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab. Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.

New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social www.nature.com/articles/s43...

new out in Nature: lovely paper www.nature.com/articles/s41...

Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...

Awesome work.👌

🧵Just in time for : New research from the Venkataramani lab @CellCellPress maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social 1/15

It's a wrap #SNO2024! It was a great opportunity to present our work, listen to amazing and inspiring talks, and have fruitful discussions with friends and mentors. Looking forward to #SNO2025 in #Honolulu.

Truly inspiring talk by Crystal Mackall on their journey in treating brain tumors with #CARTcells. #SNO2024

Amazing talk by Henrik Heiland on using #spatialtranscriptomics data to model glioblastoma evolution #SNO2024