My awesome grad student Shashank and I wrote this paper trying to look at broader patterns of HT in TEs. HT is happening everywhere! DNA transposons jump further than other classes! www.biorxiv.org/content/10.1...

Happy Halloween 🎃👻💀 from the crypt-keeper wasp, who lays its eggs into a crypt created by its host, then manipulates the host’s behavior for its own benefit, before devouring it from the inside out and emerging through its face! en.wikipedia.org/wiki/Euderus...

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Behold, my new favorite type of plot: roadkill

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

if you see this post, your actions are: - if you have a spare buck, give it to Wikipedia, then repost this - if you don't have a spare buck, just repost your action is mandatory for the world's best source of information to survive

Please share/repost widely: I have a postdoc position available. Please see ad below and reach out to apply. academicpositions.harvard.edu/postings/15449

Not today, parasitic #wasps!✋🚫 #Stinkbugs use a fungus-carrying organ on their hind legs to coat their eggs in #fungi🍄🦵 This provides a physical defense against #parasitic wasp oviposition🛡️ www.science.org/doi/10.1126/...

A lot of pressure on the different grant schemes, and pretty much independent of career stage.

Many questions remain about how these patterns emerge and how the right piRNA precursors are selected, but that's a story for another day ;-). For now, check out the story and explore the genome yourself. We'd love to get your feedback! (11/12) www.biorxiv.org/content/10.1...

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

PREACH! www.nature.com/articles/s41...

I maintain that the most important is the coffee machine

My HPLC was definitely overlooked www.nature.com/articles/d41...

I've heard some bizarre takes, but this one takes the prize (apparently, together with the word processor that was used to write it) www.nature.com/articles/d41...

🚀 New on the Bioconductor Blog: GPU Support in Bioconductor Bioconductor is building better support for GPU-accelerated package development for faster and more scalable analysis workflows Learn how package maintainers can leverage this new GPU infrastructure: blog.bioconductor.org/posts/2025-1...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

Nowadays, too many institutions thinking ‘if we build it they will come’ combined with a shortsighted research funding model, a saturated Phd training sector, bloated admin load, and a general decline in creativity. Tough times indeed!

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization. www.science.org/doi/10.1126/...

Yes, yes, Europe has its benefits. Walkable cities. Cultural heritage. Amazing food. Little gun violence. Healthcare. Governments that are not shut down. But the number of website pop-ups asking one to accept cookies renders the continent pretty much unlivable.

It feels great to close 3 powerpoints, 10 word documents and 57 browser tabs after submitting the grant😌

👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻 Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms. 🚨 Deadline Oct 1st!! 🚨 Please re-post and help us spread the word far and wide! ✈ ki.varbi.com/en/what:job/...

A single brain infusion of miRNA targeting CAG repeats slows the progression of Huntington's disease by 75% in patients. This is something that I never thought I would see in my lifetime. www.uniqure.com/investors-me...

Kicked off a series on #Drosophila TE discovery and naming. The first post covers elements that predate the term "mobile element", and more. artemilin.dev/posts/te_nam...

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky

🧀🧀🧀‼️

The papers that I enjoyed reading this week, especially the second one: artemilin.dev/posts/202509...

This gorgeous fella landed on my knee last week when I was in Vienna, chilled for a bit, didn't mind me touching him at all and then disappeared. Can anyone help identify? I would say that his length wasn't exceeding 6-7 mm. #entomology

Living organisms are assumed to produce same-species offspring. A study in Nature reports a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species. go.nature.com/3V68MP0 🧪

Together with @soreklab.bsky.social, our labs discovered that the human cGAS-STING pathway evolved from ancient bacterial proteins in CBASS anti-phage defense www.nature.com/articles/s41... www.nature.com/articles/s41... www.nature.com/articles/s41...

Hoher Dachstein, 2997 m, no sherpas, no oxygen. (Don't mind the cable car)

In all my obsession with RNA silencing, I realized I became blind to the significance of autoregulation of DNA transposons. Which is funny, because it was characterized in many ways by my Ph.D. advisor. From 2013: elifesciences.org/articles/00668

Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.

DNMT3Beauty

#TEsky #RNAsky #RNAbiology

Climate models since the 1970s nailed it—most predicted global warming almost exactly as it happened.

I don't know the exact number of Nobel Prize laureates who wrote cooking books, but here's a rösti recipe from Christiane Nüsslein-Volhard: artemilin.neocities.org/post/250817_nv

We are hiring a lab technician! Join our group studying signaling networks in #Drosophila, with a possibility to carry out a research project. Please RT. Job posting: employmentopportunities.umb.edu/boston/en-us... Veraksa lab website: www.faculty.umb.edu/alexey_verak...

I'm starting to think that conda isn't the best option for isolated environments. I have just 7 envs, some of which run a couple of dedicated tools and the number of files required to run them is gigantic. Mind you, today, the large file number exerts much harder strain on storage than the file size

🔬 From our August issue (rupress.org/jcb/issue/22...): A confocal image of a #Drosophila egg chamber where #actin filaments are labelled with rhodamine phalloidin and color-coded to represent different depths within nurse cells. From Ghosh et al.: rupress.org/jcb/article/...

Did you know #fruitflies ovulate roughly 70 times a day? This makes #Drosophila a powerful model for studying the #genetics behind #ovulation in humans. Here's a stunning look at fly ovaries under a #fluorescent microscope. Each blue dot is a cell nucleus. The beauty of #DrosophilaOogenesis!

It's so much easier to destroy than to build, and the U.S. admin once again proves it has firmly stepped onto the path of total scientific destruction

Casual reminder that you can use spring to compress your raw basecalled sequencing data even more than by using gzip or bz2. Save some space for bams!

piRNAs are essential for transposon silencing in the animal germline. But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response? Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @plosbiology.org 🧪 plos.io/44Mq3RI

Colossal BS is getting even shadier