This seems more like a hard sell than a soft cell.

I find it a bit concerning that the authors went to journalists after the rejection, even before the preprint was posted. Also, synthetic biology does not strike me as a field of “underdog scientists”; if anything, it seems like exactly the kind of field where results can easily be overhyped.

You vs the guy she told you not to worry about

Major development in the #Transposon world! Repbase is joining the Dfam project and becomes open-access! link.springer.com/article/10.1...

This sencha is lit🌞

Now online! Gregory J. Hannon (1964–2026)

How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0

@ericanadolski.bsky.social et al. present sex-specific chromosomal-level genome assemblies of the southern African beetle Onthophagus binodis; analyses show that the nine autosomes and the X chromosome are likely conserved throughout Onthophagini. 🔗 doi.org/10.1093/gbe/evag023 #genome #evolution

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Have you ever wondered how chromatin states shape developmental trajectories? In our preprint, we address this question using single-cell nanoCUT&Tag, a method developed by Marek Bartosovic @mardzix.bsky.social, which simultaneously profiles active H3K27ac and repressive H3K27me3 in the same nucleus

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog: "In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes." More: cen.acs.org/research-int...

Next year it's gonna be a giant sequoia (from the same acorn)

Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!

My 1999 self would weep at how totally broken the internet has become. AI slop, social media walled gardens that rot the brain, surveillance pricing and advertising, every single goddamn website has an endless cloudflare captcha loop before you get to read anything. Burn it all down.

🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social www.biorxiv.org/content/10.6... Curious? Here’s a breakdown:

#Paper Our new study on #Asgard archaea is out in Nature Communications. We find a distinctive evolutionary pattern: widespread #HGT, but genome expansion mainly through gene duplication. An interesting window into the origins of #eukaryotic complexity. www.nature.com/articles/s41...

I’m re-reading Eugene Koonin’s The Logic of Chance, and it might be one of the most important books I’ve ever read. I hadn’t fully realized it before, but for me it feels like a necessary companion to The Selfish Gene - my favorite biology book.

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

obsessed with this US department of agriculture zine about snail farming from 1986 openknowledge.fao.org/server/api/c...

I am disgusted that Danske Bank has decided to terminate the account of Stoparmy, a Russian non-profit working to help end military conscription.

I'm super happy to finally see the paper published ! Check out the full story here: link.springer.com/article/10.1...

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. www.biorxiv.org/content/10.6...

of many projects Craig Venter led, of personal significance was the fly genome, a unique and i think unexpected collaboration of his company Celera Genomics and the BDGP, led by my pd advisor Gerry Rubin. the power of a shotgun sequenced metazoan, benchmarked to a physical map, transformed genomics.

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

30 years ago, the yeast genome was completed by an international team of scientists. Since then, S.cerevisiae has become a key model for understanding conserved biological processes and driving discoveries. Explore the annotated Baker’s yeast R64-1-1 genome in @ensembl.org @yeastgenome.bsky.social

All dogma dispute aside, this is the first time I hear about an enzyme that builds a dna sequence (AC repeats) without a nucleic acid template. Fantastic work!

Very intense queen bumblebee migration at Rosenvold, Vejle Fjord, Denmark today. The bees migrated into the wind towards SW along the coastline, many crossing the fjord. Intensity across a 100 meter front estimated to 5-10 individuals per second. @thijsfijen.bsky.social

I had an amazing time at #DrosEU2026 in beautiful Montpelier 🇫🇷 this week! Met wonderful people, shared exciting ideas, saw brilliant research from all the participants🔥 Huge thanks to the organizers!

Very upsetting to hear the sad news of Greg Hannon’s passing. I always enjoyed our far too few conversations we had over the years. He had an interesting and insightful perspective on any science being discussed. He will be missed. www.cruk.cam.ac.uk/news/in-memo...

PostDoc position available! (links in post below) Feel free to share!

In Drosophila, a heterochromatin protein (HP2) must transcribe AAGAG satellite DNA before sperm packaging. Without it, Y-bearing spermatids die more than X-bearing ones, producing sex-ratio meiotic drive. https://www.biorxiv.org/content/10.1101/2025.01.10.632443

Male octopuses use a specialized arm that acts as both a sensory and reproductive organ to navigate the female’s mantle, locate oviducts, and transfer sperm. These findings reveal how sensory systems shape reproductive behavior and drive speciation. Learn more in Science: https://scim.ag/4dYMtFq

The variety of German bees before the Industrial Revolution (187, top) vs after the introduction of pesticides (43, bottom), DHM

📣📣📣 A post-doc opportunity not to be missed in an ATIP-Avenir funded lab in the @i2bcparissaclay.bsky.social (and our neighbor 🪰🔬🧬)! Heterochromatin, spermatogenesis, meiotic drive and Drosophila, with @cecilecourret.bsky.social. Apply before the position fills!

Joseph Gordon-Levitt as the first author, Zooey Deschanel as the editor, meet the (500) days of suffer🥀

If you love working with Drosophila and you’re looking for a PhD in a great, supportive environment with an exciting project, this is your chance💫

🚀🚀🚀

Time to share some data that might get buried in the supplement of our recent paper here rdcu.be/e91Kj Here you can see how cells intercalate in a coordinated fashion. They move from a double rowed organisation to a single row stalk. 🧵

Batch-22

Join us in Heidelberg for your PhD! If you are excited about CRISPR genome engineering and would like to develop and apply new methods to investigate Wnt signaling in different model systems, than this project is for you. More info here: my-hbigs.uni-heidelberg.de/site/index.p... 🧪🧬🔬

Surprisingly, a very good analogy😁

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

Excited to share my PhD work! The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development. Here’s a quick Blue-torial 🙂 (1/n) www.nature.com/articles/s41...

🔬 Recruiting a Postdoc!!!! I’m looking for a motivated postdoc to join my lab and work on characterizing the role of a heterochromatin protein involved in a sex-ratio meiotic drive system in Drosophila. If you know someone who might be interested, please share widely!

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...

Can't wait to release a 10-year-old birthday version for SeqKit! - 10 years - 2 papers, 3500 citations - 20 contributors - 40 subcommands - 880 commits - 500 issues - 685.5K Bioconda total downloads Thank you all, dear contributors and users! I'll keep maintaining it. github.com/shenwei356/s...

"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa" Nobody can predict what can happen with your work. www.sciencedirect.com/science/arti...